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ADAMTS13 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Zusätzlich bieten wir Ihnen ADAMTS13 Kits (41) und ADAMTS13 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ADAMTS13 Primary Antibody für WB - ABIN152016
Tao, Wang, Choi, Bernardo, Nishio, Sadler, López, Dong: Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow. in Blood 2005
Show all 5 Pubmed References
Human Polyclonal ADAMTS13 Primary Antibody für IP, WB - ABIN251718
Feng, Eyler, Zhang, Maga, Nester, Kroll, Smith, Afshar-Kharghan: Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome. in Blood 2013
Show all 2 Pubmed References
Human Polyclonal ADAMTS13 Primary Antibody für WB - ABIN251717
Turner, Nolasco, Ruggeri, Moake: Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. in Blood 2009
ADAMTS 1 (zeige ADAMTS1 Antikörper), 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1 (zeige ADAMTS1 Antikörper), 4, and 12 levels in placental tissues were higher in the preeclampsia group.
Decreased ADAMTS-13 activity was found in patients with proliferative lupus nephritis, and plasma ADAMTS-13 activity was closely associated with renal injury indices.
These results suggest that highly elevated plasma VWF (zeige VWF Antikörper) might accelerate platelet thrombus formation not only in the circulation but also on the surface of vascular endothelial cells in the setting of ADAMTS13 deficiency in Upshaw-Schulman syndrome.
Prothrombotic state and systemic inflammation status might contribute to explaining the high incidence of concealed chronic renal failure in COPD (zeige ARCN1 Antikörper), and plasma ADAMTS-13 levels may serve as a strong predictor.
VWF (zeige VWF Antikörper), GMP-140 (zeige SELP Antikörper), ADAMTS13 and the cerebral vasospasm, delayed cerebral ischemia, tumor diameter and prognosis of aneurysmal subarachnoid hemorrhage patients are closely related
The levels of ADAMTS13 among neonates were higher as compared with healthy adults, despite a significant elevation of VWF (zeige VWF Antikörper) antigen (Ag) and Ristocetin cofactor (RiCof) noted in all neonates.
investigated the roles of ADAMTS13 and VWF (zeige VWF Antikörper) in thrombotic events of patients with Connective Tissue Diseases
Studied the significance of the von Willebrand factor (VWF (zeige VWF Antikörper))/ ADAMTS-13 ratio in advanced non-small-cell lung cancer (NSCLC). Findings suggest that the imbalance between VWF (zeige VWF Antikörper) secretion and ADAMTS-13 may play a role in the hypercoagulability state in advanced NSCLC, and increase of the plasma VWF (zeige VWF Antikörper)/ADAMTS-13 ratio may serve as an independent predictive factor for mortality in patients with advanced NSCLC.
vaso-occlusive crisis in sickle cell disease is associated with increased reactivity of VWF (zeige VWF Antikörper), without a pronounced ADAMTS-13 deficiency
The endogenous plasmin (zeige PLG Antikörper) activation alone is not sufficient to cause Thrombotic thrombocytopenic purpura (TTP), but plasmin (zeige PLG Antikörper) activation with ADAMTS13 deficiency might increase the risk of TTP onset.
ADAMTS13-vWF (zeige VWF Antikörper) axis is partially involved in the pathophysiology of kidney ischemic reperfusion injury.
Adamts13 deficiency in obese mice promotes hepatic microthrombosis.
results suggest that ADAMTS13 controls key steps of ischemic vascular remodeling and that recombinant ADAMTS13 is a putative therapeutic avenue for promoting stroke recovery.
ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF (zeige VWF Antikörper)-dependent intrarenal thrombosis.
administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA (zeige PLAT Antikörper)-resistant thrombi resulting in fast restoration of MCA (zeige RSPH1 Antikörper) patency and consequently reduced cerebral infarct sizes
Sleeping beauty transposon-mediated gene therapy achieved sustained expression of transgene ADAMTS13 and long-term prophylaxis against congenital thrombotic thrombocytopenic purpura in Adamts13(-/-) mice.
Results also suggest that Toxoplasma gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of toxoplasma encephalitis. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease.
Letter: deficiency of ADAMTS13 results in increased formation of venous thrombosis in mice.
ADAMTS13 substrate specificity
Data indicate that the p.D187H mutation impairs ADAMTS13 activity and secretion and may contribute to thrombotic thrombocytopenic purpura.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
ADAM metallopeptidase with thrombospondin type 1 motif, 13
, A disintegrin and metalloproteinase with thrombospondin motifs 13
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
, vWF-cleaving protease
, von Willebrand factor-cleaving protease
, ADAM-TS 13
, ADAMTS13 isoform IAP-b
, vWF-CP mRNA for von Willebrand factor-cleaving
, ADAM metallopeptidase with thrombospondin type 1 motif, 13 isoform 1 preproprotein-like
, A disintegrin and metalloproteinase with thrombospondin motifs 13-like
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13