Sclerostin Proteine (SOST)

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Zusätzlich bieten wir Ihnen Sclerostin Antikörper (128) und Sclerostin Kits (64) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top Sclerostin Proteine auf antikoerper-online.de

Showing 10 out of 18 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Human Cells Human His tag 50 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
Human Cells Ratte His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
HEK-293 Cells Human Biotin,His tag Biotinylated Human SOST on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 200 μg Anmelden zum Anzeigen 2 bis 3 Tage
$1,375.00
Details
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$522.50
Details
HEK-293 Cells Human His tag   0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$687.50
Details
Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
Details
Mammalian Cells Maus His tag   10 μg Anmelden zum Anzeigen 4 Days
$234.03
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,440.17
Details

SOST Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, ,
Mouse (Murine) , ,
,
Rat (Rattus) ,

Weitere Proteine zu Sclerostin (SOST) Interaktionspartnern

Human Sclerostin (SOST) Interaktionspartner

  1. Positivity of RANKL (zeige TNFSF11 Proteine) and anti-CCP2 yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (zeige TNFSF11 Proteine) or SOST was associated with increased concentrations of the factors.

  2. Osterix (zeige SP7 Proteine) and RUNX2 (zeige RUNX2 Proteine) are transcriptional regulators of sclerostin in human bone

  3. Sclerostin But Not Dickkopf-1 has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women

  4. An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (zeige COL1A2 Proteine).

  5. High serum levels of sclerostin and Dkk-1 (zeige DKK1 Proteine) are associated with acute ischaemic stroke

  6. The increased expression of sclerostin in the liver and the association with histologic cholangitis may explain the high serum levels of this protein in patients with primary biliary cirrhosis.

  7. SOST silencing promotes the proliferation, invasion and migration, and decreases the apoptosis of human retinoblastoma cells by activating the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway.

  8. Sclerostin concentrations in serum significantly decreased and IGF-I (zeige IGF1 Proteine) significantly increased after 12months of resistance training or JUMP.

  9. observed an association between sclerostin levels with fasting insulin (zeige INS Proteine) levels and homoeostatic model assessment-insulin (zeige INS Proteine) resistance, but there was no clear association with type 2 diabetes risk.

  10. Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR (zeige EGFR Proteine). Its involvement with other hormones of mineral homeostasis (FGF23 (zeige FGF23 Proteine)/Klotho (zeige KL Proteine) and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney

Mouse (Murine) Sclerostin (SOST) Interaktionspartner

  1. These results show that osteocytes and/or osteoblasts secrete factors regulating beige adipogenesis, at least in part, through the Wnt (zeige WNT2 Proteine)-signaling inhibitor sclerostin.

  2. In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (zeige GJA1 Proteine)+/-or Sost+/-mice

  3. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (zeige TNFSF11 Proteine) and SOST, leading to osteoclast inhibition and Wnt (zeige WNT2 Proteine) activation together.

  4. humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (zeige PFDN5 Proteine).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.

  5. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

  6. Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.

  7. complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.

  8. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  9. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  10. Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (zeige WNT2 Proteine) signaling pathway inhibition.

Sclerostin (SOST) Protein Überblick

Protein Überblick

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Genbezeichner und Symbole assoziert mit Sclerostin Proteine (SOST)

  • sclerostin (LOC100313724)
  • sclerostin (SOST)
  • sclerostin (Sost)
  • 5430411E23Rik Protein
  • CDD Protein
  • LOC100313724 Protein
  • VBCH Protein

Bezeichner auf Proteinebene für Sclerostin Proteine (SOST)

sclerostin , sclerosteosis

GENE ID SPEZIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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