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Human MFI2 ELISA Kit für Sandwich ELISA - ABIN417704
Duś-Szachniewicz, Ostasiewicz, Woźniak, Kołodziej, Wiśniewski, Ziółkowski: Pattern of Melanotransferrin Expression in Human Colorectal Tissues: An Immunohistochemical Study on Potential Clinical Application. in Anticancer research 2015
functional dissection of MTf in epithelial junction assembly and morphogenesis
Melanotransferrin is a serological marker of colorectal cancer by secretome analysis and quantitative proteomics.
PC3 (zeige PCSK1 ELISA Kits) tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low.
The human genome contains a second melanotransferrin gene (MTf2). There are two isoforms of melanotransferrin.
its ability to donate 59Fe to SK-Mel (zeige RAB8A ELISA Kits)-28 melanoma cells and other cell types
This melanoma-associated (zeige ZNF654 ELISA Kits) marker was detected in melanoma cell lines.
membrane-bound and soluble p97 (zeige EIF4G2 ELISA Kits) affect the migration capacity of endothelial and melanoma cells and suggest that p97 (zeige EIF4G2 ELISA Kits) could be involved in the regulation of plasminogen (zeige PLG ELISA Kits) activation by interacting with pro-uPA (zeige PRAP1 ELISA Kits) and plasminogen (zeige PLG ELISA Kits).
Serum melanotransferrin exists in various conformations depending on the binding of bivalent cations or following post-translational modification; serum melanotransferrin levels are unchanged in subjects with Alzheimer's disease.
The distribution of MTf and its splice variants may provide clues to their possible biological roles in melanoma and other tumors.
melanotransferrin has a role in cell proliferation and tumorigenesis
Anti-angiogenic properties of soluble melanotransferrin may result from local overstimulation of plasminogen (zeige PLG ELISA Kits) activation by tissue plasminogen activator (zeige PLAT ELISA Kits), thus leading to subsequent degradation of the fibronectin (zeige FN1 ELISA Kits) matrix and endothelial cell detachment.
MTf represents the first identification of a plant lectin receptor involved in cell-shape changes and the differentiation of animal cells
Iron indices, tissue levels, hematology, and serum chemistry parameters demonstrated no differences between metallototransferrin deficient and wild-type mice, suggesting MTf was not essential for iron metabolism.
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.
, melanoma-associated antigen p97
, membrane-bound transferrin-like protein
, membrane-bound transferrin-like protein p97