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FAP belongs to the serine protease family.
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Adora2B (zeige ADORA2B Antikörper) stimulation promotes FGF2 (zeige FGF2 Antikörper) and CXCL12 (zeige CXCL12 Antikörper) expression in FAP-positive melanoma-associated (zeige ZNF654 Antikörper) fibroblasts, contributing to the creation of a tumor-promoting microenvironment.
There was no evidence of compensatory upregulation of other DPP4 (zeige DPP4 Antikörper) family members in influenza-infected FAP-deficient mice. FAP appears to be dispensable in anti-influenza adaptive immunity.
FAP-STAT3 (zeige STAT3 Antikörper)-CCL2 (zeige CCL2 Antikörper) signaling in Cancer-associated fibroblasts (CAF (zeige LAMA2 Antikörper)) was sufficient to program an inflammatory component of the tumor microenvironment, which may have particular significance in desmoplasia-associated cancers.
Taken together, our study suggested that high FAP expression in CAFs (zeige TBX1 Antikörper) is one reason leading to immune checkpoint blockades resistance in CRC (zeige SCRIB Antikörper) patients and FAP is an optional target for reversing immune checkpoint blockades resistance.
FAP-vaccinated mice also treated with Cyclophosphamide chemotherapy showed a marked suppression of tumor growth (inhibition ratio =80%) and a prolongation of survival time.
In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.
Mouse FGF-21 (zeige FGF21 Antikörper), however, lacks the FAP cleavage site and is not cleaved by FAP.
Data indicate that indolamine-2,3-dioxygenase (IDO (zeige IDO1 Antikörper)) and Fibroblast activation protein alpha (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.
A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.
The FAP(+) stromal cell may have roles in two adverse consequences of cancer.
This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available.
fibroblast activation protein alpha
, integral membrane serine protease