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Inhibition of HDAC3 (zeige HDAC3 ELISA Kits) with targeted therapy could benefit treatment of the diseases associated with sGCbeta1 down-regulation and/or deficiency such as cancer and several vascular-related diseases.
The kinetics of heme loss from oxidized sGC (zeige SGCB ELISA Kits) was monitored by a new method based on the heme group de-quenching the fluorescence of FlAsH-EDT2.
Dynamic interplay between hsp90 (zeige HSP90 ELISA Kits), apo (zeige C9orf3 ELISA Kits)-sGC (zeige SGCB ELISA Kits)-beta1, and sGC (zeige SGCB ELISA Kits)-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC (zeige SGCB ELISA Kits) for signaling cascades.
Gene expression in dendritic cells of CCL5 (zeige CCL5 ELISA Kits) and CXCL5 (zeige CXCL5 ELISA Kits) as well as TIMP1 (zeige TIMP1 ELISA Kits) and GUCY1B3 showed a significant increase within the first 4 days after trauma.
The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase
We concluded that the alpha-subunit (zeige POLG ELISA Kits) and the beta(1)(191-619) domain exert structural strains on the heme domain.
Data show that show that it is possible to directly monitor the sGC (zeige SGCB ELISA Kits) haem oxidation state in intact cells. By inserting the TC motif into the coding sequence of the beta1 subunit of sGC (zeige SGCB ELISA Kits) in transiently transfected Chinese hamster ovary cells.
recombinant soluble guanylate cyclase (sGC (zeige SGCB ELISA Kits)) beta1 subunit and truncated N-terminal fragments expressed in E. coli; studied interaction between NO and sGC (zeige SGCB ELISA Kits) and schematic mechanism was proposed; study provides insights into structure and NO-binding of sGC (zeige SGCB ELISA Kits)
Results show that NOGCbeta1 and GC-A (zeige NPR1 ELISA Kits) interact and that NOGCbeta1 regulates atrial natriuretic peptide (zeige NPPA ELISA Kits) signaling in HK-2 (zeige HK2 ELISA Kits) cells.
Although soluble guanylate cyclase(sGC (zeige SGCB ELISA Kits)) beta1-subunit expression was increased in mononuclear cells from patients with erectile dysfunction, the sGC (zeige SGCB ELISA Kits) activity was reduced
expression of sGC (zeige NPR1 ELISA Kits) beta(1)-subunit in pulmonary arteries increased with postnatal age both at the level of mRNA and protein
These results suggest a means by which the hsp90beta (zeige HSP90AB1 ELISA Kits) interaction could prevent apo (zeige C9orf3 ELISA Kits)-sGCbeta1 from associating with its partner sGCalpha1 subunit while enabling structural changes to assist heme insertion into the H-NOX domain.
Apo (zeige C9orf3 ELISA Kits)-sGC (zeige NPR1 ELISA Kits) mice expressing haem-free sGC (zeige NPR1 ELISA Kits) are viable and develop hypertension. The haemodynamic effects of NO are abolished, but those of the sGC (zeige NPR1 ELISA Kits) activator cinaciguat are enhanced.
sGC (zeige NPR1 ELISA Kits) and cGMP-dependent signaling are necessary and sufficient for HNO-induced vasodilation in vivo but are not required for positive inotropic action.
Deletion of GCbeta1 specifically in smooth muscle cells abolishes NO-induced corpus cavernosum relaxation but does not lead to infertility.
A VASP (zeige VASP ELISA Kits) to Rac (zeige AKT1 ELISA Kits) to soluble guanylyl cyclase negative feedback loop limited cGMP production, thereby regulating adipogenesis and energy homeostasis.
These data suggests a novel physiological role for PDE5 (zeige PDE5A ELISA Kits) in restricting the effects of NOS3 (zeige NOS3 ELISA Kits)/sGC (zeige NPR1 ELISA Kits)/PKG (zeige PRKG1 ELISA Kits) signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC (zeige NPR1 ELISA Kits)]
Pressure overload results in translocation of sGC (zeige NPR1 ELISA Kits) out of membrane microdomains, depressing NO/heme-dependent activation in the heart, consistent with enhanced oxidation.
Important roles of sGC (zeige NPR1 ELISA Kits) in stimulating platelet activation and in vivo thrombosis and hemostasis.
findings identify a crucial role of the NO/sGCalpha1beta1/cGMP pathway in modulating lymphatic vessel function [soluble guanylate cyclase alpha1beta1]
Knockout of GCbeta1 completely disrupts the NO/cGMP signaling cascade and provides evidence for the unique role of NO-GC as NO receptor.
cGMP generated by sGC (zeige NPR1 ELISA Kits)(alpha)(1)beta(1) protects against cardiac dysfunction and mortality in murine inflammatory shock models
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998
guanylate cyclase 1, soluble, beta 3
, guanylate cyclase soluble subunit beta-1-like
, guanylate cyclase soluble subunit beta-1
, soluble guanylyl cyclase beta subunit
, guanylate cyclase soluble subunit beta-3
, soluble guanylate cyclase small subunit
, soluble guanylate cyclase 1 beta 3
, soluble guanylyl cyclase beta 1 subunit
, NO-sensitive GC beta 1 subunit
, nitric oxide-sensitive guanylyl cyclase beta 1 subunit
, NO-sensitive guanylyl cyclase beta 1 subunit
, beta 1 sGC
, soluble guanylate cyclase beta-1 subunit
, guanylate cyclase, soluble, beta 1