anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) Antikörper

ADAMTS13 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Zusätzlich bieten wir Ihnen ADAMTS13 Kits (28) und ADAMTS13 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ADAMTS13 11093 Q76LX8
ADAMTS13 279028 Q769J6
ADAMTS13 102554393  
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Top anti-ADAMTS13 Antikörper auf antikoerper-online.de

Showing 10 out of 91 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Immunohistochemistry: ADAMTS13 antibody staining of Formalin-Fixed Paraffin-Embedded Human hepatocarcinoma followed by peroxidase-conjugation to the secondary antibody and DAB staining. Western blot analysis: ADAMTS13 antibody staining of CEM cell line lysates (35 µg/lane). ADAMTS13 (arrow) was detected using the purified Pab. 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of ADAMTS13 expression in rat brain extract ( Lane 1), mouse liver extract ( Lane 2) and HEPG2 whole cell lysates ( Lane 3). ADAMTS13 at 154KD was detected using rabbit anti- ADAMTS13 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB Western blot analysis of ADAMTS13 using HeLa whole cell lysates ABIN6279085 at 1/100 staining Human melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-ADAMTS13 Antibody in CEM cell line lysates (35ug/lane) Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADAMTS13 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL 2 bis 3 Tage
$515.63
Details
Human Ziege Unkonjugiert IHC, IHC (p), WB Anti-ADAMTS13 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μL 11 bis 14 Tage
$639.83
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Used in DAB staining on fromalin fixed paraffin- embedded liver tissue 100 μg 13 bis 16 Tage
$240.00
Details
Human Maus Unkonjugiert IF, ELISA, WB   100 μg 11 bis 14 Tage
$1,013.83
Details
Human Maus Unkonjugiert ELISA, WB   100 μg 11 bis 14 Tage
$1,189.83
Details
Human Schaf Biotin WB   50 μg 11 bis 14 Tage
$1,255.83
Details
Human Maus Unkonjugiert FACS, IP, ELISA, WB   100 μg 11 bis 14 Tage
$1,013.83
Details

Am meisten referenzierte anti-ADAMTS13 Antikörper

  1. Human Polyclonal ADAMTS13 Primary Antibody für WB - ABIN152016 : Tao, Wang, Choi, Bernardo, Nishio, Sadler, López, Dong: Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow. in Blood 2005 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal ADAMTS13 Primary Antibody für IP, WB - ABIN251718 : Feng, Eyler, Zhang, Maga, Nester, Kroll, Smith, Afshar-Kharghan: Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome. in Blood 2013 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal ADAMTS13 Primary Antibody für WB - ABIN251717 : Turner, Nolasco, Ruggeri, Moake: Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. in Blood 2009 (PubMed)

Weitere Antikörper gegen ADAMTS13 Interaktionspartner

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) Interaktionspartner

  1. ADAMTS-13 level was decreased in children with severe typical HUS and its deficiency correlated with disease severity.

  2. A novel insight into mechano-chemical regulation on interaction between ADAMTS13 and vWF A2 domain under forces is provided.

  3. higher VWF and low ADAMTS13 activity are associated with increased risk of dementia

  4. Data confirm the critical role of exosite engagement for substrates to gain access to the active site of ADAMTS13, and define the substrate recognition motif for ADAMTS13.

  5. Trp(390) residue within the WXXW motif is required for ADAMTS13 secretion and enzymatic activity

  6. ADAMTS13 open-closed conformations regulate the activity of this highly specific VWF cleaving protease in thrombotic thrombocytopenic purpura [review]

  7. analysis of a follow-up study showing higher mortality or thrombotic complications and increased platelet count, increased VWF:Ag levels and decreased ADAMTS13 activity in colorectal cancer

  8. relative plasma deficiency of ADAMTS13 activity may be associated with more severe traumatic injury, significant endothelial glycocalyx damage, coagulation abnormalities and mortality after severe trauma in paediatric patients

  9. Low ADAMTS-13 activity is a predictor of unfavourable outcome in patients with ischaemic stroke undergoing endovascular therapy

  10. analysis of ADAMTS13 variants in a patient cohort with Upshaw-Schulman Syndrome investigated in Germany

  11. Through its action on VWF, ADAMTS13 can have prothrombotic and proinflammatory properties, not only when its activity is severely deficient, but also when it is only moderately low.

  12. An open ADAMTS-13 conformation is also a hallmark of acute acquired thrombotic thrombocytopenic purpura, altering autoantibody binding.

  13. truncation of ADAMTS13 by plasmin abolishes intramolecular self-association, which improves interaction with unfolded von Willebrand Factor

  14. antigen and activity both positively correlated with plasma viral load in HIV infection

  15. protein C and ADAMTS-13 change were associated with outcome in an ongoing endothelial/hemostatic disorder was during sepsis

  16. Upshaw-Schulman Syndrome With c.2728C>T Mutation in ADAMTS13 Gene.

  17. ADAMTS13 rs2285489 genotyping in transplant recipients may be a useful tool for evaluating pretransplantation risks.

  18. Genetic analysis of 5 children with congentical thrombotic thrombocytopenia purpura showed complex heterozygous mutations at different loci of ADAMTS13 gene

  19. this study shows that in Upshaw-Schulman syndrome, age-onset defines two entities and ADAMTS13 sequence variations modify ADAMTS13 conformation

  20. acute myeloid leukemia patients with low activity of ADAMTS-13 had worse prognosis after bone morrow transplantation.

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) Interaktionspartner

  1. ADAMTS13 knockout promotes the occurrence of early brain injury after experimental subarachnoid hemorrhage.

  2. ADAMTS13-vWF axis is partially involved in the pathophysiology of kidney ischemic reperfusion injury.

  3. Adamts13 deficiency in obese mice promotes hepatic microthrombosis.

  4. results suggest that ADAMTS13 controls key steps of ischemic vascular remodeling and that recombinant ADAMTS13 is a putative therapeutic avenue for promoting stroke recovery.

  5. ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis.

  6. administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA patency and consequently reduced cerebral infarct sizes

  7. Sleeping beauty transposon-mediated gene therapy achieved sustained expression of transgene ADAMTS13 and long-term prophylaxis against congenital thrombotic thrombocytopenic purpura in Adamts13(-/-) mice.

  8. Results also suggest that Toxoplasma gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of toxoplasma encephalitis. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease.

  9. Letter: deficiency of ADAMTS13 results in increased formation of venous thrombosis in mice.

  10. ADAMTS13 substrate specificity

  11. Data indicate that the p.D187H mutation impairs ADAMTS13 activity and secretion and may contribute to thrombotic thrombocytopenic purpura.

  12. Data show that metalloendopeptidase ADAMTS13 does not directly promote development of adipose tissue.

  13. findings provide further evidence on the pathophysiological role for the ADAMTS13/VWF axis in atherosclerosis

  14. Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.

  15. Three novel mutations in a homozygous state were identified in these patients: c.1308G>C, c.428T>C (p.Ile143Thr) and c.1709A>G (p.Tyr570Cys)

  16. The results indicate that the microvascular process induced by ADAMTS13 deficiency triggers complement activation on platelets and the endothelium, which may contribute to formation of thrombotic microangiopathy.

  17. model of acute myocardial infarction in ADAMTS13 gene deleted (Adamts13 -/-) mice

  18. We hypothesize that ADAMTS13 protects brain from ischemia-reperfusion injury by regulating von Willebrand factor -dependent inflammation as well as microvascular plugging

  19. Cyclophilin B activity regulated secretion and activity of ADAMTS13.

  20. Adamts13(-/-) mice developed larger myocardial infarctions than wild-type control mice.

ADAMTS13 Antigen-Profil

Protein Überblick

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit ADAMTS13

  • ADAM metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13) Antikörper
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (Adamts13) Antikörper
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (adamts13) Antikörper
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (Adamts13) Antikörper
  • ADAM metallopeptidase with thrombospondin type 1 motif 13 (Adamts13) Antikörper
  • ADAM-TS13 Antikörper
  • ADAMTS-13 Antikörper
  • ADAMTS13 Antikörper
  • C9orf8 Antikörper
  • Gm710 Antikörper
  • vWF-CP Antikörper
  • VWFCP Antikörper

Bezeichner auf Proteinebene für ADAMTS13

ADAM metallopeptidase with thrombospondin type 1 motif, 13 , A disintegrin and metalloproteinase with thrombospondin motifs 13 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 , vWF-cleaving protease , von Willebrand factor-cleaving protease , ADAM-TS 13 , ADAM-TS13 , ADAMTS-13 , ADAMTS13 isoform IAP-b , vWF-CP mRNA for von Willebrand factor-cleaving , ADAM metallopeptidase with thrombospondin type 1 motif, 13 isoform 1 preproprotein-like , A disintegrin and metalloproteinase with thrombospondin motifs 13-like , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

GENE ID SPEZIES
100069281 Equus caballus
11093 Homo sapiens
279028 Mus musculus
532272 Bos taurus
100320289 Danio rerio
100404947 Callithrix jacchus
100343027 Oryctolagus cuniculus
100481099 Ailuropoda melanoleuca
100226372 Taeniopygia guttata
100630922 Canis lupus familiaris
102554393 Rattus norvegicus
100727045 Cavia porcellus
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