anti-Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) Antikörper

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. Zusätzlich bieten wir Ihnen Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Proteine (14) und Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KLRC1 29683  
KLRC1 3821 P26715
KLRC1 16641  
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Top anti-Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Antikörper auf antikoerper-online.de

Showing 10 out of 116 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB 100 μL 2 bis 3 Tage
$289.00
Details
Meerschweinchen Kaninchen Unkonjugiert WB 100 μL 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB Western blot analysis of KLRC1 Antibody (C-term) (ABIN652569) in Jurkat cell line lysates (35 µg/lane). KLRC1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human kidney carcinoma with KLRC1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 200 μL 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert EIA, IF, WB Confocal immunofluorescent analysis of KLRC1 / CD159a Antibody (N-term) Cat.-No AP52396PU-N with MDA-MB435 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue). Western blot analysis of KLRC1 / CD159a Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the KLRC1 antibody detected the KLRC1 protein (arrow). 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using KLRC1, antibody at 1:200 dilution. IHC-P Image KLRC1 antibody [N1N2], N-term detects KLRC1 protein at cytosol on H1299 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded H1299 xenograft. KLRC1 antibody [N1N2], N-term , dilution: 1:500. 100 μL 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert WB   200 μL 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IF, WB KLRC1 Antibody (N-term) (ABIN656501) western blot analysis in MDA-MB435 cell line lysates (35 µg/lane). This demonstrates the KLRC1 antibody detected the KLRC1 protein (arrow). 400 μL 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of KLRC1 Antibody (C-term) in Jurkat cell line lysates (35ug/lane). KLRC1 (arrow) was detected using the purified Pab. 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB ABIN6275872 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11 bis 12 Tage
$390.77
Details

Am meisten referenzierte anti-Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Antikörper

  1. Human Monoclonal KLRC1 Primary Antibody für FACS - ABIN4898770 : Kruse, Hamann, Monecke, Cyganek, Elsner, Hübscher, Walter, Streckfuss-Bömeke, Guan, Dressel: Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1. in PLoS ONE 2015 (PubMed)
    Show all 13 Pubmed References

  2. Human Monoclonal KLRC1 Primary Antibody für CyTOF, FACS - ABIN4900827 : Brando, Mukhopadhyay, Kovacs, Medina, Patel, Catina, Campbell, Santoli: Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104. in Journal of leukocyte biology 2005 (PubMed)
    Show all 6 Pubmed References

  3. Human Monoclonal KLRC1 Primary Antibody für FACS - ABIN4898763 : Gill, Peppa, Micco, Singh, Carey, Foster, Maini, Kennedy: Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo. in PLoS pathogens 2016 (PubMed)
    Show all 5 Pubmed References

  4. Mouse (Murine) Polyclonal KLRC1 Primary Antibody für IF (p), IHC (p) - ABIN739875 : Hall, Murphy, Quinlan, Hurley, Shanahan, Nally, Melgar: Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor. in Mucosal immunology 2013 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal KLRC1 Primary Antibody für FACS - ABIN4898766 : Curriu, Carrillo, Massanella, Rigau, Alegre, Puig, Garcia-Quintana, Castro-Marrero, Negredo, Clotet, Cabrera, Blanco: Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome. in Journal of translational medicine 2013 (PubMed)

Weitere Antikörper gegen Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Interaktionspartner

Human Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) Interaktionspartner

  1. Increased HLA-E expression contributes to persistence of senescent cells in tissues via interaction with the inhibitory receptor NKG2A expressed by NK and highly differentiated CD8(+) T cells to inhibit immune responses against senescent cells.

  2. Compared with NKG2D, NKG2A expressed on both peripheral CD3-CD56+NK cells and CD3+CD8+T cells plays a more pivotal negative regulatory role in the progression of HBV-related ACLF.

  3. These results indicate NKG2A inhibitory receptor may play a key role in transfusion-induced immunodepression of NK cells in patients with b-thalassemia major

  4. Collectively, these results provide evidence for the first time that CD94/NKG2C is involved in chronic graft-versus-host disease prevention

  5. CD94 and NKG2A polymorphisms may contribute to genetic susceptibility to rheumatoid arthritis or affect the response to anti-TNF therapy in patients of Caucasian origin.

  6. NK cell maturation to CD56(dim) subset associated with high levels of NCRs overrides the inhibitory effect of NKG2A and recovers impaired NK cell cytolytic potential after allogeneic hematopoietic stem cell transplantation.

  7. Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.

  8. The presence of TIM3+and/or NKG2A+ T cells is associated with the absence of recurrences and a longer recurrence-free survival.

  9. Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

  10. Results suggested that the low expression level of CD94/NKG2A upon gammadelta T cell activation might lead to the over-activation of gammadelta T cells in patients with SLE.

  11. The positive expression rate of NKG2D and NKG2A on NK cells and CD3(+) T cells in ALL patients was no significantly different from that in AML patients.

  12. The level of NKG2A expression on resting CD8-positive T cells inversely correlated with acquisition of regulatory function when activated.

  13. These results suggested that these glycans can interact with NKG2D and CD94 to modulate NK cell-dependent cytotoxicity.

  14. The differences of CD94 and NKG2 expression between nasal NK/T-cell lymphomas and B cell lymphoma or T cell lymphoma were statistically significant.

  15. NKG2A expression on gammadelta lymphoproliferative Disease of Large Granular Lymphocytes correlates with asymptomatic pathology, even in the presence of NKG2C coexpression.

  16. CD56(dim) NK cells continue to differentiate. During this process, they lose expression of NKG2A, sequentially acquire inhibitory killer cell inhibitory immunoglobulin-like receptors and CD57.

  17. a new model in which the NK cell differentiation and functional fate are based on a stepwise decrease of NKG2A and acquisition of KIRs

  18. NK cell NKG2A expression is dysregulated in chronic hepatitis C. NKG2A-positive NK cells are associated with a beneficial response to pegylated interferon and ribavirin therapy.

  19. Results sugges that KLRC1 can be a probable candidate gene for SLE on 12p12.3-13.2, but which is not associated with the disease activity.

  20. alloreactivity of a significant fraction of KIR(-) NK cells leads to killing of acute myelogenous leukemia and acute lymphoblastic leukemia blasts that is mediated by NKG2A and LIR-1.

Mouse (Murine) Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) Interaktionspartner

  1. Liver cNK cells' hyporesponsiveness to stimulation through activating receptors is independent of IL-10, but correlates with decreased NKG2A expression compared to trNK cells.

  2. Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis.

  3. NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection.

  4. Results demonstrate the immunoregulatory role of CD8(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance.

  5. role in NK cell-mediated protection from DSS-induced colitis

  6. Endogenous NKG2A contributes to the rejection of cells lacking human HLA-Cw3.

  7. The complex interplay between various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo.

  8. expression of CD94 and its associated NKG2A, NKG2C, and NKG2E subunits is dispensable for NK cell development, education, and many NK cell functions

  9. The NKG2A+KLRG1+ positive phenotype correlates with protective efficacy during antigenic recall from a pool of CD8 T cells during persistent gamma-herpesvirus 68 infection.

  10. Data suggest that the liver environment regulates NK cell receptor expression and that IL-10 contributes to the regulation of liver NK cells, in part, by maintaining a greater percentage of the hyporesponsive NKG2A(+)Ly49(-) NK cells in the liver.

  11. Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.

  12. the CD94/NKG2A inhibitory receptor plays a critical role in down-regulating invariant NK-cell responses

  13. results indicate that LTbetaR-mediated signals are not required for Ly49 and CD94/NKG2 receptor acquisition on NK cells

  14. An NKG2B isoform paired with a CD94 alternatively spliced transcript may contribute to the plasticity of the natural killer cell immunological synapse by insuring an adequate inhibitory signal.

  15. NKG2A-expressing anti-polyoma virus CD8 T cells appear to be essential for antigen-specific recall responses in mice persistently infected by polyoma virus.

  16. Qa-1-NKG2A interaction protected activated CD4+ T cells from lysis by a subset of NKG2A+ natural-killer cells

  17. CD94/NKG2A transduces a biologically important signal in vivo to activated CD8+ T cells that limits immunopathology in severe influenza infection.

  18. genetic disruption of the Qa-1-CD94/NKG2A interaction unleashes robust CD8 Treg cell activity that completely abolishes development of experimental allergic encephalomyelitis

Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) Antigen-Profil

Protein Überblick

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.

Genbezeichner und Symbole assoziert mit KLRC1

  • killer cell lectin like receptor C1 (Klrc1) Antikörper
  • killer cell lectin like receptor C1 (KLRC1) Antikörper
  • NKG2-A/NKG2-B type II integral membrane protein-like (NKG2A) Antikörper
  • killer cell lectin-like receptor subfamily C, member 3 (KLRC3) Antikörper
  • killer cell lectin-like receptor subfamily C, member 1 (KLRC1) Antikörper
  • killer cell lectin-like receptor subfamily C, member 1 (Klrc1) Antikörper
  • CD159a Antikörper
  • KLRC1 Antikörper
  • NKG2 Antikörper
  • NKG2-A Antikörper
  • NKG2A Antikörper
  • NKG2B Antikörper
  • rNKG2A Antikörper

Bezeichner auf Proteinebene für KLRC1

natural killer cell protein group 2-A (NKG2A) , CD159 antigen-like family member A , NK cell receptor A , NKG2-A/B-activating NK receptor , NKG2-A/NKG2-B type II integral membrane protein , killer cell lectin-like receptor subfamily C, member 1 , C-lectin type II protein , NKG2-1/B activating NK receptor , NKG2-A/B type II integral membrane protein , natural killer cell lectin , natural killer group protein 2

GENE ID SPEZIES
29683 Rattus norvegicus
450131 Pan troglodytes
514897 Bos taurus
611325 Canis lupus familiaris
100126720 Papio anubis
100144622 Sus scrofa
3821 Homo sapiens
16641 Mus musculus
574146 Macaca mulatta
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