Sclerostin Proteine (SOST)

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Zusätzlich bieten wir Ihnen Sclerostin Antikörper (140) und Sclerostin Kits (68) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top Sclerostin Proteine auf antikoerper-online.de

Showing 10 out of 21 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Human Cells Human His tag 50 μg Anmelden zum Anzeigen 14 bis 16 Tage
$382.80
Details
Human Cells Ratte His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
HEK-293 Cells Human Biotin,His tag Biotinylated Human SOST on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 200 μg Anmelden zum Anzeigen 2 bis 3 Tage
$1,375.00
Details
Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$522.50
Details
Human Cells Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,440.17
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,451.17
Details
Hefe REACT_Green monkey His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,454.83
Details

SOST Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine) , ,
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Rat (Rattus) , ,

Weitere Proteine zu Sclerostin (SOST) Interaktionspartnern

Human Sclerostin (SOST) Interaktionspartner

  1. Sclerosteosis is caused by loss-of-function mutations in the SOST gene which encodes a secreted glycoprotein, sclerostin--{REVIEW}

  2. Serum sclerostin level was not an independent predictor of mortality in Maintenance Hemodialysis Patients

  3. these results suggest a possible role of sclerostin in the identification of ankylosing spondylitis patients

  4. important role for SOST SNP rs1877632 and VDR SNPs rs10735810 and rs731236 in the pathophysiology of stress fracture

  5. In our cohort of pregnant women, sclerostin and DKK1 (zeige DKK1 Proteine) were not associated with any adverse metabolic profile, and possibly do not play relevant roles in the pathophysiology of gestational diabetes mellitus.

  6. Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%

  7. serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness

  8. The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.

  9. SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway

  10. No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.

Mouse (Murine) Sclerostin (SOST) Interaktionspartner

  1. The SOST gene inhibited the expression of COL1, OCN, and OPN (zeige SPP1 Proteine), reduced the activity of alkaline phosphatase, and increased the expression of LPL (zeige LPL Proteine) and PPARgamma (zeige PPARG Proteine).

  2. Since adipocytes do not produce sclerostin, these findings suggest an unexplored endocrine function for sclerostin that facilitates communication between the skeleton and adipose tissue.

  3. A microtubule-dependent mechanotransduction pathway that linked fluid shear stress to reactive oxygen species and calcium (Ca2 (zeige CA2 Proteine)+) signals that led to a reduction in sclerostin abundance in cultured osteocytes.

  4. osteoclast-derived LIF (zeige LIF Proteine) regulates bone turnover through sclerostin expression.

  5. our study provided histological evidences that sclerostin tends to be secreted in osteocytes of remodeled mature bone, while FGF23 (zeige FGF23 Proteine) would be differently synthesized in osteoblasts and osteocytes according to the developmental stages

  6. These results show that osteocytes and/or osteoblasts secrete factors regulating beige adipogenesis, at least in part, through the Wnt (zeige WNT2 Proteine)-signaling inhibitor sclerostin.

  7. In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (zeige GJA1 Proteine)+/-or Sost+/-mice

  8. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (zeige TNFSF11 Proteine) and SOST, leading to osteoclast inhibition and Wnt (zeige WNT2 Proteine) activation together.

  9. humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (zeige PFDN5 Proteine).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.

  10. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

Sclerostin (SOST) Protein Überblick

Protein Überblick

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Genbezeichner und Symbole assoziert mit Sclerostin Proteine (SOST)

  • sclerostin (LOC100313724)
  • sclerostin (SOST)
  • sclerostin (Sost)
  • 5430411E23Rik Protein
  • CDD Protein
  • LOC100313724 Protein
  • VBCH Protein

Bezeichner auf Proteinebene für Sclerostin Proteine (SOST)

sclerostin , sclerosteosis

GENE ID SPEZIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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