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Human TLR4 Protein expressed in Wheat germ - ABIN1322876
Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008
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This review speculate that the TLR4 signaling pathway may be a potential link between diabetes and Alzheimer's disease.
The 896G and 1196T SNPs in the TLR4 gene are associated with metastasis in liver neoplasms
PKCepsilon (zeige PRKCE Proteine) is a key upstream mediator in resistin (zeige RETN Proteine)-induced inflammation that may interact synergistically with TLR4 to promote NF-kB activation in macrophages.
TLR4 gene polymorphism plays a role in the common pathophysiology of CP and COPD (zeige ARCN1 Proteine), indicating that CP patients with TLR4 gene rs1927907 polymorphism may be more susceptible to COPD (zeige ARCN1 Proteine)
In conclusion, we could not detect any direct link between genotypes or allele frequencies of SNP rs4986790 in the TLR4 gene and POAG. In contrast, genotype (A/A) may be protective against POAG especially among individuals with no family history of glaucoma.
TLR4 rs4986790 and rs4986791 gene polymorphism is a risk for UTI (zeige AMBP Proteine) development.
This study showed that the induction level of IL-32 (zeige IL32 Proteine) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (zeige IRF6 Proteine)-induced IL-32 (zeige IL32 Proteine) expression in nasal polyp-derived fibroblasts was regulated via the TLR4/JNK (zeige MAPK8 Proteine)/AKT (zeige AKT1 Proteine)/CREB (zeige CREB1 Proteine) signaling pathway.
monocytes interact specifically with Chitosan-Fibrinogen (Ch-Fg) via TLR-4, triggering particular intracellular signalling pathways (ERK (zeige EPHB2 Proteine) and JNK (zeige MAPK8 Proteine), but not p38 (zeige CRK Proteine)), downstream of TLR-4. Functionally, Ch-Fg induced monocytes to produce the osteogenic mediator BMP-2 (zeige BMP2 Proteine).
TLR4 negatively regulates the proliferation of keratinocytes and its overexpression reduces tumor growth of SCC (zeige CYP11A1 Proteine) cells
The results highlight the importance of the inflammatory mediators, IFN-gamma (zeige IFNG Proteine) and TLR4, in the pathogenesis of aseptic loosening; increased pro-inflammatory status was associated with early time to revision, whereas IL-4 (zeige IL4 Proteine) correlated with longer implant survival
BCG (zeige SLC11A1 Proteine) increased membrane expression of TRIM59 through the TLR2/ TLR4/IRF5 (zeige IRF5 Proteine) pathway in RAW264.7 macrophage cell line.
this study shows that sophocarpine plays an anti-inflammatory role in LPS-induced mastitis by regulating TLR4 in mammary gland tissues
M. scrofulaceum induces a semimature DC phenotype that is characterized by PD-L2 (zeige PDCD1LG2 Proteine) over-expression and elevated synthesis of IL-10 (zeige IL10 Proteine), most likely through TLR4 and Raf-1 (zeige RAF1 Proteine) signaling pathway-dependent DC-SIGN (zeige CD209 Proteine) stimulation.
TLR4 deficiency prevented indomethacin-induced small intestinal damage
This study supports a role for TLR2 and TLR4 in periodontal disease and atherosclerosis, corroborating an intricate association between two inflammatory diseases.
Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis following lipopolysaccharide exposure through TLR4, which activates Nlrp3 (zeige NLRP3 Proteine), and subsequently induces caspase-1 (zeige CASP1 Proteine) activation.
The results indicate that adipose-derived mesenchymal stem cells (ADSCs) can increase the survival of fat transplants through the modulation of inflammatory and oxidative responses via Nrf2 (zeige NFE2L2 Proteine) and TLR4, suggesting potential strategies to improve the use of ADSCs for cell therapy.
Furthermore, it was observed that inflammatory cytokine levels were reduced in TLR2-/- mice after Treg transfer. Thus, these data indicate that TLR2/TLR4 regulate F. nucleatum-induced inflammatory cytokines through Tregs in vivo.
Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis
These effects were attenuated in BMDMs isolated from TLR4(-/-) mice.
STA3 (zeige ARHGEF3 Proteine) facilitates TLR4-dependent IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine) production via IL-6 (zeige IL6 Proteine) receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 (zeige IL8 Proteine) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 (zeige CD14 Proteine) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (zeige CCL2 Proteine)) genes.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (zeige NFKB1 Proteine) (p65 (zeige SYT1 Proteine)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (zeige NFKB1 Proteine) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (zeige ICAM1 Proteine).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (zeige ACSM3 Proteine) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (zeige ACSM3 Proteine).
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (zeige MAMLD1 Proteine) in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (zeige IRF6 Proteine) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105 (zeige CD180 Proteine)/MD1 (zeige LY86 Proteine) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (zeige CLPTM1 Proteine), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA (zeige HPSE Proteine) axis induced by LPS (zeige IRF6 Proteine) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 (zeige LY96 Proteine) and CD14 (zeige CD14 Proteine) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (zeige LY96 Proteine) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein