Sclerostin Protein (SOST) (His tag)
Kurzübersicht für Sclerostin Protein (SOST) (His tag) (ABIN7197841)
Target
Alle Sclerostin (SOST) Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Aufreinigungstag / Konjugat
- Dieses Sclerostin Protein ist gelabelt mit His tag.
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Verwendungszweck
- Recombinant Rat Sclerostin/SOST Protein (His Tag)
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Sequenz
- Met 1-Tyr 213
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Produktmerkmale
- A DNA sequence encoding the rat SOST (NP_085073.1) (Met 1-Tyr 213) was expressed, fused with a polyhistidine tag at the C-terminus.
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Sterilität
- 0.2 μm filtered
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Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Sclerostin (SOST) (AA 24-213) protein (His-Avi Tag)
SOST Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) (AA 24-213) (Active) protein (Biotin,His-Avi Tag)SOST Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Sclerostin (SOST) (AA 69-258) (Active) protein (His tag)SOST Spezies: Cynomolgus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Sclerostin (SOST) (AA 24-211) protein (His tag)SOST Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Sclerostin (SOST) (AA 24-213) protein (His tag,Biotin)SOST Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Lagerung
- 4 °C,-20 °C,-80 °C
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Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Haltbarkeit
- 12 months
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- Sclerostin (SOST)
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Andere Bezeichnung
- Sclerostin/SOST
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Hintergrund
- SOST,Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.
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Molekulargewicht
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Calculated MW: 23 kDa
Observed MW: 33 kDa
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NCBI Accession
- NP_085073
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UniProt
- A6HJF6
Target
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