anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Antikörper

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Zusätzlich bieten wir Ihnen RUNX1T1 Proteine (6) und RUNX1T1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
RUNX1T1 362489  
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Top anti-RUNX1T1 Antikörper auf antikoerper-online.de

Showing 10 out of 51 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-RUNX1T1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-RUNX1T1 Antibody Titration: 1.25ug/ml Positive Control: HepG2 cell lysate There is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2 Host: Rabbit Target Name: WT1 Sample Type: 721_B Antibody Dilution: 1.0ug/ml RUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert ChIP, ELISA 50 μL Anmelden zum Anzeigen 2 bis 3 Tage
$245.00
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Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Human Maus Unkonjugiert ELISA, IF, WB Western Blot analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 monoclonal antibody (M01), clone 5A12.Lane 1: RUNX1T1 transfected lysate(67.566 KDa).Lane 2: Non-transfected lysate. Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Hund Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Maus Unkonjugiert IF, WB Anti-RUNX1T1 mouse monoclonal antibody (ABIN2455775) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1 (RC222426). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1. 0.1 mL Anmelden zum Anzeigen Verfügbar
$482.90
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$305.71
Details

Am meisten referenzierte anti-RUNX1T1 Antikörper

  1. Human Polyclonal RUNX1T1 Primary Antibody für ELISA, WB - ABIN560189 : Abdelhaleem: RNA helicases: regulators of differentiation. in Clinical biochemistry 2005 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal RUNX1T1 Primary Antibody für IHC - ABIN965546 : Liu, Shen, Huynh, Klisovic, Rush, Ford, Yu, Becknell, Li, Liu, Vukosavljevic, Whitman, Chang, Byrd, Perrotti, Plass, Marcucci: Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. in Cancer research 2005 (PubMed)
    Show all 10 Pubmed References

Weitere Antikörper gegen RUNX1T1 Interaktionspartner

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. PKM2 (zeige PKM Antikörper) as a novel target of RUNX1 (zeige RUNX1 Antikörper)-ETO and is specifically downregulated in RUNX1 (zeige RUNX1 Antikörper)-ETO positive AML (zeige RUNX1 Antikörper) patients, indicating that PKM2 (zeige PKM Antikörper) level might have a diagnostic potential in RUNX1 (zeige RUNX1 Antikörper)-ETO associated AML (zeige RUNX1 Antikörper).

  2. The specific association of ZBTB7A (zeige ZBTB7A Antikörper) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (zeige ZBTB7A Antikörper) and the RUNX1 (zeige RUNX1 Antikörper)/RUNX1T1 fusion protein has been reported.

  3. Data indicate miR (zeige MLXIP Antikörper)-29b-1 as a regulator of the AML1 (zeige RUNX1 Antikörper)-ETO protein (RUNX1 (zeige RUNX1 Antikörper)-RUNX1T1), and that miR (zeige MLXIP Antikörper)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  4. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1 (zeige RUNX1 Antikörper)-ETO/THAP10 (zeige THAP10 Antikörper)/miR (zeige MLXIP Antikörper)-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 (zeige THAP10 Antikörper) predicts a poor clinical outcome and represents a novel therapeutic target.

  5. RUNX1 (zeige RUNX1 Antikörper)-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1 (zeige RUNX1 Antikörper)-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  6. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (zeige TFF1 Antikörper) are mechanistically connected to CEBPB (zeige CEBPB Antikörper) and that cross-regulation between CEBPB (zeige CEBPB Antikörper)-RUNX1t1-TFF1 (zeige TFF1 Antikörper) plays an important role in gastric carcinogenesis.

  7. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  8. Leukaemogenesis by AML1 (zeige RUNX1 Antikörper)-ETO requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Antikörper) formation.

  9. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (zeige RUNX1 Antikörper)-175) of AML1 (zeige RUNX1 Antikörper)-ETO is consistent with its contribution to the activity of full-length AML1 (zeige RUNX1 Antikörper)-ETO and is mediated through its direct association with the DNA-binding domain

  10. the AML1 (zeige RUNX1 Antikörper)-ETO fusion protein increases the expression of SIRT1 (zeige SIRT1 Antikörper), possibly by binding to the promoter region of SIRT1 (zeige SIRT1 Antikörper) to activate its transcription in t(8;21) AML (zeige RUNX1 Antikörper).

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. Results suggest that AML1 (zeige RUNX1 Antikörper)/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (zeige TFF1 Antikörper) are mechanistically connected to CEBPB (zeige CEBPB Antikörper) and that cross-regulation between CEBPB (zeige CEBPB Antikörper)-RUNX1t1-TFF1 (zeige TFF1 Antikörper) plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1 (zeige RUNX1 Antikörper)-ETO requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Antikörper) formation.

  5. Data show that RUNX1 (zeige RUNX1 Antikörper)-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1 (zeige RUNX1 Antikörper)/ETO in primary murine progenitors was inhibited when Aes (zeige AES Antikörper) was decreased or absent.

  7. AML1 (zeige RUNX1 Antikörper)-ETO synergizes with an ICSBP (zeige IRF8 Antikörper) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (zeige CEBPB Antikörper) and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1 (zeige RUNX1 Antikörper)-ETO C-terminal NCoR (zeige NCOR1 Antikörper)/SMRT-interacting domain transforms AML1 (zeige RUNX1 Antikörper)-ETO into a potent leukemogenic protein

  10. p15(Ink4b (zeige CDKN2B Antikörper)) loss must be accompanied by additional oncogenic changes for RUNX1 (zeige RUNX1 Antikörper)-ETO-associated AML (zeige RUNX1 Antikörper) to develop

RUNX1T1 Antigen-Profil

Protein Überblick

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) Antikörper
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L) Antikörper
  • RUNX1 translocation partner 1 (RUNX1T1) Antikörper
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) Antikörper
  • RUNX1 translocation partner 1 (Runx1t1) Antikörper
  • AML1T1 Antikörper
  • Cbfa2t1 Antikörper
  • Cbfa2t1h Antikörper
  • CDR Antikörper
  • ETO Antikörper
  • MTG8 Antikörper
  • si:ch211-232j17.1 Antikörper
  • wu:fi14b07 Antikörper
  • zgc:154044 Antikörper
  • ZMYND2 Antikörper

Bezeichner auf Proteinebene für RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPEZIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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