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MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. Zusätzlich bieten wir Ihnen MCC Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal MCC Primary Antibody für IHC (f), IF - ABIN968147
Ashton-Rickardt, Wyllie, Bird, Dunlop, Steel, Morris, Piris, Romanowski, Wood, White: MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer. in Oncogene 1991
Show all 5 Pubmed References
The PDZ domain protein (zeige INADL Antikörper) Mcc is a novel effector of non-canonical Wnt (zeige WNT2 Antikörper) signaling during convergence and extension in zebrafish.
Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene (zeige RAB1A Antikörper) in B cells
cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 (zeige SIRT1 Antikörper)
targeted by miR (zeige MLXIP Antikörper)-494, which is overexpressed in hepatocellular carcinoma
MCC regulates lamellipodia formation by binding to Scrib (zeige SCRIB Antikörper) and its downstream partner Myosin-IIB (zeige MYH10 Antikörper) in a multiprotein complex.
we have shown that promoter methylation of the APC (zeige APC Antikörper) gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.
Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.
MCC is a nuclear, beta-catenin-interacting protein (zeige CTNNBIP1 Antikörper) that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signal transduction.
Results identify MCC as a potential scaffold protein (zeige HOMER1 Antikörper) regulating cell movement and able to bind Scrib (zeige SCRIB Antikörper), beta-catenin (zeige CTNNB1 Antikörper) and NHERF1 (zeige SLC9A3R1 Antikörper)/2.
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
mutated in colorectal cancers
, colorectal mutant cancer protein