TLR4 Proteine (TLR4)

Bezeichnung:
Toll-Like Receptor 4 Proteine (TLR4)
Auf www.antikoerper-online.de finden Sie aktuell 21 Toll-Like Receptor 4 (TLR4) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TLR4 Antikörper (613) und TLR4 Kits (58) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 707 TLR4 Produkte verfügbar.
Synonyme:
ARMD10, CD284, Lps, Ly87, Ran/M1, Rasl2-8, TLR-4, TOLL
alle Proteine anzeigen Gen GeneID UniProt
TLR4 7099 O00206
TLR4 21898 Q9QUK6
TLR4 29260 Q9QX05

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Am meisten referenzierte TLR4 Proteine

  1. Human TLR4 Protein expressed in Wheat germ - ABIN1322876 : Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008 (PubMed)
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Weitere Proteine zu TLR4 Interaktionspartnern

Human Toll-Like Receptor 4 (TLR4) Interaktionspartner

  1. Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS(-/-) and TLR4(-/-) cells.

  2. Here the authors show that MAL (zeige MAL Proteine) TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 TIR domains and induce formation of MyD88 (zeige MYD88 Proteine) assemblies.

  3. Experiments demonstrate for the first time that palmitic acid activation of TLR4 occurs in response to direct molecular interactions between palmitic acid and MD-2 (zeige LY96 Proteine); suggest a likely molecular mechanism for palmitic acid induction of pro-inflammatory immune responses in human dendritic cells expressing TLR4.

  4. In LPS-stimulated HEK293 cells with low CD14 and high (zeige IRF6 Proteine) TLR4, no accumulation of PI(4,5)P2 occurred. With an increasing amount of CD14 and decrease of TLR4, 2 peaks of PI(4,5)P2 appeared, approaching those found in LPS-stimulated cells expressing CD14 alone. This suggests that LPS-induced accumulation of PI(4,5)P2 that maximizes TLR4 signaling is controlled by CD14, whereas TLR4 can fine tune this via PI(4,5)P2 turnover.

  5. TLR4 coding SNPs Asp299Gly and Thr399Ile might be used as genetic susceptibility alleles for POAG

  6. Estradiol alters the immune-responsiveness of cultured HECECs to TLR2 and TLR4 ligands in a complex fashion that appears to vary with bacterial ligand, TLR subtype, and duration of exposure

  7. Ligand-driven triggering of TLR-3 (zeige TLR3 Proteine), -4, NOD2, and DC-SIGN (zeige CD209 Proteine), despite reducing viral replication, markedly increased the capacity of infected dendritic cells to stimulate HIV-specific cytotoxic T-cells.

  8. The study demonstrated that HIV infection sensitizes Kupffer cells to the proinflammatory effects of lipopolysaccharides in a TLR4-dependent manner.

  9. The lipid flippases, ATP8B1 (zeige ATP8B1 Proteine) and ATP11A (zeige ATP11A Proteine) are novel elements of the innate immune response that are essential to attenuate the inflammatory response, possibly by mediating endotoxin-induced internalization of TLR4.

  10. these findings identify new compounds for antagonizing TLR2 and TLR4 activation and define structural properties of POPG analogs for discriminating between two TLR systems.

Mouse (Murine) Toll-Like Receptor 4 (TLR4) Interaktionspartner

  1. Stimulation of the TLR4-TRIF (zeige RNF138 Proteine) pathway can protect against the development of allergic airway disease and that a TRIF (zeige RNF138 Proteine)-dependent adjuvant effect on CD4 (zeige CD4 Proteine)(+) ICOS (zeige ICOS Proteine)(+) T-cell responses may be a contributing mechanism.

  2. HMGB1 (zeige HMGB1 Proteine) activates the NF-kappaB (zeige NFKB1 Proteine) and JNK (zeige MAPK8 Proteine)/p38 (zeige CRK Proteine) pathways through TLR4/MyD88 (zeige MYD88 Proteine)-dependent signaling and induces an inflammatory response in lungs exposed to cigarette smoke.

  3. Findings reveal that TLR4 mutant significantly abated the intestinal IR injury and ALI at least in part by alleviating the inflammatory response and oxidative stress.

  4. These findings indicate that TLR2 and TLR4 are required to control Brucella microti infection in mice and that this effect could be related to its participation in the maturation of dendritic cells and the generation of specific CD8 (zeige CD8A Proteine)(+) Tc cells.

  5. Monophosphoryl lipid A stimulation of a TLR4-TRIF (zeige RNF138 Proteine)-PI3K-Akt (zeige AKT1 Proteine) pathway prevents lipopolysaccharide-induced ERK (zeige EPHB2 Proteine) activation in the medullar thick ascending limb.

  6. Results show that TLR4 plays a critical role in the effects of dietary fat composition on the development of hepatic steatosis, inflammation, and injury consistent with nonalcoholic steatohepatitis.

  7. FasL (zeige FASL Proteine) expression in splenic CD5 (zeige CD5 Proteine)(+)CD1d (zeige CD1D Proteine)(hi) B cells was decreased compared to the control group after TLR4 ligation.

  8. Stimulation of murine peritoneal macrophages with LPS induces biphasic accumulation of PI(4,5)P2 with peaks at 10 and 60-90 min that were still seen after silencing of TLR4 expression, questioning the involvement of TLR4 in this process.

  9. Data suggest that the transmembrane domains of Tlr4 and Tlr6 (zeige TLR6 Proteine) have essential roles in Tlr4/Tlr6 (zeige TLR6 Proteine)/Cd36 (zeige CD36 Proteine) receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.

  10. This study demonstrated that TLR4 deficiency contributes to regulating microglia to switch to the M2 phenotype, which ameliorates neurological impairment after traumatic brain injury in mice.

Cow (Bovine) Toll-Like Receptor 4 (TLR4) Interaktionspartner

  1. TLR4 polymorphisms are associated with lower reproductive Performance.

  2. As a pilot study, the present results revealed that identified SNPs in IL8 (zeige IL8 Proteine) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.

  3. Transcription levels of TLR2, TLR4, and CD14 (zeige CD14 Proteine) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.

  4. Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.

  5. TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.

  6. TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins

  7. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.

  8. Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (zeige CCL2 Proteine)) genes.

  9. Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle.

  10. Findings indicate that intervertebral disc (IVD (zeige IVD Proteine)) cells constitutively express TLR4.

Rabbit Toll-Like Receptor 4 (TLR4) Interaktionspartner

  1. TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.

  2. The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (zeige NFKB1 Proteine) (p65 (zeige SYT1 Proteine)) were respectively detected.

  3. Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.

  4. Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (zeige NFKB1 Proteine) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (zeige ICAM1 Proteine).

  5. TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage

  6. The elevated expression of TLR4 was detected after SAH (zeige ACSM3 Proteine) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (zeige ACSM3 Proteine).

Pig (Porcine) Toll-Like Receptor 4 (TLR4) Interaktionspartner

  1. These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (zeige MAMLD1 Proteine) in Meishan weaned piglets.

  2. Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (zeige IRF6 Proteine) challenge.

  3. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.

  4. Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.

  5. TLR2 is required for the suppression of TLR4 signaling activation.

  6. The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.

  7. The role of TLR2, TLR4 and RP105 (zeige CD180 Proteine)/MD1 (zeige LY86 Proteine) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (zeige CLPTM1 Proteine), is reported.

  8. Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.

  9. Fish Oil attenuates the activation of the HPA (zeige HPSE Proteine) axis induced by LPS (zeige IRF6 Proteine) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.

  10. Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.

Horse (Equine) Toll-Like Receptor 4 (TLR4) Interaktionspartner

  1. The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.

  2. A low steady expression of TLR4, MD-2 (zeige LY96 Proteine) and CD14 (zeige CD14 Proteine) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.

  3. In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.

  4. evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins

  5. TLR4/MD-2 (zeige LY96 Proteine) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.

TLR4 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TLR4

  • toll-like receptor 4 (TLR4)
  • toll-like receptor 4 (Tlr4)
  • ARMD10 Protein
  • CD284 Protein
  • Lps Protein
  • Ly87 Protein
  • Ran/M1 Protein
  • Rasl2-8 Protein
  • TLR-4 Protein
  • TOLL Protein

Bezeichner auf Proteinebene für Toll-Like Receptor 4 Proteine (TLR4)

hToll , homolog of Drosophila toll , lipopolysaccharide response , toll4 , Toll-like receptor4 protein , Toll-like receptor 4-like protein

GENE ID SPEZIES
7099 Homo sapiens
21898 Mus musculus
417241 Gallus gallus
29260 Rattus norvegicus
281536 Bos taurus
100009497 Oryctolagus cuniculus
100724803 Cavia porcellus
403417 Canis lupus familiaris
399541 Sus scrofa
493698 Felis catus
100066890 Equus caballus
100860955 Capra hircus
554263 Ovis aries
100980644 Pan paniscus
100689329 Cricetulus griseus
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