anti-Paired-Like Homeobox 2b (PHOX2B) Antikörper

The DNA-associated protein encoded by PHOX2B is a member of the paired family of homeobox proteins localized to the nucleus. Zusätzlich bieten wir Ihnen PHOX2B Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PHOX2B 8929 Q99453
PHOX2B 18935 O35690
PHOX2B 364152  
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Top anti-PHOX2B Antikörper auf

Showing 10 out of 54 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: Phox2b Sample Type: Rat Stomach lysates Antibody Dilution: 1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Maus Kaninchen Unkonjugiert IF, WB PHOX2B Antibody (Center) (ABIN655288) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the PHOX2B antibody detected the PHOX2B protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Human Kaninchen Unkonjugiert EIA, WB   0.4 mL Anmelden zum Anzeigen 12 bis 15 Tage
Human Ziege Unkonjugiert ELISA, WB   0.1 mg Anmelden zum Anzeigen 6 bis 7 Tage
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
Huhn Ziege Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
Human Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using PHOX2B antibody. 100 μL Anmelden zum Anzeigen 16 Days
Human Kaninchen Unkonjugiert ELISA, WB Western Blot: PHOX2B Antibody [NBP2-41179] - Western blot analysis of PHOX2B in 293 cell lysate with PHOX2B antibody at (A) 1 and (B) 2 ug/mL. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
Maus Kaninchen Unkonjugiert IF, ELISA, WB Fluorescent image of U251 cell stained with PHOX2B antibody. Alexa Fluor 488 conjugated secondary (green) was used. Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin. PHOX2B immunoreactivity is localized to the nucleus. PHOX2B antibody western blot analysis in mouse liver tissue lysate 0.4 mL Anmelden zum Anzeigen 2 bis 3 Tage

PHOX2B Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-PHOX2B Antikörper

  1. Human Polyclonal PHOX2B Primary Antibody für ELISA - ABIN449850 : McGaughey, Vinton, Huynh, Al-Saif, Beer, McCallion: Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. in Genome research 2008 (PubMed)

  2. Mouse (Murine) Polyclonal PHOX2B Primary Antibody für IF, WB - ABIN655288 : Burbach, Hellemons, Grant, Pant: The homeodomain transcription factor Phox2 in the stellate ganglion of the squid Loligo pealei. in Biology open 2015 (PubMed)

Weitere Antikörper gegen PHOX2B Interaktionspartner

Zebrafish Paired-Like Homeobox 2b (PHOX2B) Interaktionspartner

  1. reduced dosage of PHOX2B during development, through either a heterozygous deletion or dominant-negative mutation, imposes a block in the differentiation of sympathetic neuronal precursors

  2. Phox2b is expressed throughout the primary taste centers of two cyprinid fish, Danio rerio and Carassius auratus

  3. Phox2b function is sox10 (zeige SOX10 Antikörper)-dependent in the developing enteric nervous system

Human Paired-Like Homeobox 2b (PHOX2B) Interaktionspartner

  1. The discovery of gain-of-function mutations in the ALK (zeige ALK Antikörper) receptor tyrosine kinase (zeige RET Antikörper) gene as the major cause of familial neuroblastoma (zeige ARHGEF16 Antikörper) led to the discovery of identical somatic mutations and rapid advancement of ALK (zeige ALK Antikörper) as a tractable therapeutic target. Inactivating mutations in a master regulator of neural crest development, PHOX2B, have also been identified in a subset of familial neuroblastomas.

  2. Given the association between congenital heart disease and aberrant neural crest cell development, however, findings are suggestive that congenital heart disease may be a rare feature of PHOX2B mutation which has not been previously reported

  3. This study is the first to evaluate minimal residual disease detection using neuroblastoma (zeige ARHGEF16 Antikörper) mRNAs in human ovarian tissue. Only PHOX2B was a reliable marker of neuroblastoma (zeige ARHGEF16 Antikörper) cells contaminating ovarian tissue.

  4. This truncated protein localized to the nucleus and transactivated a target promoter. These data suggest that nonsense pathogenic variants in the first exon of PHOX2B likely escape nonsense mediated decay (NMD) and produce N-terminally truncated proteins functionally distinct from those produced by the more common polyalanine repeat mutations (PARMs).

  5. These pre-clinical data strongly suggest that PHOX2B functions as a suppressor of neuroblastoma (zeige ARHGEF16 Antikörper) progression.

  6. High PHOX2B expression is associated with Neuroblastoma (zeige ARHGEF16 Antikörper).

  7. PHOX2B forms homodimers and heterodimerizes weakly with mutated proteins, excluding the direct involvement of the polyalanine tract in dimer formation, indicating that mutated proteins retain partial ability to form heterodimers with PHOX2A (zeige PHOX2A Antikörper).

  8. Expression of NOX4 (zeige NOX4 Antikörper)/p22(phox (zeige CYBA Antikörper)) as well as ROS (zeige ROS1 Antikörper) production is enhanced by IL-1beta (zeige IL1B Antikörper). On the other hand, the use of NOX4 (zeige NOX4 Antikörper) inhibitors decreased IL-1beta (zeige IL1B Antikörper)-induced collagenase synthesis by chondrocytes.

  9. PHOX2A (zeige PHOX2A Antikörper) expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation.

  10. Point "silent" mutations affecting different nucleotides of the PHOX2B gene were observed in 32 % of patients with Class III malocclusion and never in controls (0 %).

Mouse (Murine) Paired-Like Homeobox 2b (PHOX2B) Interaktionspartner

  1. Murine models of congenital central hypoventilation syndrome designed with PHOX2B mutations have suggested RTN neuron agenesis.

  2. The retrotrapezoid nucleus neurons expressing Atoh1 (zeige ATOH1 Antikörper) and Phox2b are essential for the respiratory response to CO2.

  3. Adult Phox2b(+/-) mice showed altered exploratory behavior in the open field and in the elevated plus maze, both indicative of anxiety. Phox2b(+/-) mice did not show cognitive or motor impairments.

  4. many cranial nerve-associated crest cells coexpress the pan (zeige SUPT6H Antikörper)-autonomic determinant Paired-like homeodomain 2b (Phox2b) together with markers of Schwann cell precursors. Some give rise to Schwann cells after down-regulation of PHOX2b.

  5. In this review, conditional mouse mutants of Phox2b(27Ala) lacked the ventilary response to hypercapnia at birth.

  6. Phox2b transcripts were identified in FAC (zeige FANCC Antikörper)-sorted Pitx3 (zeige PITX3 Antikörper) positive neurons.

  7. This study demonistrated that Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2.

  8. Nonpolyalanine repeat expansion mutation of PHOX2B is both a dominant-negative and gain-of-function mutation.

  9. The PHOX2B can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.

  10. The cranial sensory pathways, somatic and visceral, are related, and Phox2b serves as a developmental switch from the former to the latter.

PHOX2B Antigen-Profil

Protein Überblick

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.

Genbezeichner und Symbole assoziert mit PHOX2B

  • paired-like homeobox 2b (phox2b) Antikörper
  • paired like homeobox 2b S homeolog (phox2b.S) Antikörper
  • paired-like homeobox 2bb (phox2bb) Antikörper
  • paired like homeobox 2b (PHOX2B) Antikörper
  • paired like homeobox 2b (phox2b) Antikörper
  • paired-like homeobox 2b (Phox2b) Antikörper
  • Dilp1 Antikörper
  • NBLST2 Antikörper
  • NBPhox Antikörper
  • phox2 Antikörper
  • PHOX2B Antikörper
  • Pmx2b Antikörper
  • xphox2b Antikörper

Bezeichner auf Proteinebene für PHOX2B

paired-like homeobox 2b , paired mesoderm homeobox protein 2B , PHOX2B homeodomain protein , neuroblastoma Phox , neuroblastoma paired-type homeobox protein , paired mesoderm homeobox 2b , GENA 269 , dilated pupils 1

402787 Xenopus laevis
495120 Xenopus laevis
544654 Danio rerio
701940 Macaca mulatta
739088 Pan troglodytes
100124329 Xenopus (Silurana) tropicalis
8929 Homo sapiens
18935 Mus musculus
395548 Gallus gallus
610284 Canis lupus familiaris
783703 Bos taurus
364152 Rattus norvegicus
Ausgewählte Anbieter für anti-PHOX2B (PHOX2B) Antikörper
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