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TYRP1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Zusätzlich bieten wir Ihnen Tyrosinase-Related Protein 1 Proteine (12) und Tyrosinase-Related Protein 1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal Tyrosinase-Related Protein 1 Primary Antibody für ICC, IF - ABIN409307
Raphaël, Lehenkyi, Vandenberghe, Beck, Khalimonchyk, Vanden Abeele, Farsetti, Germain, Bokhobza, Mihalache, Gosset, Romanin, Clézardin, Skryma, Prevarskaya: TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival. in Proceedings of the National Academy of Sciences of the United States of America 2014
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Human Polyclonal Tyrosinase-Related Protein 1 Primary Antibody für IF (p), IHC (p) - ABIN1714403
Cui, Song, Geng, Ding, Qin, Fan, Dong, Geng: The expression of KRT2 and its effect on melanogenesis in alpaca skins. in Acta histochemica 2016
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Cow (Bovine) Polyclonal Tyrosinase-Related Protein 1 Primary Antibody für IHC, WB - ABIN2781815
Horibe, Satoh, Shiota, Kumagai, Horike, Takemori, Uesato, Sugie, Obata, Kawahara, Nagaoka: Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells. in Journal of natural medicines 2013
Human Polyclonal Tyrosinase-Related Protein 1 Primary Antibody für IHC, IHC (p) - ABIN4893177
Abad, Wieërs, Colau, Wildmann, Delair, Dhote, Brézin, Kawakami, Coulie, van der Bruggen: Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient. in Molecular vision 2014
Human Polyclonal Tyrosinase-Related Protein 1 Primary Antibody für IHC, IHC (fro) - ABIN4362885
Perrouin Verbe, Bruyere, Rozet, Vandier, Fromont: Expression of store-operated channel components in prostate cancer: the prognostic paradox. in Human pathology 2016
a mutation in tyrp1A, one of the two tyrp1 paralogs in zebrafish, causes melanophore death leading to a semi-dominant phenotype
The Fugu tyrp1 promoter can direct transgene expression in a cell-type-specific manner in zebrafish. Our findings provide evidence supporting differential regulations of melanin-synthesizing genes in RPE (zeige RPE Antikörper) cells and the NCDM in zebrafish.
we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1) and Tyrosinase (TYR (zeige TYR Antikörper)), as well as genes with unknown functions.
A mutation in exon 2 of the TYRP1 gene leads to a premature stop codon at position 190 of the deduced amino acid sequence. Genotyping 203 rabbits of 32 different breeds identified this mutation only in brown Havana rabbits.
The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype.
TYRP1-dependent miR-16 (zeige GDE1 Antikörper) sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16 (zeige GDE1 Antikörper)-binding sites on TYRP1 mRNA.
The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 (zeige GDE1 Antikörper).
DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively.
Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma.
Mutation in TYRP1 is associated with oculocutaneous albinism.
Polymorphisms in 3'UTR (zeige UTS2R Antikörper) of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR (zeige MLXIP Antikörper)-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR (zeige MLXIP Antikörper)-155 activity
These data suggest that UVB-stimulated Ucn1 (zeige UCN Antikörper) contributes to TRP1 (zeige PRSS1 Antikörper) production via the transcription of both Nurr-1 (zeige NR4A2 Antikörper) and Nur77 (zeige NR4A1 Antikörper). Ucn1 (zeige UCN Antikörper), produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.
These data indicate that galectin-3 (zeige LGALS3 Antikörper) is a regulatory component in melanin synthesis affecting the expression of Tyrp-1.
p53 (zeige TP53 Antikörper) regulation by TRP2 (zeige DCT Antikörper) is not pervasive in melanoma.
A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs.
Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R (zeige MSHR Antikörper) genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.
Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb.
the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 (zeige TRPC1 Antikörper) protein expression by post-transcriptional control in B16F10 cells
Studied upregulation by Kaliziri extract of tyrosinase (zeige TYR Antikörper), TRP-1 (zeige TRPC1 Antikörper), TRP-2 (zeige DCT Antikörper) and MITF (zeige MITF Antikörper) expression in murine B16 melanoma cells.
The SNARE (zeige VTI1B Antikörper) machinery composed of VAMP7 (zeige VAMP7 Antikörper) on Tyrp1-containing vesicles and syntaxin-3 (zeige STX3 Antikörper) and SNAP23 (zeige SNAP23 Antikörper) on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes.
Addition of a TRP-1 (zeige TRPC1 Antikörper)-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions.
analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage
GILT (zeige IFI30 Antikörper)-deficient mice have an increase in TRP1 (zeige TRPC1 Antikörper)-specific regulatory T (Treg) cells compared with TRP1 (zeige TRPC1 Antikörper)-deficient mice, and depletion of Treg cells partially restores the ability of GILT (zeige IFI30 Antikörper)-deficient TRP1 (zeige TRPC1 Antikörper)-specific CD4 (zeige CD4 Antikörper)(+) T cells to induce vitiligo (zeige MITF Antikörper).
The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions.
DNA vaccination with a melanoma-shared antigen Trp1 (zeige TRPC1 Antikörper), combined with systemic TGF-beta (zeige TGFB1 Antikörper) blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma.
both the Rab32 (zeige RAB32 Antikörper)/38 binding activity and VAMP7 (zeige VAMP7 Antikörper) binding activity of Varp (zeige ANKRD27 Antikörper) are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 (zeige RAB21 Antikörper) by the VPS9 domain is not necessary for Tyrp1 trafficking
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
5,6-dihydroxyindole-2-carboxylic acid oxidase
, DHICA oxidase
, catalase B
, glycoprotein 75
, melanoma antigen gp75
, tyrosinase-related protein 1
, tyrosinase-related protein-1
, Cosens-Manning mutant
, INAD localization-B
, transient photreceptor potential
, transient receptor potential protein
, tyrosine phosphatase 1, same as B (Brown)
, 5,6-dihydroxyindole-2-carboxylic acid oxidase-like
, brown locus protein
, iris stromal atrophy