Ubiquitin Specific Peptidase 8 Proteine (USP8)

Human Ubiquitin Specific Peptidase 8 (USP8) Interaktionspartner

1. Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A, NRDP1 (zeige RNF41 Proteine), and USP8 form tripartite complex; CLEC16A-NRDP1 (zeige RNF41 Proteine)-USP8 complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A = C-type lectin domain family 16 member A; NRDP1 (zeige RNF41 Proteine) = ubiquitin-protein ligase (zeige UBE2K Proteine) NRDP1 (zeige RNF41 Proteine); USP8 = ubiquitin specific peptidase 8)

2. the EGFR (zeige EGFR Proteine)-USP8-trichoplein-Aurora A (zeige AURKA Proteine) axis is a critical signaling cascade that restricts ciliogenesis in dividing cells, and functions to facilitate cell proliferation

3. in human cells, Usp8 knockdown increased the lysosomal degradation of alpha-synuclein.

4. Overexpression of USP8 in lung adenocarcinoma is an early event during the course of tumor progression, and is related to EGFR (zeige EGFR Proteine) expression.

5. Somatic mutations in USP8 are common in Nelson's tumors, and are associated with less favorable outcome after surgery.

6. Data indicate that USP8 functions as a novel deubiquitylase of FLIPL and inhibits extrinsic apoptosis by stabilizing FLIPL.

7. Somatic USP8 gene mutations are a common cause of pediatric Cushing disease due to pituitary adenoma.

8. findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 (zeige BACE Proteine) by deubiquitinating lysine 501.

9. USP8 regulates VEGFR2 (zeige KDR Proteine) trafficking, signaling and proteolysis.

10. Ubpy loss of function results in the accumulation of autophagosomes due to a blockade of the autophagy flux.

Mouse (Murine) Ubiquitin Specific Peptidase 8 (USP8) Interaktionspartner

1. the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome.

2. in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions.

3. The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.

4. a role for the USP8.STAM (zeige STAM Proteine) complex as a protective mechanism regulating early endosomal sorting of EGFR (zeige EGFR Proteine) between pathways destined for lysosomal degradation and recycling.

5. USP8 was able to interact with spermatid endosomal-sorting complex required for transport-0 and microtubule structures; USP8 can directly link, via its MIT domain, the labeled vesicles/developing acrosome to microtubules.

6. in wobbler testis expression of mouse ubiquitin-specific processing protease (mUBPy)is up-regulated, while a differential sorting of the protein characterizes wobbler spermatids where acrosome formation is impaired

7. Data indicate a novel mechanism where diacylglycerol kinase delta (zeige DGKD Proteine) and protein kinase (zeige CDK7 Proteine) Calpha (zeige PRKACA Proteine) modulate the levels of ubiquitinated epidermal growth factor (zeige EGF Proteine) receptors through Akt (zeige AKT1 Proteine) and ubiquitin-specific protease 8.

8. deubiquitinating enzyme specifically expressed in testis, associates with the acrosome and centrosome in mouse germ cells

9. Results indicate that Nrdp1 (zeige RNF41 Proteine) is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 (zeige RNF41 Proteine) activity by mediating its stabilization.

10. We conclude that UBPY negatively regulates the rate of EGFR (zeige EGFR Proteine) down-regulation by deubiquitinating EGFR (zeige EGFR Proteine) on endosomes.