anti-Maus TLE4 Antikörper für Enzyme Immunoassay

Recommended TLE4 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila) (TLE4) Antikörper
  • TLE4
  • NV17443
  • BCE-1
  • BCE1
  • E(spI)
  • ESG
  • ESG4
  • GRG4
  • Esp2
  • Grg4
  • XGrg-4
  • XTCF-4
  • Xgrg4
  • Xtle4
  • esg4
  • grg4
  • gro
  • 5730411M05Rik
  • AA792082
  • Bce-1
  • Bce1
  • ESTM13
  • ESTM14
  • X83332
  • X83333
  • transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
  • transducin-like enhancer of split 4 (E(sp1) homolog)
  • transducin-like enhancer of split 4, homolog of Drosophila E(spl)
  • TLE4
  • LOC100229224
  • Tle4
  • tle4
Reaktivität
Human, Maus, Ratte (Rattus)
82
40
39
6
3
2
2
2
2
2
1
1
1
1
Wirt
Kaninchen
65
17
Klonalität
Polyklonal
Konjugat
Dieser TLE4 Antikörper ist unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
66
34
14
13
11
5
2
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN272213
$ 390.50
Zzgl. Versandkosten $45.00

General

Antigen Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila) (TLE4) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(82), (40), (39), (6), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(65), (17)
Klonalität
Polyklonal
Konjugat Dieser TLE4 Antikörper ist unkonjugiert
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Western Blotting (WB)
(66), (34), (14), (13), (11), (5), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TLE4 Antikörper

Target Details TLE4 Anwendungsinformationen Handhabung Bilder
Spezifität This antibody detects endogenous levels of TLE4 protein. (region surrounding His190)
Kreuzreaktivität (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Reinigung The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Reinheit > 95 % pure by SDS-PAGE

Target Details TLE4

Produktdetails anti-TLE4 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung TLE4 (TLE4 Antibody Abstract)
Hintergrund The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is up-regulated, and TLE2 and TLE4 are down-regulated.Synonyms: GRG4, Groucho-related protein 4, KIAA1261, Transducin-like enhancer protein 4
Molekulargewicht approx. 83 kDa
Gen-ID 7091
NCBI Accession NP_008936
UniProt Q04727
Forschungsgebiet Chromatin and Nuclear Signaling, Transcription Factors, Wnt, Wnt Signaling
Pathways WNT Signalweg

Anwendungsinformationen

Produktdetails anti-TLE4 Antikörper Target Details TLE4 Handhabung Bilder zurück nach oben
Applikationshinweise ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLE4 Antikörper Target Details TLE4 Anwendungsinformationen Bilder zurück nach oben
Konzentration 1,0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung DO NOT FREEZE!
Lagerung 4 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C.

Bilder

Produktdetails anti-TLE4 Antikörper Target Details TLE4 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
 image for anti-Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila) (TLE4) antibody (ABIN272213) anti-Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila) (TLE4) antibody