USP8 Proteine
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation.
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Ubiquitin Specific Peptidase 8 (USP8) (AA 1-1118) protein (His tag) Protein
Ubiquitin Specific Peptidase 8 (USP8) (AA 777-1118) protein (T7 tag,His tag) Protein
Ubiquitin Specific Peptidase 8 (USP8) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag) Protein
Ubiquitin Specific Peptidase 8 (USP8) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag) Protein
Ubiquitin Specific Peptidase 8 (USP8) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag) Protein
USP8 Protein Überblick
Protein Überblick
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.
Genbezeichner und Symbole assoziert mit USP8
- ubiquitin carboxyl-terminal hydrolase 8 (LOC9310109) Antikörper
- ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369) Antikörper
- ubiquitin specific peptidase 8 (USP8) Antikörper
- ubiquitin specific peptidase 8 (Usp8) Antikörper
- AI574262 Antikörper
- AW557536 Antikörper
- HumORF8 Antikörper
- mKIAA0055 Antikörper
- Ubpy Antikörper
Bezeichner auf Proteinebene für USP8
ubiquitin carboxyl-terminal hydrolase 8 , ubiquitin-specific-processing protease 8 , ubiquitin specific peptidase 8 , ubiquitin carboxyl-terminal hydrolase 8-like , deubiquitinating enzyme 8 , hUBPy , ubiquitin isopeptidase Y , ubiquitin specific protease 8 , ubiquitin thioesterase 8 , ubiquitin thiolesterase 8 , putative deubiquitinating enzyme
GENE ID | SPEZIES |
---|---|
9310109 | Arabidopsis lyrata subsp. lyrata |
10031598 | Arthroderma gypseum CBS 118893 |
100408559 | Callithrix jacchus |
100437819 | Pongo abelii |
9101 | Homo sapiens |
296121 | Rattus norvegicus |
84092 | Mus musculus |
100157546 | Sus scrofa |
415451 | Gallus gallus |
100351436 | Oryctolagus cuniculus |
100720255 | Cavia porcellus |
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