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UHRF2 encodes a nuclear protein which is involved in cell-cycle regulation. Zusätzlich bieten wir Ihnen Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal UHRF2 Primary Antibody für IHC, WB - ABIN2776012
Liu, Zhu, Zhou, Zhang, Xu, Li: [Analysis of diagnosis and misdiagnosis of pulmonary thromboembolism in emergency]. in Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 2004
Show all 2 Pubmed References
UHRF2 expression is reduced in some leukemia cell lines, this correlates with promoter hypermethylation, and similar UHRF2 methylation profiles are seen in primary human leukemia samples. Thus, UHRF2 and 5hmC are widely present in differentiated human tissues, and UHRF2 protein is poorly expressed or mislocalized in diverse human cancers.
Here, we report the complex structure of PCNA (zeige PCNA Antikörper) and the peptide ((784)NEILQTLLDLFFPGYSK(800)) derived from UHRF2 that contains a PIP (zeige PIP Antikörper) box. Structural analysis combined with mutagenesis experiments provide the molecular basis for the recognition of UHRF2 by PCNA (zeige PCNA Antikörper) via PIP (zeige PIP Antikörper)-box.
Results show that UHRF2 down-regulates a number of epithelial-mesenchymal transition markers and up-regulates the expression of transcription factors. The study also suggests that UHRF2 play a role in tumor metastasis.
TIP60 (zeige KAT5 Antikörper) acted downstream of UHRF2 to regulate H3K9ac and H3K14ac expression.
The overexpression of UHRF2 increased the expression of H3K9ac in L02 normal cells (P<0.01), but decreased the expression of histone H3 (zeige HIST3H3 Antikörper) lysine 9 acetylation in HepG2 cancer cells.
study suggests that ZNF618 (zeige ZNF618 Antikörper) is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo.
UHRF2 may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator after curative operation
A hydrogen bond between the hydroxyl group of 5hmC and UHRF2-SRA (zeige SRA1 Antikörper) is critical for their preferential binding.
UHRF2 is a transcriptional target of E2F (zeige E2F1 Antikörper), that it directly interacts with E2F1 (zeige E2F1 Antikörper).
UHRF2, the homolog of UHRF1 (zeige UHRF1 Antikörper), interacts with N-methylpurine DNA glycosylase (MPG (zeige MPG Antikörper)) in cancer cells.
5mC levels are decreased at certain genomic loci in the brains of Uhrf2 knockout mice. UHRF KO mice develop frequent spontaneous seizures.
Uhrf2 null mice exhibit a reduction of 5-Hydroxymethylcytosine in the brain, including the cortex and hippocampus. Furthermore, the Uhrf2 null mice exhibit a partial impairment in spatial memory acquisition and retention.
Uhrf2 is highly expressed in aorta and aortic vascular smooth muscle cells.
UHRF2 is not able to rescue the DNA methylation (zeige HELLS Antikörper) defect in Uhrf1 (zeige UHRF1 Antikörper) null mouse embryonic stem cells.
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
E3 ubiquitin-protein ligase UHRF2
, Np95-like ring finger protein
, RING finger protein 107
, np95/ICBP90-like RING finger protein
, nuclear protein 97
, nuclear zinc finger protein NP97
, ubiquitin-like PHD and RING finger domain-containing protein 2
, ubiquitin-like, containing PHD and RING finger domains, 2
, ubiquitin-like-containing PHD and RING finger domains protein 2
, nuclear zinc finger protein Np97
, ubiquitin-like, containing PHD and RING finger domains 2