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CLECL1 encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells.
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C-type lectin-like molecule-1 (zeige CLEC12A Antikörper) is expressed in 86.5% of cases of acute myeloid leukemia (zeige BCL11A Antikörper), in 54.5% of acute myeloid leukemia (zeige BCL11A Antikörper) CD34positiveCD38negative stem cells, but not in acute lymphoblastic leukemia blast cells.
DCAL-1, highly expressed on dendritic cells and B lymphocytes, acts as a T cell costimulatory molecule (zeige CD276 Antikörper) which skews CD4 (zeige CD4 Antikörper)+ T cells toward a Th2 response by enhancing their secretion of IL-4 (zeige IL4 Antikörper).
incubation of immature DCs (iDCs) with an anti-DCAL-1 monoclonal antibody (mAb) induced downstream signaling, including phosphorylation of c-Jun N-terminal kinase (JNK) and p44 (zeige GTF2H2 Antikörper)/42 MAP kinase (zeige MAPK1 Antikörper).
This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
C-type lectin-like domain family 1
, DC-associated lectin-1
, dendritic cell associated lectin 1
, dendritic cell-associated lectin 1
, dendritic cell-associated lectin-1
, type II transmembrane protein DCAL1
, C-type lectin-like 1