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The protein encoded by AP3M1 is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures.
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Structural basis for the recognition of tyrosine-based sorting signals by the mu3A subunit of the AP-3 adaptor complex
Data indicate that AP-3 facilitates PAR1 (zeige MARK2 Antikörper) interaction with ALIX (zeige PDCD6IP Antikörper).
results demonstrate that the intact and stable AP-3 complex is required for HIV-1 assembly and release, and the involvement of the AP-3 complex in late stages of the HIV-1 replication cycle is independent of clathrin-mediated endocytosis
The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia.
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed.
AP-3 adapter complex mu3A subunit
, AP-3 complex subunit mu-1
, adapter-related protein complex 3 mu-1 subunit
, clathrin adaptor complex AP3, mu-3A subunit
, mu-adaptin 3A
, adaptor-related protein complex AP-3, mu 1 subunit
, clathrin adaptor protein mu3A
, HA1 47 kDa subunit homolog 1
, Mu-adaptin 3A
, adaptor-related protein complex AP-3 mu 1 subunit
, clathrin assembly protein assembly protein complex 1 medium chain homolog 1
, clathrin coat assembly protein AP47 homolog 1
, clathrin coat-associated protein AP47 homolog 1
, clathrin-associated adaptor protein homolog (p47A)
, golgi adaptor AP-1 47 kDa protein homolog 1