anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Antikörper

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Zusätzlich bieten wir Ihnen TRPM2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TRPM2 7226 O94759
TRPM2 294329  
TRPM2 28240  
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Top anti-TRPM2 Antikörper auf antikoerper-online.de

Showing 10 out of 96 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Maus Kaninchen Unkonjugiert ICC, IHC (fro), IF, IHC, WB Staining of rat hippocampus using ABIN259658. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-TRPM2 antibody, IHC(P) IHC(P): Rat Brain Tissue Anti-TRPM2 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Mouse Brain Tissue Lysate Lane 3: Mouse Liver Tissue Lysate Lane 4: JURKAT Cell Lysate Lane 5: HELA Cell Lysate Lane 6: A549 Cell Lysate 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert IHC (p), IHC, WB Western Blot: TRPM2 Antibody [NBP1-33416] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE, antibody diluted at 1:500. Immunohistochemistry-Paraffin: TRPM2 Antibody [NBP1-33416] - Paraffin-embedded MDAMB468 xenograft, using antibody at 1:100 dilution. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Kaninchen Unkonjugiert ICC, IHC (fro), IF, IP, IHC, WB Western Blot: TRPM2 Antibody - Samples: Membrane Prep (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-TRPM2 antibody (lot was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Western Blot: TRPM2 Antibody - Samples: Jurkat Membrane Prep (50, 15, 5 ug). Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Ziege Unkonjugiert IHC, IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details
Meerschweinchen Kaninchen Unkonjugiert IHC, IHC (p), WB Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Heart, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$727.83
Details
Maus Kaninchen Unkonjugiert ICC, IF, WB Detection of TRPM2 in mouse brain membrane lysates using ABIN259771. Immunocytochemistry/Immunofluorescence: TRPM2 Antibody [ABIN2597714] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$415.44
Details
Maus Kaninchen DyLight 550 ICC, IF, IHC, IHC (fro), WB   0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Kaninchen Unkonjugiert ICC, IF, IP, WB Western Blot: TRPM2 Antibody [ABIN153041] - Membrane Prep (50 ug) from Jurkat cells. Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details

TRPM2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-TRPM2 Antikörper

  1. Mouse (Murine) Polyclonal TRPM2 Primary Antibody für ICC, IHC (fro) - ABIN259658 : Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. in Neurotoxicology 2010 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal TRPM2 Primary Antibody für ICC, IHC (fro) - ABIN153042 : Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal TRPM2 Primary Antibody für ICC, IF - ABIN153041 : Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. in Journal of medicinal chemistry 2013 (PubMed)
    Show all 2 Pubmed References

  4. Polyclonal TRPM2 Primary Antibody für WB - ABIN540252 : Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Polyclonal TRPM2 Primary Antibody für ICC, IF - ABIN4362934 : Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. in Scientific reports 2015 (PubMed)

Weitere Antikörper gegen TRPM2 Interaktionspartner

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaktionspartner

  1. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2 (zeige CYBB Antikörper)-dependent production of ROS (zeige ROS1 Antikörper), activation of TRPM2 (zeige CLU Antikörper) channels, rise in mitochondrial Zn(2+), Drp-1 (zeige CRMP1 Antikörper) recruitment and abnormal mitochondrial fission.

  2. TRPM2 (zeige CLU Antikörper) is essential for the survival and migration of squamous cell cancer cells.

  3. Results provide compelling evidence to support a role for nitrosative stress in linking the TRPM2 (zeige CLU Antikörper) turnover with the disturbance of autophagy in brain pericyte injury.

  4. oxidative stress activates the TRPM2 (zeige CLU Antikörper)-Ca(2 (zeige CA2 Antikörper)+)-CAMK2 (zeige CAMK2B Antikörper) cascade to phosphorylate BECN1 (zeige BECN1 Antikörper) resulting in autophagy inhibition

  5. We conclude from these studies that inhibition of ROS (zeige ROS1 Antikörper) production, and the subsequent abrogation of TRPM2 (zeige CLU Antikörper)-mediated Ca(2 (zeige CA2 Antikörper)+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.

  6. oxidative stress activated the TRPM2 (zeige CLU Antikörper)-CaMKII (zeige CAMK2G Antikörper) cascade to further induce intracellular ROS (zeige ROS1 Antikörper) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential

  7. The work summarized here shows that TRPM2 (zeige CLU Antikörper) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (zeige ROS1 Antikörper)

  8. Activation of TRPM2 (zeige CLU Antikörper) channels, however, caused intracellular release of not only Ca(2 (zeige CA2 Antikörper)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (zeige CA2 Antikörper)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

  9. neutrophils sense reactive oxygen species via the TRPM2 (zeige CLU Antikörper) channel to arrest migration at their target site.

  10. The inhibitory function of oxidant sensing by TRPM2 (zeige CLU Antikörper) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1 (zeige FPR1 Antikörper)) and subsequent FPR1 (zeige FPR1 Antikörper) internalization and signaling inhibition

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaktionspartner

  1. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2 (zeige CYBB Antikörper)-dependent production of ROS (zeige ROS1 Antikörper), activation of TRPM2 channels, rise in mitochondrial Zn(2+), Drp-1 (zeige CRMP1 Antikörper) recruitment and abnormal mitochondrial fission.

  2. High TRPM2 to trigger lysosomal membrane permeabilization and Zn(2+)-mediated mitochondrial fission.

  3. Trpm2 might promote hyperinflammation in Down Syndrome.

  4. Studied the role of transient receptor potential melastatin 2 (zeige TRPM3 Antikörper) (TRPM2) in activating caspase-1 (zeige CASP1 Antikörper) and caspase-1 (zeige CASP1 Antikörper)-dependent pyroptosis in mouse BMDMs. Found TRPM2 knockout caused higher caspase-1 (zeige CASP1 Antikörper) activation and pyrotopsis.

  5. Transient receptor potential melastatin-2 (TRPM2) in pituitary nerve terminals plays a role in oxytocin release. Temperature- enhanced oxytocin release by CD38 and TRPM2. TRPM2 might be involved in the process of CD38-regulated oxytocin release.

  6. this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection

  7. Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.

  8. These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.

  9. TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

  10. Lysophosphatidylcholine induces intracellular Ca(2 (zeige CA2 Antikörper)+) influx and increases phosphorylation of p38 MAPK (zeige MAPK14 Antikörper) via TRPM2, which in turn activates microglia.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaktionspartner

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (zeige TRPC3 Antikörper) or TRPC7 protein induce enhanced receptor-activated Ca(2 (zeige CA2 Antikörper)+) influx that may lead to dysregulated cell growth in ADPKD

TRPM2 Antigen-Profil

Protein Überblick

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Genbezeichner und Symbole assoziert mit TRPM2

  • transient receptor potential cation channel subfamily M member 2 (TRPM2) Antikörper
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) Antikörper
  • transient receptor potential cation channel subfamily C member 6 (TRPC6) Antikörper
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) Antikörper
  • transient receptor potential cation channel subfamily C member 7 (TRPC7) Antikörper
  • short transient receptor potential channel 7 (LOC100443123) Antikörper
  • short transient receptor potential channel 7 (LOC100539776) Antikörper
  • transient receptor potential cation channel subfamily M member 2 (trpm2) Antikörper
  • transient receptor potential cation channel subfamily M member 2 (Trpm2) Antikörper
  • 9830168K16Rik Antikörper
  • C79133 Antikörper
  • EREG1 Antikörper
  • KNP3 Antikörper
  • LTRPC2 Antikörper
  • NUDT9H Antikörper
  • NUDT9L1 Antikörper
  • si:ch73-263b18.1 Antikörper
  • Trp7 Antikörper
  • TRPC7 Antikörper
  • TRPM2 Antikörper
  • Trpm2-predicted Antikörper
  • Trrp7 Antikörper

Bezeichner auf Proteinebene für TRPM2

LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor potential melastatin family 2 , transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor protein 7 , transient receptor potential channel subfamily C member 7

GENE ID SPEZIES
7226 Homo sapiens
294329 Rattus norvegicus
424835 Gallus gallus
470101 Pan troglodytes
508029 Bos taurus
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
28240 Mus musculus
100271727 Sus scrofa
100720314 Cavia porcellus
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