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Caudal Wnt8a is expressed only early somite stages. It is needed for normal anterior trunk development in the absence of Wnt3a (zeige WNT3A Proteine). Wnt8a and Wnt3a (zeige WNT3A Proteine) cooperate to maintain Fgf8 (zeige FGF8 Proteine) expression and stop premature Sox2 (zeige SOX2 Proteine) up-regulation in the axial stem cell niche.
Wnt8a expression depends on the presence of Fgf3 (zeige FGF3 Proteine) indicating a serial regulation between Fgf and Wnt (zeige WNT2 Proteine) signalling during otic placode induction and specification.
demonstrate that both the enlargement of the otic placode and the expansion of the Wnt8a expression domain can be rescued in Spry1 (zeige SPRY1 Proteine)/; Spry2 (zeige SPRY2 Proteine)/ embryos by reducing the gene dosage of Fgf10 (zeige FGF10 Proteine)
FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
The Wnt8A expression was evaluted in the resultant Tg(CAG-mWnt8A) embryos to identify mWnt8A misexpression.
the WNT8A gene is involved in the susceptibility to HSCR (zeige EDNRB Proteine), and plays an important role in the occurrence and development of Hirschsprung's disease.
Expression and regulation of WNT8A mRNA in human tumor cell lines
Data suggest that Wnt3 (zeige WNT3A Proteine), Wnt3a (zeige WNT3A Proteine), and Wnt8a bind to their respective receptors (Fz8 (zeige FZD2 Proteine), Lrp6 (zeige LRP5 Proteine), and Lypd6 (zeige LYPD6 Proteine)) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt (zeige WNT2 Proteine) proteins to their receptor complexes and stimulation of downstream signaling activity.
Wnt8, in addition to its well-established role in posterior mesoderm patterning, also plays a later role as a factor that expands the renal progenitor pool prior to kidney morphogenesis.
Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl (zeige DAZL Proteine), in the zebrafish embryo have been presented.
Gain of function of Wnt8a results in the accumulation of beta-catenin (zeige CTNNB1 Proteine) into the nuclei of all cells of the gastrula from the margin to the animal pole.
A filopodia-based transport system for Wnt8a controls anteroposterior patterning of the neural plate during vertebrate gastrulation.
Wnt (zeige WNT2 Proteine) limits its own signaling activity in part via up-regulation of a transporter, slc35c1 that promotes terminal fucosylation and thereby limits Wnt (zeige WNT2 Proteine) activity.
Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm.
post-transcriptional control of wnt8a is essential to fine tune the balance of the signaling outputs of the complex wnt8a locus, which is essential to zebrafish axis development
A novel role for Eaf1 (zeige EAF1 Proteine) and Eaf2 (zeige EAF2 Proteine) in inhibiting canonical Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling, which might form the mechanistic basis for Eaf1 (zeige EAF1 Proteine) and Eaf2 (zeige EAF2 Proteine) tumor suppressor activity.
Wnt8a expression pattern reflects complex interactions of multiple regulatory inputs.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid identity to the mouse Wnt8A protein.
wingless-type MMTV integration site family, member 8A
, protein Wnt-8a
, protein Wnt-8a-like
, protein Wnt-8d
, stimulated by retinoic acid gene 11 protein
, wingless-related MMTV integration site 8D
, wingless-related MMTV integration site 8A
, protein Wnt-8a ORF1
, protein Wnt-8c