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Hipk2 promotes PP1c-mediated Dvl (zeige DVL2 ELISA Kits) dephosphorylation via its C-terminal domain and is essential Dvl (zeige DVL2 ELISA Kits) stability.
Furthermore, our results suggest that modulation of either HIPK2 levels or activity could be exploited to impair NRF2 (zeige GABPA ELISA Kits)-mediated signalling in cancer cells, and thus sensitise them to chemotherapeutic drugs.
PARP1 (zeige PARP1 ELISA Kits) can modulate the tumor-suppressing function of HIPK2 by regulating the protein stability of HIPK2.
Data show that HIPK2-T566 phosphorylation contributes to UV-induced HIPK2 activity but it is dispensable for doxorubicin response.
In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7 (zeige FBXW7 ELISA Kits)-dependent proteasomal degradation of Notch1 (zeige NOTCH1 ELISA Kits) by phosphorylating its intracellular domain (Notch1 (zeige NOTCH1 ELISA Kits)-IC) within the Cdc4 (zeige FBXW7 ELISA Kits) phosphodegron motif.
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 (zeige HDAC5 ELISA Kits) or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5 (zeige HDAC5 ELISA Kits)-homeodomain-interacting protein kinase-2-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
These results suggest that the HIPK2-phospho-Ser271 CREB (zeige CREB1 ELISA Kits) axis is a new arsenic-responsive CREB (zeige CREB1 ELISA Kits) activation mechanism in parallel with the PKA-phospho-Ser133 CREB (zeige CREB1 ELISA Kits) axis.
Results demonstrated that HIPK2 may function as a novel regulator to modulate hepatic stellate cells activation, potentially by inhibiting the TGF-beta1 (zeige TGFB1 ELISA Kits)/Smad3 (zeige SMAD3 ELISA Kits) signaling pathway.
Data show strong reduction of cell viability was induced in vitro and in vivo by the homeodomain interacting protein kinase 2 exon 8 spliced isoform (Hipk2-Deltae8)-specific siRNA, supporting a potential therapeutic application.
Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.
Our findings indicate that phosphorylation-dependent restriction of SIRT1 (zeige SIRT1 ELISA Kits) activity by HIPK2 shapes the p53 (zeige TP53 ELISA Kits) response
reveal a previously unrecognized role of HIPK2 activation in ER-stress-mediated neurodegeneration and its potential role as a biomarker and therapeutic target for amyotrophic lateral sclerosis
HIPK2 is ubiquitinated upon heat shock.
Phosphorylation of KLF3 (zeige KLF3 ELISA Kits) and CtBP2 (zeige CTBP2 ELISA Kits) by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (zeige KLF3 ELISA Kits).
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator (zeige AIRE ELISA Kits) interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Hipk2 has an essential role in mouse white fat development
data identify Hipk2 as a novel regulator of C/EBPbeta (zeige CEBPB ELISA Kits) and implicate different protein kinases in the cooperation of p300 (zeige NOTCH1 ELISA Kits) with C/EBPbeta (zeige CEBPB ELISA Kits) and C/EBPalpha (zeige CEBPA ELISA Kits)
Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.
Hipk2 is a haploinsufficient tumor suppressor gene for mouse lymphoma development.
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene.
homeodomain interacting protein kinase 2
, serine/threonine protein kinase
, homeodomain-interacting protein kinase 2-like
, homeodomain-interacting protein kinase 2
, homeodomain-interacting protein kinase-2
, nuclear body-associated kinase 1
, sialophorin tail-associated nuclear serine/threonine-protein kinase
, Mx-interacting protein kinase PKM