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Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability (By similarity). Zusätzlich bieten wir Ihnen PARP1 Binding Protein Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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PARI is a latent modulator of stalled fork processing, which is required for stable genome inheritance under both endogenous and exogenous replication stress
PARI inhibits homologous recombination in vivo, and its knockdown suppresses the UV sensitivity of RAD18 (zeige RAD18 Antikörper)-depleted cells
PARI overexpression promotes genomic instability and pancreatic tumorigenesis.
Knockdown of C12orf48 by siRNA in HeLa cells significantly suppressed their growth
PARI suppresses inappropriate recombination events at mammalian replication forks.
Demonstrated that C12orf48 protein could directly interact with Poly(ADP-ribose) Polymerase-1 (PARP-1 (zeige PARP1 Antikörper)). Knockdown of C12orf48 by siRNA in PDAC cells significantly suppressed their growth.
Parpbp(4930547N16Rik) is strongly co-expressed with known cancer-associated genes.
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability (By similarity).
PARP-1 binding protein
, PARP1-binding protein
, PCNA-interacting partner
, antisense RNA overlapping MCH gene protein