anti-Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Antikörper

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. Zusätzlich bieten wir Ihnen Sodium Channel, Voltage-Gated, Type I, beta Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SCN1B 20266 P97952
SCN1B 29686 Q00954
SCN1B 6324 Q07699
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Top anti-Sodium Channel, Voltage-Gated, Type I, beta Antikörper auf antikoerper-online.de

Showing 10 out of 80 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SCN1B Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Hela cell lysate 100 μL 2 bis 3 Tage
$319.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Scn1b Antibody Titration: 1.0 ug/ml Positive Control: Rat Thymus 100 μL 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB Anti-SCN1B antibody, Western blotting All lanes: Anti SCN1B  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: HELA Whole Cell Lysate at 40ug Predicted bind size: 25KD Observed bind size: 25KD 100 μg 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert EIA, FACS, IHC (p), WB Flow Cytometric analysis of Hela cells using SCN1B Antibody (N-Term) Cat.-No AP53815PU-N (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue stained with SCN1B Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Anti-SCN1B antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this ... 100 μL 11 bis 14 Tage
$727.83
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis SCN1B using HepG2 whole cell lysates 100 μL 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert WB Western blot with SCN1B Polyclonal Antibody 0.1 mg 6 bis 8 Tage
$456.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane). SCN1B Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using SCN1B antibody. Western blot analysis of extracts of various cell lines, using SCN1B antibody (ABIN4905094) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s. 100 μL 11 bis 13 Tage
$366.77
Details

Weitere Antikörper gegen Sodium Channel, Voltage-Gated, Type I, beta Interaktionspartner

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Interaktionspartner

  1. This study demonstrated that the sodium channel beta1 subunit proteins encoded by this mutant gene are expressed at the surface of neuronal cell bodies.

  2. Loss of Scn1b caused increased amplitude of tetrodotoxin-sensitive INa, delayed after-depolarizations, triggered beats, changed Ca2+ transients,and susceptibility ventricular arrhythmias.

  3. Study showed that Scn1b is widely expressed at axon initial segments across the mouse brain, there is considerable heterogeneity in the proportion of Scn1b-positive neurons and the amount of expression between and within brain regions

  4. beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis

  5. Scn1b mutant subicular and layer 2/3 pyramidal neurons had increased action potential firing rates, presumably as a consequence of their increased input resistance

  6. Stronger expressions of SCN5a, SCN1b and Kir2.1 were observed in ventricular-like and atrial-like cells compared to that of pacemaker-like cardiomyocytes.

  7. Scn1b is critical for neuronal proliferation, migration, and pathfinding during the critical postnatal period of brain development.

  8. The results presented here identify Navbeta1 as a component of native neuronal Kv4.2-encoded I(A) channel complexes and a novel regulator of I(A) channel densities and neuronal excitability.

  9. Scn1b regulates the electrical excitability of nociceptive DRG neurons in vivo by modulating both I(Na) and I(K).

  10. propose reciprocity of function between Scn1b (beta1) and Na(v)1.6 such that beta1-mediated neurite outgrowth requires Na(v)1.6-mediated I(Na), and Na(v)1.6 localization and consequent high-frequency firing require beta1

  11. The primary sodium channels present in ventricular myocytes are composed of Na(v)1.5 plus beta2 and/or beta4 subunits in intercalated disks and Na(v)1.1, Na(v)1.3, and Na(v)1.6 plus beta1 and/or beta3 subunits in the transverse tubules.

  12. Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons

  13. Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b.

  14. Electrocardiograms from Scn1b knockout mice displayed longer heart rate intervals and extended long QT syndromes.

  15. Voltage-gated Na(+) channel beta1 subunits signal via multiple pathways on multiple timescales and play important roles in the postnatal development of the CNS

  16. Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion.

Human Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Interaktionspartner

  1. this study reports the cryo-electron microscopy structures of the human Nav1.7-beta1-beta2 complex bound to two combinations of pore blockers and gating modifier toxins (GMTs), tetrodotoxin with protoxin-II and saxitoxin with huwentoxin-IV, both determined at overall resolutions of 3.2 angstroms.

  2. our results show that the role of beta1 subunit on the maturation and expression of the entire NaCh complex is of paramount importance to understand the pathological conditions resulted from a defective interaction between the NaCh constituents.

  3. Genetic analysis was suggestive of SCN1B gene mutation associated with Dravet syndrome

  4. results show that the primary defect of E87Q mutation of the beta1 subunit is to compromise the correct voltage gated sodium channel maturation and traffic

  5. Scn1b and Fxyd1 expression was significantly downregulated in HSCR colon.

  6. The lack of genotype-phenotype concordance among families, combined with the high frequency of previously reported mutations in the Genome Aggregation Database browser, suggests that SCN1B is not a monogenic cause of BrS or SADS.

  7. we confirm the recessive inheritance of 2 novel SCN1B mutations in 5 children from 3 families with developmental epileptic encephalopathy. The recessive inheritance and early death in these patients is consistent with the Dravet-like phenotype observed in Scn1b(-/-) mice.

  8. This report provides the first genetic evidence of SCN1B mutation causing the Benign Familial Infantile Epilepsy (BFIE) phenotype.

  9. Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome.

  10. SCN1B gene mutations that reduce sodium channel current may provide a mechanistic link between Atrioventricular nodal reentrant tachycardia and Brugada syndrome and predispose to expression of both phenotypes.

  11. In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes.

  12. We also identified an SCN1B T189M variant in 2 probands with lone AF and in 1 of 250 control subjects.

  13. Study showed that the human SCN1B C121W epilepsy mutation leads to decreased axon initial segments expression of SCN1B in heterozygous CW mice and a complete lack of SCN1B in homozygous WW mice

  14. data revealed SCN1Bb as a susceptibility gene responsible for LQTS

  15. High SCN1B expression is associated with increased tumour growth and metastasis in breast cancer.

  16. Hippocampal networks of a NaV beta1 transgenic mouse model of genetic epilepsy show enhanced excitability.

  17. experimental data indicate that sodium channel voltage-gated type I beta subunit (Navbeta1b)/H162P results in reduced sodium channel activity functionally affecting the ventricular action potential.

  18. sodium channel polymorphisms are associated with epilepsy

  19. SCN1B mutation is not a common cause of Dravet syndrome.

  20. results suggest that R214Q variation in SCN1Bb is a functional polymorphism that may serve as a modifier of the substrate responsible for Brugada syndrome or SIDS phenotypes

Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) Antigen-Profil

Protein Überblick

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SCN1B

  • sodium channel, voltage-gated, type I, beta (Scn1b) Antikörper
  • sodium voltage-gated channel beta subunit 1 (Scn1b) Antikörper
  • sodium voltage-gated channel beta subunit 1 (SCN1B) Antikörper
  • GEFSP1 Antikörper

Bezeichner auf Proteinebene für SCN1B

sodium channel subunit beta-1 , sodium channel, voltage-gated, type I, beta polypeptide , sodium channel voltage-gated type 1 beta polypeptide , sodium channel voltage-gated type I beta polypeptide , sodium channel, voltage-gated, type 1, beta polypeptide , sodium channel beta-1 subunit , sodium channel beta 1-subunit

GENE ID SPEZIES
20266 Mus musculus
29686 Rattus norvegicus
6324 Homo sapiens
484584 Canis lupus familiaris
618204 Bos taurus
100009211 Oryctolagus cuniculus
747705 Pan troglodytes
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