anti-Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) Antikörper

SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Zusätzlich bieten wir Ihnen SLC7A11 Kits (14) und SLC7A11 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SLC7A11 23657 Q9UPY5
SLC7A11 310392  
SLC7A11 26570 Q9WTR6
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Top anti-SLC7A11 Antikörper auf antikoerper-online.de

Showing 10 out of 101 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert FACS, ICC, IF, IHC, IHC (p), SimWes, WB Detection of XCT in total human and mouse stomach lysate, respectively, using ABIN152648.  1 minute ECL exposure. XCT staining in the absorptive epithelia of intestinal villi detected using ABIN152648. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-SLC7A11 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>THP-1 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert ELISA, WB ABIN190899 (0.02µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Kaninchen Unkonjugiert ICC, IF, WB Immunocytochemistry/Immunofluorescence: xCT Antibody [ABIN152647] - xCT antibody was tested in HepG2 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Kaninchen Unkonjugiert IHC (p) Anti-SLC7A11 antibody  ABIN1049349 IHC staining of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details
Human Ziege Unkonjugiert IHC (p), ELISA, WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details
Hund Ziege Unkonjugiert IHC (p), WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$455.40
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: SLC7A11 Antibody [ABIN252942] - ABIN252942 (0.02ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Western Blot: xCT Antibody [ABIN2529425] - Analysis of SLC7A11 using this antibody at 0.02 ug/ml in Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human brain labeled with Anti-CCBR1 Polyclonal Antibody, Unconjugated (ABIN872924) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human kidney labeled with Anti-CCBR1 Polyclonal Antibody, Unconjugated (ABIN872924) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details

SLC7A11 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-SLC7A11 Antikörper

  1. Human Polyclonal SLC7A11 Primary Antibody für FACS, ICC - ABIN152648 : Liu, Blower, Pham, Fang, Dai, Wise, Green, Teitel, Ning, Ling, Lyn-Cook, Kadlubar, Sadée, Huang: Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. in Molecular pharmacology 2007 (PubMed)
    Show all 38 Pubmed References

  2. Human Polyclonal SLC7A11 Primary Antibody für ICC, IF - ABIN152647 : Pampliega, Domercq, Soria, Villoslada, Rodríguez-Antigüedad, Matute: Increased expression of cystine/glutamate antiporter in multiple sclerosis. in Journal of neuroinflammation 2011 (PubMed)
    Show all 4 Pubmed References

  3. Mouse (Murine) Polyclonal SLC7A11 Primary Antibody für IHC - ABIN967037 : Sato, Tamba, Ishii, Bannai: Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal SLC7A11 Primary Antibody für IHC (p) - ABIN2477153 : Choné, Menges, Wurster: [Leiomyoma of the esophagus with an epiphrenal diverticulum]. in RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 1978 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal SLC7A11 Primary Antibody für ELISA, WB - ABIN252942 : Zhang, Trachootham, Liu, Chen, Pelicano, Garcia-Prieto, Lu, Burger, Croce, Plunkett, Keating, Huang: Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. in Nature cell biology 2012 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen SLC7A11 Interaktionspartner

Human Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) Interaktionspartner

  1. miR (zeige MLXIP Antikörper)-375 served as a tumor suppressor via regulating SLC7A11.

  2. As targets of oncogenes with intrinsic tyrosine kinase (zeige TXK Antikörper) activity, STAT3 (zeige STAT3 Antikörper) and STAT5 (zeige STAT5A Antikörper) become constitutively active in hematologic neoplasms and solid tumors, promoting cell proliferation and survival and modulating redox homeostasis via regulation xCT expression. (Review)

  3. Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb (zeige NCAPG2 Antikörper)) through TLR2/Akt (zeige AKT1 Antikörper)- and p38 (zeige CRK Antikörper)-dependent signaling pathway.

  4. Genetic and pharmacological inhibition of xCT potentiated the cytotoxic effects of aspirin plus sorafenib; this effect was diminished by xCT overexpression. Low-dose aspirin plus sorafenib enhanced the cytotoxicity of cisplatin in resistant HNC (zeige MMP8 Antikörper) cells through xCT inhibition and oxidant and DNA damage.

  5. MUC1 (zeige MUC1 Antikörper)-C binds directly with CD44v and in turn promotes stability of xCT in the cell membrane

  6. simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR (zeige C12orf5 Antikörper) and SLC7A11. Moreover, p53 (zeige TP53 Antikörper)(4KR) is still capable of inducing the p53 (zeige TP53 Antikörper)-Mdm2 (zeige MDM2 Antikörper) feedback loop, but p53 (zeige TP53 Antikörper)-dependent ferroptotic responses are markedly abrogated

  7. ARF inhibits tumor growth by suppressing the ability of NRF2 (zeige GABPA Antikörper) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (zeige GRIN1 Antikörper) antiporter that regulates reactive oxygen species (ROS (zeige ROS1 Antikörper))-induced ferroptosis.

  8. Mechanistically, CD44v interacts with and stabilizes xCT and thereby promotes the uptake of cysteine for glutathione synthesis and stimulates side-population cell enrichment.

  9. ATF4 (zeige ATF4 Antikörper) expression fosters the malignancy of primary brain tumors and increases proliferation and tumor angiogenesis; experiments revealed that ATF4 (zeige ATF4 Antikörper)-dependent tumor promoting effects are mediated by transcriptional targeting the glutamate (zeige GRIN1 Antikörper) antiporter xCT

  10. Identify mTORC2 (zeige CRTC2 Antikörper) as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate (zeige GRIN1 Antikörper) antiporter xCT. mTORC2 (zeige CRTC2 Antikörper) phosphorylates serine 26 at the cytosolic N terminus of xCT, inhibiting its activity.

Mouse (Murine) Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11) Interaktionspartner

  1. Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb (zeige NCAPG2 Antikörper)) through TLR2/Akt (zeige AKT1 Antikörper)- and p38 (zeige CRK Antikörper)-dependent signaling pathway.

  2. Protein expression of xCT is enhanced in immune cells from an animal model of multiple sclerosis.

  3. Study suggests that mature astrocytes have low expression levels of xCT and that they do not depend on its function to survive. In contrast, oligodendrocytes, which express high levels of xCT, are the most vulnerable cell type of CNS to glutathione depletion upon chronic blockage of xCT or under oxidative glutamate (zeige GRIN1 Antikörper) toxicity.

  4. ARF inhibits tumor growth by suppressing the ability of NRF2 (zeige NFE2L2 Antikörper) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (zeige GRIN1 Antikörper) antiporter that regulates reactive oxygen species (ROS (zeige ROS1 Antikörper))-induced ferroptosis.

  5. Expression of xCT is reduced in astroglia in a genetic mouse model of susceptibility to depressive-like behavior.

  6. Data suggest that glucose starvation of various neoplasm cell lines induces Slc7a11 expression; Slc7a11 overexpression decreases intracellular glutamate (zeige GRIN1 Antikörper), an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate (zeige GRIN1 Antikörper), restores survival in Slc7a11-overexpressing neoplasm cell lines under glucose starvation.

  7. HIF-1alpha (zeige HIF1A Antikörper) plays a role in cerebral ischaemia-reperfusion -induced glutamate (zeige GRIN1 Antikörper) excitotoxicity via the long-lasting activation of system xc(-) -dependent glutamate (zeige GRIN1 Antikörper) outflow

  8. Results provided important insights into understanding the mechanism associated with xCT deficiency.

  9. Protein expression of xCT was observed throughout the forebrain and amygdala.

  10. Cerebellar astroglia isolated from Atm (zeige ATM Antikörper) mutant mice show decreased expression of the cystine/glutamate (zeige GRIN1 Antikörper) exchanger subunit xCT, glutathione reductase (zeige GSR Antikörper), and glutathione-S-transferase (zeige GSTa2 Antikörper)

SLC7A11 Antigen-Profil

Protein Überblick

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Genbezeichner und Symbole assoziert mit SLC7A11

  • solute carrier family 7 member 11 (SLC7A11) Antikörper
  • solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11) Antikörper
  • solute carrier family 7 member 11 (Slc7a11) Antikörper
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11) Antikörper
  • 9930009M05Rik Antikörper
  • AI451155 Antikörper
  • CCBR1 Antikörper
  • DKFZp468E122 Antikörper
  • SLC7A11 Antikörper
  • sut Antikörper
  • xCT Antikörper

Bezeichner auf Proteinebene für SLC7A11

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 , cystine/glutamate transporter , solute carrier family 7, member 11 , Cystine/glutamate transporter , cystine/glutamate transporter-like , solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 , amino acid transport system xc- , calcium channel blocker resistance protein CCBR1 , solute carrier family 7 member 11 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 , cysteine/glutamate transporter , sodium independent anionic amino acid transport system

GENE ID SPEZIES
428731 Gallus gallus
471310 Pan troglodytes
524078 Bos taurus
696516 Macaca mulatta
100027770 Monodelphis domestica
100049683 Sus scrofa
100091177 Ornithorhynchus anatinus
100172659 Pongo abelii
100386974 Callithrix jacchus
100581045 Nomascus leucogenys
23657 Homo sapiens
310392 Rattus norvegicus
483821 Canis lupus familiaris
26570 Mus musculus
Ausgewählte Anbieter für anti-SLC7A11 (SLC7A11) Antikörper
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