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results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with cholesterol metabolism in human adipose tissue
In hyperthyroidism, bone marrow resident macrophages have the potential to exert enhanced osteoprotective effects by oversecreting a TSH-beta splice variant.
In the context of metabolic syndrome, a higher TSH within the euthyroid range confers an increased leptin/adiponectin ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.
the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported.
Data suggest that the subtle thyroid-stimulating hormone (TSH) reduction could possibly reflect minor hypothalamic-pituitary damage.
analysis of a single nucleotide substitution in TSHbeta related to clinical euthyroidism [family case report]
Findings defined the immune-derived functional TSHb splice variant that resided in the thyroid of patients with Hashimoto's thyroiditis (HT), which exerted the unique effects on the pathogenesis of the disease.
Serum TSH was associated with pulse wave velocity on population level when adjusted with age and sex.
Higher TSH levels are associated with less favorable lipid levels in children
In cases with isolated central congenital hypothyroidism and undetectably low TSH serum concentrations, a TSHbeta gene deletion should be considered
Nitric oxide decreases TSH-induced FoxE1 (zeige FOXE1 ELISA Kits) expression, thus repressing the transcripcional activation of TPO (zeige TPO ELISA Kits) gene.
identification for the first time that ADAM10 is a TSHR cleavage enzyme and demonstration that TSH regulates its activation
subcutaneous adipose tissue Tshb expression levels correlated directly with circulating cholesterol levels
Oncogene (zeige RAB1A ELISA Kits)-induced senescence is initiated in Braf (zeige BRAF ELISA Kits)(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 (zeige TP53 ELISA Kits) expression by upregulating the PI3K/AKT (zeige AKT1 ELISA Kits) pathway and inhibiting OIS, resulting in tumor progression.
The observations indicate that the experimental system possesses responsiveness of the TSHbeta expression to melatonin.
PPARalpha (zeige PPARA ELISA Kits) modulates the TSH beta-subunit (zeige POLG ELISA Kits) mRNA expression in thyrotrope cells.
Tshb gene transcription was attenuated in MED1 (zeige MBD4 ELISA Kits) mutant mice in which the nuclear receptor-binding ability of MED1 (zeige MBD4 ELISA Kits) was specifically disrupted.
Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH.
Thyrotropin-releasing hormone (zeige TRH ELISA Kits) altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone (zeige PTH ELISA Kits).
PBF (zeige PTTG1IP ELISA Kits) is the first protein to interact with the critical TH transporter MCT8 (zeige MCT8 ELISA Kits) and modulate its function in vivo
thyroid-stimulating hormone and thyroid-stimulating hormone receptor (zeige TSHR ELISA Kits) antibodies have roles in osteoclastogenesis
Data demonstrate that Eya3 (zeige EYA3 ELISA Kits) and its partner Six1 (zeige SIX1 ELISA Kits) synergistically activate TSHbeta expression and that this activation is further enhanced by Tef (zeige TEF ELISA Kits) and Hlf (zeige HLF ELISA Kits).
mutation of the human homolog is a rare cause of hereditary hypothyrodism
thyrotropin beta chain
, thyrotropin subunit beta
, thyroid stimulating hormone, beta subunit
, thyroid-stimulating hormone subunit beta
, thyroid stimulating hormone, beta polypeptide
, thyrotropin beta subunit
, thyroid-stimulating hormone beta subunit
, thyrotropin beta-subunit