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Alternative splicing generates several isoforms of zneo1, most of which are developmentally regulated, showing distinct distribution in brain and other tissues
The results indicate that RGMB (zeige RGMB ELISA Kits)-neogenin-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the developing olfactory epithelium.
Thus, our findings identify an unrecognized function of neogenin in mouse neocortical astrocyte differentiation, and suggest a signaling pathway, BMP2 (zeige BMP2 ELISA Kits)-neogenin-YAP (zeige YAP1 ELISA Kits)-Smad1 (zeige SMAD1 ELISA Kits), underlying astrogliogenesis in developing mouse neocortex.
Results indicate that an efficient induction of hepcidin (zeige HAMP ELISA Kits) expression by hemojuvelin (HJV (zeige HFE2 ELISA Kits)) requires its interaction with neogenin.
Neogenin acts to synchronize neuroblast migration and terminal differentiation through the regulation of neuroblast cell cycle kinetics within the neurogenic microenvironment of the RMS.
these results highlight Neogenin1 as a novel downstream effector of the Sonic Hedgehog (zeige SHH ELISA Kits) pathway in medulloblastoma
Strong expression of RGMa (zeige RGMA ELISA Kits), RGMb (zeige RGMB ELISA Kits) and Neogenin protein was found on several major axon tracts such as the primary olfactory projections, anterior commissure and fasciculus retroflexus.
neogenin appears to suppress Myo (zeige SYNPO2 ELISA Kits) X movement on the basal side, but increases its movement towards the apical and dorsal side of a cell, promoting dorsal filopodium formation and growth
guidance receptor neogenin holds crucial importance for the propagation of an acute inflammatory response and further define mechanisms shared between the nervous and the immune system.
identification of neogenin-binding site on the repulsive guidance molecule A (zeige RGMA ELISA Kits)
these findings indicate that neogenin regulates SHH (zeige SHH ELISA Kits) signaling in the limb bud to achieve proper digit patterning.
Environmental and endogenous proteases may contribute to cancer development by depleting DCC (zeige DCC ELISA Kits) and neogenin.
these results suggested that GD3 recruits gamma-secretase to lipid/rafts, allowing efficient cleavage of neogenin.
The hemizygous 15q deletion unmasks the recessive functional polymorphism in NEO1 which plays a pivotal role in cortical interneuron development; study provides the first evidence linking NEO1 with autism spectrum disorders in humans
Neogenin influences both cadherin dynamics and junctional tension.
Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways
The present study demonstrates that neogenin may be a tumor suppressor in breast cancer. Neogenin may serve as a potential diagnostic marker and therapeutic target for breast cancer.
These results show how repulsive guidance molecule acts as the central hub that links BMP2 (zeige BMP2 ELISA Kits) and NEO1 and physically connects these fundamental signaling pathways.
Neogenin expression is inversely associated with breast cancer grade.
high-expression of neogenin-1 promotes gastric cancer proliferation and motility
miR (zeige MLXIP ELISA Kits)-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin.
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants.
, neogenin 1
, neogenin homolog 1
, immunoglobulin superfamily DCC subclass member 2