Sclerostin Proteine (SOST)

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

alle Proteine anzeigen Gen GeneID UniProt
Human SOST SOST 50964 Q9BQB4
Maus SOST SOST 74499 Q99P68
Ratte SOST SOST 80722 Q99P67
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Showing 10 out of 21 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human His tag 50 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Human Cells Ratte His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
HEK-293 Cells Human Biotin,His tag Biotinylated Human SOST on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 200 μg Anmelden zum Anzeigen 2 bis 3 Tage
$1,375.00
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Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$522.50
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,440.17
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,451.17
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Hefe REACT_Green monkey His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,454.83
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Human Maus His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$325.00
Details

Weitere Proteine zu Sclerostin (SOST) Interaktionspartnern

Human Sclerostin (SOST) Interaktionspartner

  1. In our cohort of pregnant women, sclerostin and DKK1 (zeige DKK1 Proteine) were not associated with any adverse metabolic profile, and possibly do not play relevant roles in the pathophysiology of gestational diabetes mellitus.

  2. Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%

  3. serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness

  4. The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.

  5. SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway

  6. No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.

  7. Positivity of RANKL (zeige TNFSF11 Proteine) and anti-CCP2 yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (zeige TNFSF11 Proteine) or SOST was associated with increased concentrations of the factors.

  8. Osterix (zeige SP7 Proteine) and RUNX2 (zeige RUNX2 Proteine) are transcriptional regulators of sclerostin in human bone

  9. Sclerostin But Not Dickkopf-1 has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women

  10. An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (zeige COL1A2 Proteine).

Mouse (Murine) Sclerostin (SOST) Interaktionspartner

  1. A microtubule-dependent mechanotransduction pathway that linked fluid shear stress to reactive oxygen species and calcium (Ca2 (zeige CA2 Proteine)+) signals that led to a reduction in sclerostin abundance in cultured osteocytes.

  2. osteoclast-derived LIF (zeige LIF Proteine) regulates bone turnover through sclerostin expression.

  3. our study provided histological evidences that sclerostin tends to be secreted in osteocytes of remodeled mature bone, while FGF23 (zeige FGF23 Proteine) would be differently synthesized in osteoblasts and osteocytes according to the developmental stages

  4. These results show that osteocytes and/or osteoblasts secrete factors regulating beige adipogenesis, at least in part, through the Wnt (zeige WNT2 Proteine)-signaling inhibitor sclerostin.

  5. In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (zeige GJA1 Proteine)+/-or Sost+/-mice

  6. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (zeige TNFSF11 Proteine) and SOST, leading to osteoclast inhibition and Wnt (zeige WNT2 Proteine) activation together.

  7. humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (zeige PFDN5 Proteine).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.

  8. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

  9. Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.

  10. complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.

Sclerostin (SOST) Protein Überblick

Protein Überblick

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Genbezeichner und Symbole assoziert mit Sclerostin Proteine (SOST)

  • sclerostin (LOC100313724)
  • sclerostin (SOST)
  • sclerostin (Sost)
  • 5430411E23Rik Protein
  • CDD Protein
  • LOC100313724 Protein
  • VBCH Protein

Bezeichner auf Proteinebene für Sclerostin Proteine (SOST)

sclerostin , sclerosteosis

GENE ID SPEZIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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