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apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (zeige CDK2 ELISA Kits), leading to shortening of G1 and S phases
Neural induction by Syn4 (zeige SNTG1 ELISA Kits) through the PKC (zeige PKC ELISA Kits) pathway requires inhibition of PKCdelta (zeige PKCd ELISA Kits) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (zeige PKC ELISA Kits) of the KCNE1 (zeige KCNE1 ELISA Kits) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (zeige PKC ELISA Kits) in Kv4.3 (zeige KCND3 ELISA Kits)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
Data suggest that phosphorylation activity of PRKCA stems from conformational flexibility in region C-terminal to phosphorylated Ser (zeige SIGLEC1 ELISA Kits)/Thr (zeige TRH ELISA Kits) residues; flexibility of substrate-kinase interaction enables an Arg/Lys (zeige LYZ ELISA Kits) two to three amino acids C-terminal to phosphorylated Ser (zeige SIGLEC1 ELISA Kits)/Thr (zeige TRH ELISA Kits) to prime a catalytically active conformation, facilitating phosphoryl transfer to substrate.
these results provide evidence for inherent deficits in the cystic fibrosis (zeige S100A8 ELISA Kits) macrophage oxidative burst caused by decreased phosphorylation of NADPH oxidase (zeige NOX1 ELISA Kits) cytosolic components that are augmented by Burkholderia
The interplay between intracellular progesterone receptor (zeige PGR ELISA Kits) and PRKCA-PRKCD (zeige PKCd ELISA Kits) plays a key role in migration and invasion of human glioblastoma cells.
PRKCA SNPs are associated with neuropathic pain post total joint replacement.
These findings provide the first evidence linking PKC activation to suppression of Kv7 currents, membrane depolarization, and Ca(2 (zeige CA2 ELISA Kits)+) influx via L (zeige COX6A1 ELISA Kits)-type voltage-sensitive Ca(2 (zeige CA2 ELISA Kits)+) channels as a mechanism for histamine-induced bronchoconstriction.
In polymorphism PRKCA rs9892651, HDL (zeige HSD11B1 ELISA Kits)-C levels were lower in carriers of CC and TC genotypes that were more frequent in current-wheezers Vs TT genotype (52.2 and 52.7 Vs 55.2 mg/dl, p-value = 0.042 and p-value for trend = 0.02).
Ca(2+)-PKC-MARCKS-PIP2-PI3K-PIP3 system functions as an activation module in vitro
phosphorylation of TIMAP on Ser331 by PKC represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM dephosphorylation
PKCalpha-GSK3beta (zeige GSK3b ELISA Kits)-NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathway involvement in TRAIL-induced apoptosis
Curcumin inhibited phorbol ester-induced membrane translocation of protein kinase C-epsilon (PKCepsilon (zeige PRKCE ELISA Kits)) mutants, in which the epsilonC1 domain was replaced with alphaC1, but not the protein kinase C-alpha (PKCalpha) mutant in which alphaC1 was replaced with the epsilonC1 domain, suggesting that alphaC1 is a determinant for curcumin's inhibitory effect.
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (zeige SYT1 ELISA Kits) phosphorylation is an essential step in PKC (zeige PKC ELISA Kits)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (zeige PKC ELISA Kits) substrates, Munc13-1 (zeige UNC13A ELISA Kits) and Munc18-1 (zeige STXBP1 ELISA Kits).
These data indicate that LPA increases CCN2 (zeige CTGF ELISA Kits) expression through the activation of PKC (zeige PKC ELISA Kits) and PKA. Thus, the regulatory functions of the PKC (zeige PKC ELISA Kits) and PKA pathways are implicated in the LPA-induced increase in CCN2 (zeige CTGF ELISA Kits) expression
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
We conclude that melatonin, via modulation of PKC (zeige PKC ELISA Kits) and Ca(2 (zeige CA2 ELISA Kits)+) signaling, could potentially stimulate the Nrf2 (zeige NFE2L2 ELISA Kits)-mediated antioxidant response in mouse pancreatic acinar cells.
PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (zeige TBXA2R ELISA Kits), possibly via increased pulmonary arterial TP receptor (zeige TBXA2R ELISA Kits) expression.
at the functionally mature calyx of Held synapse the Ca(2 (zeige CA2 ELISA Kits)+)-dependent protein kinase C (zeige PKC ELISA Kits) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
PKC gene deletion is responsible for hair loss.
PKC (zeige PKC ELISA Kits) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (zeige GRM5 ELISA Kits) and AMPA (zeige GRIA3 ELISA Kits)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (zeige CA2 ELISA Kits)+-sensitivity, structure and kinetics are brought about through PKC (zeige PKC ELISA Kits) phosphorylation of cardiac troponin T (zeige TNNT2 ELISA Kits).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 ELISA Kits) expression by NF-kappaB (zeige NFKB1 ELISA Kits)-MT1-MMP (zeige MMP14 ELISA Kits)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (zeige ASS1 ELISA Kits) Ser (zeige SIGLEC1 ELISA Kits)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (zeige TUBB ELISA Kits).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (zeige Akap6 ELISA Kits)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (zeige CDK7 ELISA Kits) Calpha (zeige PRKACA ELISA Kits)
By regulating VEGFR2 (zeige KDR ELISA Kits) expression and activation, PKC-epsilon (zeige PRKCE ELISA Kits) expression is critical for activation of Akt (zeige AKT1 ELISA Kits) and eNOS (zeige NOS3 ELISA Kits) by VEGF (zeige VEGFA ELISA Kits) and contributes to VEGF (zeige VEGFA ELISA Kits)-stimulated Erk (zeige MAPK1 ELISA Kits) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (zeige CA2 ELISA Kits)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (zeige PPP1R14A ELISA Kits) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (zeige ESR1 ELISA Kits).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha