Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) Proteine (RUNX1T1)

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Zusätzlich bieten wir Ihnen und RUNX1T1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
Ratte RUNX1T1 RUNX1T1 362489  
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Showing 4 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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RUNX1T1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartnern

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. PKM2 (zeige PKM Proteine) as a novel target of RUNX1 (zeige RUNX1 Proteine)-ETO and is specifically downregulated in RUNX1 (zeige RUNX1 Proteine)-ETO positive AML (zeige RUNX1 Proteine) patients, indicating that PKM2 (zeige PKM Proteine) level might have a diagnostic potential in RUNX1 (zeige RUNX1 Proteine)-ETO associated AML (zeige RUNX1 Proteine).

  2. The specific association of ZBTB7A (zeige ZBTB7A Proteine) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (zeige ZBTB7A Proteine) and the RUNX1 (zeige RUNX1 Proteine)/RUNX1T1 fusion protein has been reported.

  3. Data indicate miR (zeige MLXIP Proteine)-29b-1 as a regulator of the AML1 (zeige RUNX1 Proteine)-ETO protein (RUNX1 (zeige RUNX1 Proteine)-RUNX1T1), and that miR (zeige MLXIP Proteine)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  4. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1 (zeige RUNX1 Proteine)-ETO/THAP10 (zeige THAP10 Proteine)/miR (zeige MLXIP Proteine)-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 (zeige THAP10 Proteine) predicts a poor clinical outcome and represents a novel therapeutic target.

  5. RUNX1 (zeige RUNX1 Proteine)-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1 (zeige RUNX1 Proteine)-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  6. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (zeige TFF1 Proteine) are mechanistically connected to CEBPB (zeige CEBPB Proteine) and that cross-regulation between CEBPB (zeige CEBPB Proteine)-RUNX1t1-TFF1 (zeige TFF1 Proteine) plays an important role in gastric carcinogenesis.

  7. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  8. Leukaemogenesis by AML1 (zeige RUNX1 Proteine)-ETO requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Proteine) formation.

  9. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (zeige RUNX1 Proteine)-175) of AML1 (zeige RUNX1 Proteine)-ETO is consistent with its contribution to the activity of full-length AML1 (zeige RUNX1 Proteine)-ETO and is mediated through its direct association with the DNA-binding domain

  10. the AML1 (zeige RUNX1 Proteine)-ETO fusion protein increases the expression of SIRT1 (zeige SIRT1 Proteine), possibly by binding to the promoter region of SIRT1 (zeige SIRT1 Proteine) to activate its transcription in t(8;21) AML (zeige RUNX1 Proteine).

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. Results suggest that AML1 (zeige RUNX1 Proteine)/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (zeige TFF1 Proteine) are mechanistically connected to CEBPB (zeige CEBPB Proteine) and that cross-regulation between CEBPB (zeige CEBPB Proteine)-RUNX1t1-TFF1 (zeige TFF1 Proteine) plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1 (zeige RUNX1 Proteine)-ETO requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Proteine) formation.

  5. Data show that RUNX1 (zeige RUNX1 Proteine)-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1 (zeige RUNX1 Proteine)/ETO in primary murine progenitors was inhibited when Aes (zeige AES Proteine) was decreased or absent.

  7. AML1 (zeige RUNX1 Proteine)-ETO synergizes with an ICSBP (zeige IRF8 Proteine) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (zeige CEBPB Proteine) and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1 (zeige RUNX1 Proteine)-ETO C-terminal NCoR (zeige NCOR1 Proteine)/SMRT-interacting domain transforms AML1 (zeige RUNX1 Proteine)-ETO into a potent leukemogenic protein

  10. p15(Ink4b (zeige CDKN2B Proteine)) loss must be accompanied by additional oncogenic changes for RUNX1 (zeige RUNX1 Proteine)-ETO-associated AML (zeige RUNX1 Proteine) to develop

RUNX1T1 Protein Überblick

Protein Überblick

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1)
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L)
  • RUNX1 translocation partner 1 (RUNX1T1)
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1)
  • RUNX1 translocation partner 1 (Runx1t1)
  • AML1T1 Protein
  • Cbfa2t1 Protein
  • Cbfa2t1h Protein
  • CDR Protein
  • ETO Protein
  • MTG8 Protein
  • si:ch211-232j17.1 Protein
  • wu:fi14b07 Protein
  • zgc:154044 Protein
  • ZMYND2 Protein

Bezeichner auf Proteinebene für RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPEZIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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