USP8 Produkte
(Ubiquitin Specific Peptidase 8 (USP8))
Kategorien
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.
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Ausgewählte USP8 Kategorien
USP8 Antikörper
High quality antibodies with extensive validation data.
USP8 ELISA Kits
Reliable ELISA kits for a wide range of species.
USP8 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene USP8 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IHC (p), IP, ICC
Validierungen
- (4)
Kat. Nr.
ABIN2855692
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA
Validierungen
- (2)
Kat. Nr.
ABIN7174360
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN388891
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene USP8 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6960352
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (2)
Kat. Nr.
ABIN1117711
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene USP8 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125599
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3096238
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7398275
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren USP8 Produkten
: "Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. ..." in: Nature communications, Vol. 7, pp. 11971, (2016) (PubMed).: "Mutations in the deubiquitinase gene USP8 cause Cushing's disease." in: Nature genetics, Vol. 47, Issue 1, pp. 31-8, (2014) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease." in: Oncogene, Vol. 20, Issue 29, pp. 3869-79, (2001) (PubMed).
Synonyme und alternative Namen zu USP8
ubiquitin carboxyl-terminal hydrolase 8 (LOC9310109), ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369), ubiquitin specific peptidase 8 (USP8), ubiquitin specific peptidase 8 (Usp8), AI574262, AW557536, HumORF8, mKIAA0055, UBPY, UbpyBezeichner auf Proteinebene für USP8
- ubiquitin carboxyl-terminal hydrolase 8
- ubiquitin-specific-processing protease 8
- ubiquitin specific peptidase 8
- ubiquitin carboxyl-terminal hydrolase 8-like
- deubiquitinating enzyme 8
- hUBPy
- ubiquitin isopeptidase Y
- ubiquitin specific protease 8
- ubiquitin thioesterase 8
- ubiquitin thiolesterase 8
- putative deubiquitinating enzyme
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