anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) Antikörper

UHRF2 encodes a nuclear protein which is involved in cell-cycle regulation. Zusätzlich bieten wir Ihnen Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Gen	GeneID	UniProt
UHRF2	115426	Q96PU4
UHRF2	109113	Q7TMI3
UHRF2	309331

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Top anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Antikörper auf antikoerper-online.de

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Katalog Nr.	Reaktivität	Wirt	Konjugat	Applikation	Menge	Anbieter	Lieferzeit	Preis	Details
ABIN2776012	Rind (Kuh)	Kaninchen	Unkonjugiert	IHC, WB	100 μL	Anmelden zum Anzeigen	2 bis 3 Tage	$319.00	Details
ABIN2775913	Rind (Kuh)	Kaninchen	Unkonjugiert	WB	100 μL	Anmelden zum Anzeigen	2 bis 3 Tage	$289.00	Details
ABIN3044559	Human	Kaninchen	Unkonjugiert	IHC (p), WB	100 μg	Anmelden zum Anzeigen	4 bis 6 Tage	$280.00	Details
ABIN393647	Human	Maus	Unkonjugiert	IF, WB	100 μg	Anmelden zum Anzeigen	8 bis 11 Tage	$527.50	Details
ABIN2776011	Rind (Kuh)	Kaninchen	Unkonjugiert	WB	100 μL	Anmelden zum Anzeigen	2 bis 3 Tage	$289.00	Details
ABIN1525700	Human	Kaninchen	Unkonjugiert	IF, IHC, WB	100 μg	Anmelden zum Anzeigen	2 bis 3 Tage	$335.00	Details
ABIN1875279	Human	Kaninchen	Unkonjugiert	IF, IHC, WB	100 μL	Anmelden zum Anzeigen	16 Days	$366.77	Details
ABIN216288	Rind (Kuh)	Kaninchen	Unkonjugiert	IHC, IHC (p), WB	50 μg	Anmelden zum Anzeigen	11 bis 14 Tage	$551.83	Details
ABIN468027	Fledermaus	Kaninchen	Unkonjugiert	WB	50 μg	Anmelden zum Anzeigen	11 bis 14 Tage	$551.83	Details
ABIN6265881	Human	Kaninchen	Unkonjugiert	ELISA, ICC, IF, IHC, WB	100 μL	Anmelden zum Anzeigen	11 bis 12 Tage	$390.77	Details

Weitere Produktkategorien zu Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Antikörper

Am meisten referenzierte anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Antikörper

Cow (Bovine) Polyclonal UHRF2 Primary Antibody für IHC, WB - ABIN2776012 : Liu, Zhu, Zhou, Zhang, Xu, Li: [Analysis of diagnosis and misdiagnosis of pulmonary thromboembolism in emergency]. in Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 2004 (PubMed)
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Weitere Antikörper gegen Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Interaktionspartner

Human Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) Interaktionspartner

UHRF2 may be a negative regulator of EMT and a novel prognostic biomarker for ESCC.
UHRF2 expression is reduced in some leukemia cell lines, this correlates with promoter hypermethylation, and similar UHRF2 methylation profiles are seen in primary human leukemia samples. Thus, UHRF2 and 5hmC are widely present in differentiated human tissues, and UHRF2 protein is poorly expressed or mislocalized in diverse human cancers.
Here, we report the complex structure of PCNA and the peptide ((784)NEILQTLLDLFFPGYSK(800)) derived from UHRF2 that contains a PIP box. Structural analysis combined with mutagenesis experiments provide the molecular basis for the recognition of UHRF2 by PCNA via PIP-box.
Results show that UHRF2 down-regulates a number of epithelial-mesenchymal transition markers and up-regulates the expression of transcription factors. The study also suggests that UHRF2 play a role in tumor metastasis.
TIP60 acted downstream of UHRF2 to regulate H3K9ac and H3K14ac expression.
The overexpression of UHRF2 increased the expression of H3K9ac in L02 normal cells (P<0.01), but decreased the expression of histone H3 lysine 9 acetylation in HepG2 cancer cells.
study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo.
UHRF2 may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator after curative operation
A hydrogen bond between the hydroxyl group of 5hmC and UHRF2-SRA is critical for their preferential binding.
UHRF2 is a transcriptional target of E2F, that it directly interacts with E2F1.
UHRF2, the homolog of UHRF1, interacts with N-methylpurine DNA glycosylase (MPG) in cancer cells.
Low UHRF2 mRNA expression is associated with malignant glioma.
UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131
NIRF may contribute to the coupling between the cell cycle network and the epigenetic landscape
In the present study, ubiquitin ligase, NIRF, binds to hepatitis B virus core protein and leads to the proteasome-mediated degradation of hepatitis B virus core protein in vivo.
NIRF is immediately adjacent to the single nucleotide polymorphism rs719725, which is reportedly associated with the risk of colorectal cancer.
NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA.
the cooperative interplay of Uhrf2 domains may contribute to a tighter epigenetic control of gene expression in differentiated cells
NIRF is involved in cell-cycle regulation
NIRF has ubiquitination activity, the hallmark of a ubiquitin ligase. PCNP was readily ubiquitinated in 293 and COS-7 cells, and NIRF ubiquitinated PCNP in vitro as well as in vivo.

Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) Antigen-Profil

Protein Überblick

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

Genbezeichner und Symbole assoziert mit UHRF2

ubiquitin like with PHD and ring finger domains 2 (UHRF2) Antikörper
ubiquitin-like, containing PHD and RING finger domains 2 (Uhrf2) Antikörper
ubiquitin like with PHD and ring finger domains 2 (Uhrf2) Antikörper

2310065A22Rik Antikörper
AI426270 Antikörper
AW214556 Antikörper
D130071B19Rik Antikörper
Nirf Antikörper
RNF107 Antikörper
URF2 Antikörper

Bezeichner auf Proteinebene für UHRF2

E3 ubiquitin-protein ligase UHRF2 , Np95-like ring finger protein , RING finger protein 107 , np95/ICBP90-like RING finger protein , nuclear protein 97 , nuclear zinc finger protein NP97 , ubiquitin-like PHD and RING finger domain-containing protein 2 , ubiquitin-like, containing PHD and RING finger domains, 2 , ubiquitin-like-containing PHD and RING finger domains protein 2 , nuclear zinc finger protein Np97 , ubiquitin-like, containing PHD and RING finger domains 2

GENE ID	SPEZIES
115426	Homo sapiens
474702	Canis lupus familiaris
613759	Bos taurus
109113	Mus musculus
309331	Rattus norvegicus
100715709	Cavia porcellus

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Show all anti-Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) Antikörper with Pubmed References

Human Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) Interaktionspartner

Protein Überblick

Genbezeichner und Symbole assoziert mit UHRF2

Bezeichner auf Proteinebene für UHRF2