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Data show that inducible T cell co-stimulator (ICOS) deficient mice have a significant increase in the population of IL-17 (zeige IL17A ELISA Kits)-producing Vgamma2+ gammadelta T cells in the thymus, spleen, lymph nodes and skin and exhibit exacerbated sensitization responses to 2,4-dinitrofluorobenzene.
Our results indicate that ICOS regulates the ontogeny and homeostasis of B6.Sle1 lupus prone mouse T follicular helper (TFH) cells and influences the function of TFH cells during aberrant germinal center B cell responses
The expression of ICOSL (zeige ICOSLG ELISA Kits) in the cornea and the ICOS-mediated induction of Foxp3 (zeige FOXP3 ELISA Kits)+ CD4 (zeige CD4 ELISA Kits)+ regulatory T cells may contribute to successful corneal allograft survival.
this study reveals a previously unknown ICOS-TBK1 (zeige TBK1 ELISA Kits) signaling pathway that specifies the commitment of germinal center follicular helper T cells
IFNAR1 (zeige IFNAR1 ELISA Kits)-deficiency accelerated humoral immune responses and parasite control by boosting ICOS-signalling in two non-lethal murine models of malaria
Fecal levels of Crp1 (zeige CRIP1 ELISA Kits) were significantly decreased in mice with graft-versus-host disease and were correlated with intestinal flora diversity.
IL-10 (zeige IL10 ELISA Kits) production by CD4 (zeige CD4 ELISA Kits)(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 (zeige IL27 ELISA Kits) receptor signaling that is supported after CD4 (zeige CD4 ELISA Kits)(+) T cell priming by ICOS signaling.
these data suggest ICOS is not required for follicular Th cell induction during Plasmodium chabaudi chabaudi AS infection
the ICOS signaling has a regulatory effect on CD154 (zeige CD40LG ELISA Kits)/CD40 (zeige CD40 ELISA Kits) expressions, and may play an important role in the hepatic egg granuloma formation of schistosomiasis.
data identify a role of ICOS in innate immunity and indicate that not only cytokines, but also costimulatory pathways such as those involving ICOS, can contribute to regulate the ILC2 pool.
OX40 (zeige TNFRSF4 ELISA Kits) and ICOS (zeige CTLA4 ELISA Kits) act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper cell response that is generated after acute virus infection
High ICOS (zeige CTLA4 ELISA Kits) expression is associated with colorectal neoplasms.
This is the first replication association study of rs4325730 upstream of ICOS (zeige CTLA4 ELISA Kits) with AIH in the Japanese population and rs4325730G is a risk allele.
the induction pathway of ICOS (zeige CTLA4 ELISA Kits)(+) Foxp3 (zeige FOXP3 ELISA Kits)(+) cells was analyzed
ratio of ICOS (zeige CTLA4 ELISA Kits)(+) /PD-1 (zeige PDCD1 ELISA Kits)(+) Tfh cells and the frequency of IL-21 (zeige IL17C ELISA Kits)(+) Tfh cells may be indicators for evaluating the idiopathic membranous nephropathy development
The ICOS (zeige CTLA4 ELISA Kits) and ICOSL (zeige ICOSLG ELISA Kits) SNPs examined do not have an apparent effect on the disease susceptibility and prognosis of autoimmune thyroid diseases.
Follicular helper T cells differentiation is a multistage process involving BCL6 (zeige BCL6 ELISA Kits) and other transcription factors, cytokines, and costimulation through ICOS (zeige CTLA4 ELISA Kits) and several other molecules. (Review)
findings show Tregs from inflamed lung of sarcoidosis patients characterized by ICOS (zeige CTLA4 ELISA Kits)(high) phenotype; high-level ICOS (zeige CTLA4 ELISA Kits) expression was restricted to Tregs from inflamed lung and was absent in blood Tregs of sarcoidosis patients and in lung and blood Tregs of healthy volunteers; potential implication of ICOS/ICOS (zeige CTLA4 ELISA Kits)-L (zeige ICOSLG ELISA Kits) immune-regulatory axis in in disease activity and resolution
findings indicated that circulating memory Tfh cells, especially CCR7 (zeige CCR7 ELISA Kits)+ICOS (zeige CTLA4 ELISA Kits)+ memory Tfh cells, may be associated with the relapse of MS and may serve as a new therapeutic target
Expression of mutant caspase-9 (zeige CASP9 ELISA Kits) correlated with a downregulation of BAFFR (zeige TNFRSF13C ELISA Kits) (B-cell-activating factor (zeige TNFSF13B ELISA Kits) belonging to the TNF (zeige TNF ELISA Kits) family (BAFF) receptor (zeige TNFRSF13C ELISA Kits)) in B cells and ICOS (inducible T-cell costimulator) in T cells.
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
inducible T-cell costimulator
, inducible T-cell co-stimulator
, CD28 and CTLA-4-like protein
, CD28-related protein 1
, activation-inducible lymphocyte immunomediatory molecule
, inducible costimulator