anti-Tyrosinase-Related Protein 1 (TYRP1) Antikörper

Human Tyrosinase-Related Protein 1 (TYRP1) Interaktionspartner

1. The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype.

2. TYRP1-dependent miR-16 (zeige GDE1 Antikörper) sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16 (zeige GDE1 Antikörper)-binding sites on TYRP1 mRNA.

3. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 (zeige GDE1 Antikörper).

4. DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively.

5. Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma.

6. Mutation in TYRP1 is associated with oculocutaneous albinism.

7. Polymorphisms in 3'UTR (zeige UTS2R Antikörper) of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR (zeige MLXIP Antikörper)-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR (zeige MLXIP Antikörper)-155 activity

8. These data suggest that UVB-stimulated Ucn1 (zeige UCN Antikörper) contributes to TRP1 (zeige PRSS1 Antikörper) production via the transcription of both Nurr-1 (zeige NR4A2 Antikörper) and Nur77 (zeige NR4A1 Antikörper). Ucn1 (zeige UCN Antikörper), produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.

9. These data indicate that galectin-3 (zeige LGALS3 Antikörper) is a regulatory component in melanin synthesis affecting the expression of Tyrp-1.

10. p53 (zeige TP53 Antikörper) regulation by TRP2 (zeige DCT Antikörper) is not pervasive in melanoma.

Zebrafish Tyrosinase-Related Protein 1 (TYRP1) Interaktionspartner

1. a mutation in tyrp1A, one of the two tyrp1 paralogs in zebrafish, causes melanophore death leading to a semi-dominant phenotype

2. The Fugu tyrp1 promoter can direct transgene expression in a cell-type-specific manner in zebrafish. Our findings provide evidence supporting differential regulations of melanin-synthesizing genes in RPE (zeige RPE Antikörper) cells and the NCDM in zebrafish.

Fruit Fly (Drosophila melanogaster) Tyrosinase-Related Protein 1 (TYRP1) Interaktionspartner

1. results indicate that properties of the light-activated channels together with the dynamic light-dependent process of TRP (zeige trpl Antikörper) phosphorylation at the S936 site determine response kinetics

2. TRP (zeige trpl Antikörper) de-phosphorylation affects the detection limit of oscillating light in photoreceptor cells.

3. Data show that phosphorylation of most ransient receptor potential (TRP (zeige trpl Antikörper)) ion channel sites depends on the phototransduction cascade and the activity of the TRP (zeige trpl Antikörper).

4. TRP (zeige trpl Antikörper) and TRPL (zeige trpl Antikörper) assemble exclusively as homomultimeric channels in their native environment.

5. These results indicate that the Pain TRP (zeige trpl Antikörper) channels in the MBs (zeige NEU2 Antikörper) and IPCs control neuronal plasticity that is required for the formation of a certain type of long-lasting associative memory in Drosophila.

6. Vesicle exocytosis depends on cacophony, TRP (zeige trpl Antikörper) and TRPL (zeige trpl Antikörper).

7. members of the TRP (zeige trpl Antikörper) family are "special assignment" channels, which are recruited to diverse signaling pathways.

8. Single amino acid change in the fifth transmembrane segment of the TRP (zeige trpl Antikörper) Ca2 (zeige CA2 Antikörper)+ channel causes massive degeneration of photoreceptors.

9. Paper briefly overviews current knowledge of TRP and its mammalian homologues as non-voltage-gated Ca2+ channels that are constitutively active or gated by a multitude of stimuli; thus TRPs may play divergent roles in cell pathophysiology.

10. Data show that a substantial reduction of the TRP (zeige trpl Antikörper) channel protein by RNA interference completely rescues neuronal degeneration and significantly improves the light-elicited responses of the eye.

Cow (Bovine) Tyrosinase-Related Protein 1 (TYRP1) Interaktionspartner

1. Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R (zeige MSHR Antikörper) genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.

Pig (Porcine) Tyrosinase-Related Protein 1 (TYRP1) Interaktionspartner

1. A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs.

Rabbit Tyrosinase-Related Protein 1 (TYRP1) Interaktionspartner

1. we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1) and Tyrosinase (TYR (zeige TYR Antikörper)), as well as genes with unknown functions.

2. A mutation in exon 2 of the TYRP1 gene leads to a premature stop codon at position 190 of the deduced amino acid sequence. Genotyping 203 rabbits of 32 different breeds identified this mutation only in brown Havana rabbits.

Mouse (Murine) Tyrosinase-Related Protein 1 (TYRP1) Interaktionspartner

1. Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb.

2. the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 (zeige TRPC1 Antikörper) protein expression by post-transcriptional control in B16F10 cells

3. Studied upregulation by Kaliziri extract of tyrosinase (zeige TYR Antikörper), TRP-1 (zeige TRPC1 Antikörper), TRP-2 (zeige DCT Antikörper) and MITF (zeige MITF Antikörper) expression in murine B16 melanoma cells.

4. The SNARE (zeige VTI1B Antikörper) machinery composed of VAMP7 (zeige VAMP7 Antikörper) on Tyrp1-containing vesicles and syntaxin-3 (zeige STX3 Antikörper) and SNAP23 (zeige SNAP23 Antikörper) on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes.

5. Addition of a TRP-1 (zeige TRPC1 Antikörper)-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions.

6. analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage

7. GILT (zeige IFI30 Antikörper)-deficient mice have an increase in TRP1 (zeige TRPC1 Antikörper)-specific regulatory T (Treg) cells compared with TRP1 (zeige TRPC1 Antikörper)-deficient mice, and depletion of Treg cells partially restores the ability of GILT (zeige IFI30 Antikörper)-deficient TRP1 (zeige TRPC1 Antikörper)-specific CD4 (zeige CD4 Antikörper)(+) T cells to induce vitiligo (zeige MITF Antikörper).

8. The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions.

9. DNA vaccination with a melanoma-shared antigen Trp1 (zeige TRPC1 Antikörper), combined with systemic TGF-beta (zeige TGFB1 Antikörper) blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma.

10. both the Rab32 (zeige RAB32 Antikörper)/38 binding activity and VAMP7 (zeige VAMP7 Antikörper) binding activity of Varp (zeige ANKRD27 Antikörper) are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 (zeige RAB21 Antikörper) by the VPS9 domain is not necessary for Tyrp1 trafficking