anti-Fibroblast Activation Protein (FAP) Antikörper

FAP belongs to the serine protease family.

Alle Antikörper anzeigen Gen GeneID UniProt
FAP 14089 P97321
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Maus Kaninchen Unkonjugiert ELISA, WB Western blot using affinity purified anti-FAP antibody shows detection of FAP protein in whole cell lysates from FAP expressing HEK cells (lane 4) but not control HEK cells (lane 3).  Specific band staining is blocked when the primary antibody is pre-incubated with immunizing peptide (lanes 1 and 2 respectively).  The band at ~90 kDa, indicated by the arrowhead, corresponds to the expected molecular weight of transfected FAP. Primary antibody was used at 1:1,000.   ELISA results of purified Rabbit anti-Fibroblast Activation Protein (FAP) Antibody tested against BSA-conjugated peptide of immunizing peptide. Each well was coated in duplicate with 0.1µg of conjugate. The starting dilution of antibody was 5μg/ml and the X-axis represents the Log10 of a 3-fold dilution. This titration is a 4-parameter curve fit where the IC50 is defined as the titer of the antibody. Assay performed using 3% fish gel, Goat anti-Rabbit IgG Antibody Peroxidase Conjugated (Min X Bv Ch Gt GP Ham Hs Hu Ms Rt & Sh Serum Proteins)  and TMB ELISA Peroxidase Substrate . 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
Maus Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 16 Tage
Human Maus Unkonjugiert FACS, IP, IHC   100 μg Anmelden zum Anzeigen 11 bis 16 Tage

FAP Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Mouse (Murine)


Weitere Antikörper gegen Fibroblast Activation Protein Interaktionspartner

Mouse (Murine) Fibroblast Activation Protein (FAP) Interaktionspartner

  1. the uptake of the tracer in the joints reflects increased FAP expression during subclinical synovitis and that these joints will show symptoms of inflammation upon disease progression

  2. Adora2B (zeige ADORA2B Antikörper) stimulation promotes FGF2 (zeige FGF2 Antikörper) and CXCL12 (zeige CXCL12 Antikörper) expression in FAP-positive melanoma-associated (zeige ZNF654 Antikörper) fibroblasts, contributing to the creation of a tumor-promoting microenvironment.

  3. There was no evidence of compensatory upregulation of other DPP4 (zeige DPP4 Antikörper) family members in influenza-infected FAP-deficient mice. FAP appears to be dispensable in anti-influenza adaptive immunity.

  4. FAP-STAT3 (zeige STAT3 Antikörper)-CCL2 (zeige CCL2 Antikörper) signaling in Cancer-associated fibroblasts (CAF (zeige LAMA2 Antikörper)) was sufficient to program an inflammatory component of the tumor microenvironment, which may have particular significance in desmoplasia-associated cancers.

  5. Taken together, our study suggested that high FAP expression in CAFs (zeige TBX1 Antikörper) is one reason leading to immune checkpoint blockades resistance in CRC (zeige SCRIB Antikörper) patients and FAP is an optional target for reversing immune checkpoint blockades resistance.

  6. FAP-vaccinated mice also treated with Cyclophosphamide chemotherapy showed a marked suppression of tumor growth (inhibition ratio =80%) and a prolongation of survival time.

  7. In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.

  8. Mouse FGF-21 (zeige FGF21 Antikörper), however, lacks the FAP cleavage site and is not cleaved by FAP.

  9. Data indicate that indolamine-2,3-dioxygenase (IDO (zeige IDO1 Antikörper)) and Fibroblast activation protein alpha (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.

  10. A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.

Fibroblast Activation Protein (FAP) Antigen-Profil

Protein Überblick

This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available.

Genbezeichner und Symbole assoziert mit FAP

  • fibroblast activation protein (Fap) Antikörper

Bezeichner auf Proteinebene für FAP

fibroblast activation protein alpha , integral membrane serine protease , seprase

14089 Mus musculus
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