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The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Zusätzlich bieten wir Ihnen TRPM2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 85 products:
Mouse (Murine) Polyclonal TRPM2 Primary Antibody für ICC, IHC (fro) - ABIN259658
Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. in Neurotoxicology 2010
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Human Polyclonal TRPM2 Primary Antibody für ICC, IHC (fro) - ABIN153042
Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Human Polyclonal TRPM2 Primary Antibody für ICC, IF - ABIN153041
Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. in Journal of medicinal chemistry 2013
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Polyclonal TRPM2 Primary Antibody für WB - ABIN540252
Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. in The Journal of biological chemistry 2003
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Mouse (Murine) Polyclonal TRPM2 Primary Antibody für ICC, IF - ABIN4362934
Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. in Scientific reports 2015
Results provide compelling evidence to support a role for nitrosative stress in linking the TRPM2 (zeige CLU Antikörper) turnover with the disturbance of autophagy in brain pericyte injury.
oxidative stress activates the TRPM2 (zeige CLU Antikörper)-Ca(2 (zeige CA2 Antikörper)+)-CAMK2 (zeige CAMK2B Antikörper) cascade to phosphorylate BECN1 (zeige BECN1 Antikörper) resulting in autophagy inhibition
We conclude from these studies that inhibition of ROS (zeige ROS1 Antikörper) production, and the subsequent abrogation of TRPM2 (zeige CLU Antikörper)-mediated Ca(2 (zeige CA2 Antikörper)+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.
oxidative stress activated the TRPM2 (zeige CLU Antikörper)-CaMKII (zeige CAMK2G Antikörper) cascade to further induce intracellular ROS (zeige ROS1 Antikörper) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential
The work summarized here shows that TRPM2 (zeige CLU Antikörper) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (zeige ROS1 Antikörper)
Activation of TRPM2 (zeige CLU Antikörper) channels, however, caused intracellular release of not only Ca(2 (zeige CA2 Antikörper)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (zeige CA2 Antikörper)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.
neutrophils sense reactive oxygen species via the TRPM2 (zeige CLU Antikörper) channel to arrest migration at their target site.
The inhibitory function of oxidant sensing by TRPM2 (zeige CLU Antikörper) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1 (zeige FPR1 Antikörper)) and subsequent FPR1 (zeige FPR1 Antikörper) internalization and signaling inhibition
findings demonstrate the important function of TRPM2 (zeige CLU Antikörper) in modulation of cell survival through mitochondrial ROS (zeige ROS1 Antikörper), and the potential of targeted inhibition of TRPM2 (zeige CLU Antikörper) as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.
Study demonstrate that PRL (zeige PRL Antikörper) is necessary for the survival of (retinal pigment epithelium) RPE (zeige RPE Antikörper) under normal and advancing age conditions and, identified SIRT2 (zeige SIRT2 Antikörper) and TRPM2 (zeige CLU Antikörper) as molecular targets for the antioxidant and antiapoptotic actions of PRL (zeige PRL Antikörper) in the RPE (zeige RPE Antikörper).
High TRPM2 to trigger lysosomal membrane permeabilization and Zn(2+)-mediated mitochondrial fission.
Trpm2 might promote hyperinflammation in Down Syndrome.
Studied the role of transient receptor potential melastatin 2 (zeige TRPM3 Antikörper) (TRPM2) in activating caspase-1 (zeige CASP1 Antikörper) and caspase-1 (zeige CASP1 Antikörper)-dependent pyroptosis in mouse BMDMs. Found TRPM2 knockout caused higher caspase-1 (zeige CASP1 Antikörper) activation and pyrotopsis.
Transient receptor potential melastatin-2 (TRPM2) in pituitary nerve terminals plays a role in oxytocin release. Temperature- enhanced oxytocin release by CD38 and TRPM2. TRPM2 might be involved in the process of CD38-regulated oxytocin release.
this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection
Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.
These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.
TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.
Lysophosphatidylcholine induces intracellular Ca(2 (zeige CA2 Antikörper)+) influx and increases phosphorylation of p38 MAPK (zeige MAPK14 Antikörper) via TRPM2, which in turn activates microglia.
The current study demonstrated that a physiological concentration of adrenaline attenuates insulin (zeige INS Antikörper) release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.
Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .
heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (zeige TRPC3 Antikörper) or TRPC7 protein induce enhanced receptor-activated Ca(2 (zeige CA2 Antikörper)+) influx that may lead to dysregulated cell growth in ADPKD
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
, estrogen-responsive element-associated gene 1 protein
, long transient receptor potential channel 2
, transient receptor potential cation channel subfamily M member 2
, transient receptor potential channel 7
, transient receptor potential melastatin family 2
, transient receptor potential cation channel, subfamily M, member 2
, transient receptor potential cation channel, subfamily C, member 7
, transient receptor potential cation channel, subfamily C, member 7-like
, short transient receptor potential channel 7-like
, transient receptor potential cation channel subfamily M member 2-like
, transient receptor protein 7
, transient receptor potential channel subfamily C member 7