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DHCR24 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis.
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Human Polyclonal Seladin 1 Primary Antibody für WB - ABIN514969
Gilk, Cockrell, Luterbach, Hansen, Knodler, Ibarra, Steele-Mortimer, Heinzen: Bacterial colonization of host cells in the absence of cholesterol. in PLoS pathogens 2013
the expanding database of post-translational modifications will be a valuable resource for mapping the topology of membrane-associated proteins, such as DHCR24, that is, flagging cytosolic residues accessible to modifying enzymes such as kinases and ubiquitin ligases.
DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP (zeige AFP Antikörper)-negative hepatocellular carcinoma.
physical and functional interaction between DHCR24 and DHCR7 (zeige DHCR7 Antikörper)
In vitro experiments showed that DHCR24 overexpression induced tumor proliferation.
Data (including data from studies using RNA from post-mortem brain tissue) suggest that expression of DHCR24 is up-regulated in parietal cortex of patients with Huntington's disease as compared to control subjects.
Data indicate a mechanism whereby 3beta-hydroxysterol Delta24-reductase (DHCR24) activity is regulated by signaling.
DHCR24 expression protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum stress.
TR-beta (zeige TXNRD2 Antikörper) and LXR-alpha (zeige NR1H3 Antikörper) competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A.
DHCR24 gene expression is regulation by cholesterol availability.
a novel role for 24,25EC in cholesterol homeostasis, through its rapid inhibition of cholesterol synthesis at DHCR24.
When DHCR24 is genetically deleted there is a decreased association of EAAT2 (zeige SLC1A2 Antikörper) with lipid rafts after ischemia.
Data (including data from transgenic mice) suggest that expression of Dhcr24 is down-regulated in brain tissues of mice exhibiting symptoms modeling advanced Huntington's disease.
RE1-silencing transcription factor (zeige REST Antikörper) acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase
concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-alpha (zeige NR1H3 Antikörper) maintains the gene expression
This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
Seladin-1 is shown to be an LPS (zeige TLR4 Antikörper)-responsive gene that negatively regulates the TNF- alpha (zeige TNF Antikörper) production and bone resorption in response to LPS (zeige TLR4 Antikörper).
Seladin-1-dependent cholesterol synthesis is involved in lowering Abeta (zeige APP Antikörper) levels.
cellular cholesterol biosynthesis is critical for the activation and maintenance of the Akt (zeige AKT1 Antikörper)-Bad cell survival cascade in response to growth factors such as insulin (zeige INS Antikörper).
Cholesterol homeostasis in Dhcr24 knockout mice is characterized by strong activation of liver X receptor-targeted genes and by mechanisms compensating for cholesterol depletion.
ablation of DHCR24/seladin-1 prevented apoptosis of primary neurons in a p53 (zeige TP53 Antikörper)-dependent manner
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
, 3 beta-hydroxysterol delta 24-reductase
, 3-beta-hydroxysterol delta-24-reductase
, delta(24)-sterol reductase
, desmosterol-to-cholesterol enzyme
, diminuto/dwarf1 homolog
, seladin 1
, selective AD indicator 1
, 3-beta-hydroxysterol delta-24 reductase