anti-Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Antikörper

The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MKL1 57591 Q969V6
MKL1 315151  
MKL1 223701 Q8K4J6
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Top anti-MKL1 Antikörper auf antikoerper-online.de

Showing 10 out of 81 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-MKL1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>NIH/3T3 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Mkl1 Antibody [NBP1-88498] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: Mkl1 Antibody [NBP1-88498] - Immunohistochemical staining of human placenta shows strong nuclear positivity in decidual cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Maus Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HuvEc/HeLa cells, using MKL1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert WB Immunohistochemistry of paraffin-embedded mouse brain using MKL1 antibody. Immunohistochemistry of paraffin-embedded rat brain using MKL1 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details
Human Kaninchen Unkonjugiert WB MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert IHC (p), WB <b>Western blot</b> (WB) analysis of MRTF-A antibody in extracts from HUVEC cells. 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details

MKL1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-MKL1 Antikörper

  1. Human Polyclonal MKL1 Primary Antibody für ICC, IF - ABIN4334827 : Schmidt, Duncan, Yadav, Regan, Verone, Lohse, Pop, Attwood, Wilding, Mohler, Sebo, Tindall, Heemers: RhoA as a mediator of clinically relevant androgen action in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2012 (PubMed)
    Show all 5 Pubmed References

Weitere Antikörper gegen MKL1 Interaktionspartner

Human Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Interaktionspartner

  1. MRTF-A is required for proliferation and formation of mammary acini from luminal epithelial cells. Conversely, elevated MRTF activity results in pre-malignant spheroid formation due to defective proliferation, polarity loss and epithelial-mesenchymal transition.

  2. MRTF-A regulated the transcriptional activity of Nrf2 (zeige GABPA Antikörper) by forming a complex with SRF binding to the CarG box which existed on Nrf2 (zeige GABPA Antikörper) promoter region, increasing the resistance of tumor cells to doxorubicin.

  3. Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK (zeige PTK2 Antikörper)-dependent regulation of cell migration.

  4. The identification of the miR (zeige MLXIP Antikörper)-206/TWF1 (zeige TWF1 Antikörper)/MKL1-SRF/IL11 (zeige IL11 Antikörper) signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis

  5. Herein, we propose a new ILK (zeige ILK Antikörper)-MMP9 (zeige MMP9 Antikörper)-MRTF axis that appears to be critical for endothelial-mesenchymal transition differentiation of endothelial to cancer-associated fibroblasts -like cells. Thus, it might be an attractive target for cancer treatment

  6. CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.

  7. HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.

  8. TNF-alpha (zeige TNF Antikörper) and LPS (zeige IRF6 Antikörper) promoted the interaction between MKL1 and PCAF (zeige KAT2B Antikörper).

  9. MRTF-A-miR (zeige MLXIP Antikörper)-206-WDR1 (zeige WDR1 Antikörper) form feedback loop to regulate breast cancer cell migration.

  10. miR (zeige MLXIP Antikörper)-93-5p regulates myocardin-like (zeige MYOCD Antikörper) 1 and STAT3 (zeige STAT3 Antikörper) to affect epithelial-mesenchymal transition controlling breast cancer cell migration

Cow (Bovine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Interaktionspartner

  1. beta-catenin (zeige CTNNB1 Antikörper) controls myocardin (zeige MYOCD Antikörper)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.

Mouse (Murine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Interaktionspartner

  1. these data indicate that Emerin (zeige EMD Antikörper), a conserved nuclear lamina protein, couples extracellular matrix mechanics and SRF-Mkl1-dependent transcription.

  2. Among a group of tumor cells, there is correlation between activation of the MRTF-dependent transcription and activated FAK (zeige PTK2 Antikörper)-dependent regulation of cell migration.

  3. Here, the authors show that Rho-dependent MRTF phosphorylation reflects its nuclear accumulation and dissociation from G-actin (zeige ACTB Antikörper), and identify multiple sites for MRTF phosphorylation, which contribute to transcriptional activation.

  4. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  5. knockdown of MKL1 induces a significant increase in the transcriptional activity of PPARgamma (zeige PPARG Antikörper) target genes and MKL1 interacts with PPARg (zeige PPARG Antikörper), suggesting that SRF and MKL1 independently inhibit brown adipogenesis and that MKL1 exerts its effect mainly by modulating PPARgamma (zeige PPARG Antikörper) activity

  6. further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 (zeige NFkBP65 Antikörper) during the transcription process. In an Abeta (zeige APP Antikörper) injection AD mouse model, animals orally administrated hypericin (50 mg/kg) for seven days significantly decreased pro-inflammatory cytokines expression and NO production in hippocampus, meanwhile, hypericin improved oAbeta42-induced learning and memory...

  7. Study demonstrates that WH2 domains activate MRTF-A and contribute to target gene regulation by a competitive mechanism, independently of their role in actin filament formation.

  8. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA (zeige RHOA Antikörper)/MRTF-A luciferase reporter.

  9. MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta (zeige TGFB1 Antikörper) signaling pathway in HSCs

  10. Exploration of the molecular causes of enhanced cardiac hypertrophy revealed significant activation of beta-catenin/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

MKL1 Antigen-Profil

Protein Überblick

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Genbezeichner und Symbole assoziert mit MKL1

  • megakaryoblastic leukemia (translocation) 1 (MKL1) Antikörper
  • megakaryoblastic leukemia 1 protein (mkl1) Antikörper
  • megakaryoblastic leukemia (translocation) 1 (Mkl1) Antikörper
  • megakaryoblastic leukemia (translocation) 1 S homeolog (mkl1.S) Antikörper
  • MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1) Antikörper
  • AI852829 Antikörper
  • AMKL Antikörper
  • AW743281 Antikörper
  • AW821984 Antikörper
  • Bsac Antikörper
  • Mal Antikörper
  • MKL1 Antikörper
  • Mrtf-A Antikörper
  • mrtfa Antikörper

Bezeichner auf Proteinebene für MKL1

megakaryoblastic leukemia 1 protein , MKL/myocardin-like protein 1 , RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein , basic, SAP and coiled-coil domain , megakaryocytic acute leukemia protein , myocardin-related transcription factor A , xMRTF-A , basic SAP and coiled-coil domains , basic SAP coiled-coil transcription activator , megakaryoblastic leukemia (translocation) 1 homolog , megakaryoblastic leukemia 1 protein homolog

GENE ID SPEZIES
745765 Pan troglodytes
100358994 Oryctolagus cuniculus
100510767 Anolis carolinensis
418005 Gallus gallus
57591 Homo sapiens
509011 Bos taurus
315151 Rattus norvegicus
398403 Xenopus laevis
223701 Mus musculus
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