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SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. Zusätzlich bieten wir Ihnen SLC7A11 Kits (14) und SLC7A11 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SLC7A11 Primary Antibody für FACS, ICC - ABIN152648
Liu, Blower, Pham, Fang, Dai, Wise, Green, Teitel, Ning, Ling, Lyn-Cook, Kadlubar, Sadée, Huang: Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. in Molecular pharmacology 2007
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Human Polyclonal SLC7A11 Primary Antibody für ICC, IF - ABIN152647
Pampliega, Domercq, Soria, Villoslada, Rodríguez-Antigüedad, Matute: Increased expression of cystine/glutamate antiporter in multiple sclerosis. in Journal of neuroinflammation 2011
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Mouse (Murine) Polyclonal SLC7A11 Primary Antibody für IHC - ABIN967037
Sato, Tamba, Ishii, Bannai: Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. in The Journal of biological chemistry 1999
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Human Polyclonal SLC7A11 Primary Antibody für IHC (p) - ABIN2477153
Choné, Menges, Wurster: [Leiomyoma of the esophagus with an epiphrenal diverticulum]. in RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 1978
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Human Polyclonal SLC7A11 Primary Antibody für ELISA, WB - ABIN252942
Zhang, Trachootham, Liu, Chen, Pelicano, Garcia-Prieto, Lu, Burger, Croce, Plunkett, Keating, Huang: Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. in Nature cell biology 2012
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miR (zeige MLXIP Antikörper)-375 served as a tumor suppressor via regulating SLC7A11.
As targets of oncogenes with intrinsic tyrosine kinase (zeige TXK Antikörper) activity, STAT3 (zeige STAT3 Antikörper) and STAT5 (zeige STAT5A Antikörper) become constitutively active in hematologic neoplasms and solid tumors, promoting cell proliferation and survival and modulating redox homeostasis via regulation xCT expression. (Review)
Authors found that the xCT expression was increased in peripheral blood monocyte of active tuberculosis. xCT expression in macrophage was induced by Mycobacterium tuberculosis (Mtb (zeige NCAPG2 Antikörper)) through TLR2/Akt (zeige AKT1 Antikörper)- and p38 (zeige CRK Antikörper)-dependent signaling pathway.
Genetic and pharmacological inhibition of xCT potentiated the cytotoxic effects of aspirin plus sorafenib; this effect was diminished by xCT overexpression. Low-dose aspirin plus sorafenib enhanced the cytotoxicity of cisplatin in resistant HNC (zeige MMP8 Antikörper) cells through xCT inhibition and oxidant and DNA damage.
MUC1 (zeige MUC1 Antikörper)-C binds directly with CD44v and in turn promotes stability of xCT in the cell membrane
simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR (zeige C12orf5 Antikörper) and SLC7A11. Moreover, p53 (zeige TP53 Antikörper)(4KR) is still capable of inducing the p53 (zeige TP53 Antikörper)-Mdm2 (zeige MDM2 Antikörper) feedback loop, but p53 (zeige TP53 Antikörper)-dependent ferroptotic responses are markedly abrogated
ARF inhibits tumor growth by suppressing the ability of NRF2 (zeige GABPA Antikörper) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (zeige GRIN1 Antikörper) antiporter that regulates reactive oxygen species (ROS (zeige ROS1 Antikörper))-induced ferroptosis.
Mechanistically, CD44v interacts with and stabilizes xCT and thereby promotes the uptake of cysteine for glutathione synthesis and stimulates side-population cell enrichment.
ATF4 (zeige ATF4 Antikörper) expression fosters the malignancy of primary brain tumors and increases proliferation and tumor angiogenesis; experiments revealed that ATF4 (zeige ATF4 Antikörper)-dependent tumor promoting effects are mediated by transcriptional targeting the glutamate (zeige GRIN1 Antikörper) antiporter xCT
Identify mTORC2 (zeige CRTC2 Antikörper) as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate (zeige GRIN1 Antikörper) antiporter xCT. mTORC2 (zeige CRTC2 Antikörper) phosphorylates serine 26 at the cytosolic N terminus of xCT, inhibiting its activity.
Protein expression of xCT is enhanced in immune cells from an animal model of multiple sclerosis.
Study suggests that mature astrocytes have low expression levels of xCT and that they do not depend on its function to survive. In contrast, oligodendrocytes, which express high levels of xCT, are the most vulnerable cell type of CNS to glutathione depletion upon chronic blockage of xCT or under oxidative glutamate (zeige GRIN1 Antikörper) toxicity.
ARF inhibits tumor growth by suppressing the ability of NRF2 (zeige NFE2L2 Antikörper) to transcriptionally activate its target genes, including SLC7A11, a component of the cystine/glutamate (zeige GRIN1 Antikörper) antiporter that regulates reactive oxygen species (ROS (zeige ROS1 Antikörper))-induced ferroptosis.
Expression of xCT is reduced in astroglia in a genetic mouse model of susceptibility to depressive-like behavior.
Data suggest that glucose starvation of various neoplasm cell lines induces Slc7a11 expression; Slc7a11 overexpression decreases intracellular glutamate (zeige GRIN1 Antikörper), an alternative source of metabolic energy; provision of alpha-ketoglutarate, a key downstream metabolite of glutamate (zeige GRIN1 Antikörper), restores survival in Slc7a11-overexpressing neoplasm cell lines under glucose starvation.
HIF-1alpha (zeige HIF1A Antikörper) plays a role in cerebral ischaemia-reperfusion -induced glutamate (zeige GRIN1 Antikörper) excitotoxicity via the long-lasting activation of system xc(-) -dependent glutamate (zeige GRIN1 Antikörper) outflow
Results provided important insights into understanding the mechanism associated with xCT deficiency.
Protein expression of xCT was observed throughout the forebrain and amygdala.
Cerebellar astroglia isolated from Atm (zeige ATM Antikörper) mutant mice show decreased expression of the cystine/glutamate (zeige GRIN1 Antikörper) exchanger subunit xCT, glutathione reductase (zeige GSR Antikörper), and glutathione-S-transferase (zeige GSTa2 Antikörper)
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
, cystine/glutamate transporter
, solute carrier family 7, member 11
, Cystine/glutamate transporter
, cystine/glutamate transporter-like
, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
, amino acid transport system xc-
, calcium channel blocker resistance protein CCBR1
, solute carrier family 7 member 11
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
, cysteine/glutamate transporter
, sodium independent anionic amino acid transport system