anti-BRCA1 (BRCA1) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 583 Breast Cancer 1 (BRCA1) Antikörper von 33 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen BRCA1 Kits (33) und BRCA1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 641 BRCA1 Produkte verfügbar.
Synonyme:
BRCA1, brcai, brcc1, BROVCA1, iris, LOC100224649, PNCA4, PPP1R53, pscp, rnf53
Alle Antikörper anzeigen Gen GeneID UniProt
BRCA1 672 P38398
BRCA1 12189 P48754
BRCA1 497672 O54952

Meistgesuchte Reaktivitäten zu anti-BRCA1 (BRCA1) Antikörper

anti-Human BRCA1 Antikörper:

anti-Mouse (Murine) BRCA1 Antikörper:

anti-Rat (Rattus) BRCA1 Antikörper:

Alle verfügbaren anti-BRCA1 Antikörper

Sie gelangen zu unserer vorgefilterten Suche.

Weitere Antikörper gegen BRCA1 Interaktionspartner

Mouse (Murine) Breast Cancer 1 (BRCA1) Interaktionspartner

  1. Genomic instability can be rescued by deletion of Trp53bp1 (zeige TP53BP1 Antikörper), encoding the DNA damage response factor 53BP1 (zeige TP53BP1 Antikörper); mice expressing RING-less BRCA1 do not show an increased susceptibility to tumors in the absence of 53BP1 (zeige TP53BP1 Antikörper); Genomic instability in cells expressing RING-less BRCA1 correlates with loss of BARD1 (zeige BARD1 Antikörper) and a defect in restart of replication forks after hydroxyurea treatment

  2. the aberrant proliferative capacity of Brca1(-/-) luminal progenitor cells is linked to the replication-associated DNA damage response, where proliferation of mammary progenitors is perpetuated by damage-induced, autologous NF-kappaB (zeige NFKB1 Antikörper) signaling.

  3. We report here elevated recombination rates at telomeres in cells from human BRCA1 mutation carriers and in mouse embryonic stem cells lacking both copies of functional Brca1.

  4. loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 (zeige CDKN2A Antikörper) and a decline of stem cell function, which was rescued by p16 (zeige CDKN2A Antikörper) loss.

  5. Brca1-Wwox (zeige WWOX Antikörper) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (zeige WWOX Antikörper)-sufficient cells

  6. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  7. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  8. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (zeige COBRA1 Antikörper)-dependent transcription program during mammary gland development.

  9. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  10. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

Human Breast Cancer 1 (BRCA1) Interaktionspartner

  1. These results reveal a synthetic lethal relationship between FANCD2 and BRCA1/2.

  2. This study implicates novel risk loci as well as highlights the clinical utility for retesting BRCA1/2 negative ovarian cancer patients by genomic sequencing and analysis of genes in relevant pathways.

  3. Women with BRCA1/2 mutations show at diagnosis higher peritoneal tumor load and increased frequency of bulky lymph nodes compared to patients without germline BRCA mutations. Primary debulking surgery seems to ensure a longer progression-free survival in women with BRCA wild type genotype compared to neoadjuvant chemotherapy.

  4. Using electrophoretic retardation assay, atomic force microscopy and DNA binding competition assay, the study showed the greatest preference of the BRCA1 DNA-binding domain to cruciform structure, followed by DNA quadruplex, with the weakest affinity to double stranded B-DNA and single stranded DNA.

  5. Sixteen VUS from 51 BRCA1 variants of uncertain significance (VUS) carriers and 28 VUS from 62 BRCA2 (zeige BRCA2 Antikörper) VUS carriers were analyzed. There was a slight agreement between the two analyses, with a kappa value of 0.14 (95% confidence interval (CI) = -0.34 to 0.62) for the BRCA1 VUS and a kappa value of 0.17 (95% CI = -0.10 to 0.49) for the BRCA2 (zeige BRCA2 Antikörper) VUS

  6. Study showed that the prevalence of BRCA1/2 germline mutations was 19% in epithelial ovarian cancer, mostly detected in different gene locations. Two novel frameshift mutations were identified, one in BRCA1 and one in BRCA2 (zeige BRCA2 Antikörper), as well as two large deletions.

  7. This study shows that BRCA mutation carriers could be frequently identified among breast cancer patients with multiple risk factors. Importantly, we established an NGS-based pipeline for BRCA1/2 testing in clinical practice and strongly suggest that breast cancer patients of premier- and moderate-grade risks receive BRCA1/2 mutations testing in China

  8. Studies suggest that people with high risk of breast cancer and negative BRCA1/BRCA2 (zeige BRCA2 Antikörper) should be tested for PALB2 (zeige PALB2 Antikörper) mutations.

  9. Even if a BRCA1 mutation is already identified within a family, the presence of early onset breast cancer affected non-carriers hampers accurate risk estimates for both mutation carriers and other negative family members.

  10. polygenic risk scores may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management.

Cow (Bovine) Breast Cancer 1 (BRCA1) Interaktionspartner

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) Interaktionspartner

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 Antigen-Profil

Beschreibung des Gens

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1, early onset (BRCA1) Antikörper
  • breast cancer 1, early onset (brca1) Antikörper
  • breast cancer 1, early onset (LOC100224649) Antikörper
  • breast cancer 1, early onset (LOC100347269) Antikörper
  • breast cancer 1 (Brca1) Antikörper
  • breast cancer 1, early onset (Brca1) Antikörper
  • BRCA1 Antikörper
  • brcai Antikörper
  • brcc1 Antikörper
  • BROVCA1 Antikörper
  • iris Antikörper
  • LOC100224649 Antikörper
  • PNCA4 Antikörper
  • PPP1R53 Antikörper
  • pscp Antikörper
  • rnf53 Antikörper

Bezeichner auf Proteinebene für BRCA1

BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , breast cancer type 1 susceptibility protein homolog , breast cancer 1, early onset , BRCA1 homolog , breast and ovarian cancer susceptibility protein , breast cancer associated 1

GENE ID SPEZIES
672 Homo sapiens
353120 Bos taurus
373983 Gallus gallus
403437 Canis lupus familiaris
449497 Pan troglodytes
554178 Monodelphis domestica
712634 Macaca mulatta
733513 Xenopus (Silurana) tropicalis
755086 Strongylocentrotus purpuratus
100049662 Sus scrofa
100051990 Equus caballus
100224649 Taeniopygia guttata
100347269 Oryctolagus cuniculus
12189 Mus musculus
497672 Rattus norvegicus
493761 Felis catus
399391 Xenopus laevis
Ausgewählte Anbieter für anti-BRCA1 (BRCA1) Antikörper
Haben Sie etwas anderes gesucht?