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The opposing effects of ORC1 (zeige ORC1L ELISA Kits) (represor) and CDC6 (zeige CDC6 ELISA Kits) (gene activator) in controlling the level of Cyclin E ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment.
High cyclin E expression is associated with breast cancer.
High CCNC1 (zeige CNGA3 ELISA Kits) expression is associated with inflammatory breast cancer.
Inhibition of cell division cycle associated 2 (CDCA2 (zeige CDCA2 ELISA Kits)) suppressed the proliferation of lung adenocarcinoma (LAC (zeige LCT ELISA Kits)) cells via G1 phase arrest by downregulating cyclin E1(CCNE1), while overexpression of CDCA2 (zeige CDCA2 ELISA Kits) promoted LAC (zeige LCT ELISA Kits) cells proliferation by upregulating CCNE1.
a PI3K (zeige PIK3CA ELISA Kits)/PKCiota/cyclin E signaling pathway as a therapeutic target during ovarian tumorigenesis
Amplification of the G1-S regulatory genes, CCNE1, CCND1 and CdK6, represent an early event, which precedes ERBB2, EGFR, or KRAS amplification in gastric adenocarcinoma.
Amplification of 19q12 CCNE1/URI was found in 10.4% (28/270) and was significantly associated with type II endometrial cancer (EC) high grade, advanced FIGO stage, and aberrant tumor supressor p53 (zeige TP53 ELISA Kits) expression.
Data reveal that the presence of rs200996365, a SNP in high-linkage disequilibrium with rs8102137 residing in the center of a KLF5 (zeige KLF5 ELISA Kits) motif, alters KLF5 (zeige KLF5 ELISA Kits) binding to this genomic region and provide evidence that KLF5 (zeige KLF5 ELISA Kits) binds CCNE1 polymorphic intronic enhancer to confer increased bladder cancer risk.
Noxin (zeige C11orf82 ELISA Kits) facilitated the expression of Cyclin D1 (zeige CCND1 ELISA Kits) and Cyclin E1 through activating P38 (zeige CRK ELISA Kits)-activating transcription factor 2 (zeige ATF2 ELISA Kits) signaling pathway, thus enhanced cell growth of breast cancer
Results show that cyclin E1 and CDK2 (zeige CDK2 ELISA Kits) participate in STC1 (zeige STC1 ELISA Kits) promoting cell proliferation of prostate neoplasm cells.
These results demonstrate a repressor role for NFAT1 (zeige NFAT1 ELISA Kits) in cell cycle progression and Cyclin E expression in B lymphocytes, and suggest a potential function for NFAT1 (zeige NFAT1 ELISA Kits) protein in B cell malignancies.
This approach allowed us to determine the identity of cyclin E protein partners, as well as phosphorylation substrates of cyclins E (cyclin (zeige PCNA ELISA Kits) E1and cyclin E2 (zeige CCNE2 ELISA Kits))and its associated kinase, Cdk2 (zeige CDK2 ELISA Kits), in different mouse organs.
inhibition of PDK4 (zeige PDK4 ELISA Kits) activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2 (zeige CCNA2 ELISA Kits), and E2F1 (zeige E2F1 ELISA Kits) proteins.
Spermatocytes lacking cyclin E2 (zeige CCNE2 ELISA Kits) and one E1 allele (E1+/-E2-/-) displayed a high rate of telomere abnormalities but can progress to pachytene and diplotene stages.
NF-kappaB (zeige NFKB1 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-195/497-Igf1r (zeige IGF1R ELISA Kits)/Insr (zeige INSR ELISA Kits)-Ccnd2 (zeige CCND2 ELISA Kits)/Ccne1 plays important roles in myogenesis.
Myb (zeige MYB ELISA Kits) regulates Cyclin E1 expression in normal gastrointestinal tract epithelial cells and is required during intestinal tumorigenesis
These results highlight a new role for E-type cyclins (Ccne1 and Ccne2 (zeige CCNE2 ELISA Kits)) as important regulators of male meiosis.
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 (zeige CDK2 ELISA Kits) in hepatocytes inhibits DNA replication and liver regeneration in mice.
Superoxide dismutase (zeige SOD1 ELISA Kits) induces G1-phase cell cycle arrest by down-regulated expression of Cdk-2 (zeige CDK2 ELISA Kits) and cyclin-E in sarcoma tumor cells.
Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation.
miR (zeige MYLIP ELISA Kits)-15/16 and CPEB co-regulate cyclin E1 mRNA.
cyclin E is dynamically and highly conjugated to SUMO2 (zeige SUMO2 ELISA Kits)/3 on chromatin, independently of Cdk2 (zeige CDK2 ELISA Kits) activity and origin activation.
These results show that cyclin E destruction at the midblastula transition requires both phosphorylation and nuclear import, as well as proteasomal activity.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 ELISA Kits), wee1 (zeige WEE1 ELISA Kits), p21 (zeige CDKN1A ELISA Kits), PCNA (zeige PCNA ELISA Kits) and cdk2 (zeige CDK2 ELISA Kits), but only weakly influences cyclin B1 (zeige CCNB1 ELISA Kits), cyclin B2 (zeige CCNB2 ELISA Kits) and cyclin E1 expression.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
, G1/S-specific cyclin-E1
, G1/S-specific cyclin-E1-like
, g1/S-specific cyclin-E1-like
, cyclin Es
, cyclin Et
, cyclin E
, G1/S-specific cyclin-E2
, G1/S-specific cyclin-E3
, cyclin E3