Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Proteine (SNTA1)

Bezeichnung:
Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Proteine (SNTA1)
Auf www.antikoerper-online.de finden Sie aktuell 7 Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Antikörper (86) und Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 102 Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Produkte verfügbar.
Synonyme:
AW228934, dJ1187J4.5, LQT12, MGC147484, SNT1, SNTA1, TACIP1
alle Proteine anzeigen Gen GeneID UniProt
SNTA1 20648  
SNTA1 6640 Q13424
Ratte SNTA1 SNTA1 362242  

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Am meisten referenzierte Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Proteine

  1. Human SNTA1 Protein expressed in Escherichia coli (E. coli) - ABIN668003 : Newey, Benson, Ponting, Davies, Blake: Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. in Current biology : CB 2001 (PubMed)
    Zeige alle 2 Referenzen für 668003

Weitere Proteine zu Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Interaktionspartnern

Xenopus laevis Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) Interaktionspartner

  1. Ordered disorder of the astrocytic dystrophin (zeige DMD Proteine)-associated protein complex in the norm and pathology.

Mouse (Murine) Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) Interaktionspartner

  1. alpha-syntrophin plays a pivotal role in the survival pathway triggered by menadione-induced oxidative stress in cultured myoblasts.

  2. Alpha-syntrophin deficiency markedly reduces astrocyte swelling during severe hypoosmotic stress/brain edema.

  3. Isolated muscle bundles from SNTA1 mutant mice showed reduced force production after hypo-osmotic shock. In addition, the mutant muscle bundles showed delayed recovery of specific gravity after being exposed to hypo-osmotic conditions.

  4. Ordered disorder of the astrocytic dystrophin (zeige DMD Proteine)-associated protein complex in the norm and pathology.

  5. alpha-Syntrophin, which resides in nuclei of myocytes, functions as the upstream mediator of nuclear nNOS (zeige NOS1 Proteine) translocation and nNOS (zeige NOS1 Proteine)-dependent mitochondrial biogenesis.

  6. the removal of the perivascular pool of AQP4 (zeige AQP4 Proteine) due to alpha-syntrophin deletion reduces edema formation, especially under pathological conditions and during states associated with elevated K+.

  7. Scaffold proteins alpha-syntrophin and dystrophin (zeige DMD Proteine) exhibit lower densities in retinal microglia compared with brain astrocytes.

  8. The interaction between the conserved COOH-terminal 125-amino acid domain (which is located in the light chains of MAP1A (zeige MAP1A Proteine), MAP1B (zeige MAP1B Proteine), and MAP1S (zeige MAP1S Proteine)) and alpha1-syntrophin is direct and occurs through the pleckstrin (zeige PLEK Proteine) homology domain 2 (PH2 (zeige PhC2 Proteine)).

  9. Data show that in Dp71 (zeige DMD Proteine)-null mice, the levels of beta-dystroglycan (beta-DG) and alpha1-syntrophin (alpha1-Syn (zeige SYP Proteine)) were lower and utrophin expression did not change, and the neuronal nitric oxide synthase (nNOS (zeige NOS1 Proteine)) expression and activity were increased.

  10. We identified alpha1-syntrophin, a component of the dystrophin (zeige DMD Proteine)-associated protein complex (DAPC), as a myocilin (zeige MYOC Proteine)-binding candidate.

Human Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) Interaktionspartner

  1. A novel SNTA1 variant is likely causative for drug induced long-QT syndrome by augmenting the late sodium current.

  2. In a nonreferred nationwide Danish cohort of SIDS (zeige IDS Proteine) cases, up to 5/66 (7.5%) of SIDS (zeige IDS Proteine) cases can be explained by genetic variants in the sodium channel complex genes.

  3. our results present a possible mechanism of Rac1 activation involving SNTA1 and emphasise its role in ROS (zeige ROS1 Proteine) generation, cell migration, and acquisition of malignancy.

  4. Ordered disorder of the astrocytic dystrophin (zeige DMD Proteine)-associated protein complex in the norm and pathology.

  5. alpha-Syntrophin, which resides in nuclei of myocytes, functions as the upstream mediator of nuclear nNOS (zeige NOS1 Proteine) translocation and nNOS (zeige NOS1 Proteine)-dependent mitochondrial biogenesis.

  6. Calcium homeostasis mishandling in Duchenne muscular dystrophy (zeige DMD Proteine) myotubes depends on store operated calcium entry under the influence alpha1-syntrophin regulation as well as TRPV2 (zeige TRPV2 Proteine)-dependant cation influx.

  7. The combined mutations of A261V-SNTA1 plus R800L-SCN5A (zeige SCN5A Proteine) increase the INa (zeige INA Proteine) current late/peak ratio and time constants of current decay.

  8. In contrast to stomach, lung, colon and rectal cancers, SNTA1 protein was found to be downregulated in esophageal cancers and upregulated in breast cancer.

  9. alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction

  10. These results establish an SNTA1-based nNOS (zeige NOS1 Proteine) complex attached to SCN5A (zeige SCN5A Proteine) as a key regulator of sodium current and suggest that SNTA1 be considered a rare long QT syndrome-susceptibility gene.

Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) Protein Überblick

Protein Überblick

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.

Alternative names and synonyms associated with Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1)

  • syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) (SNTA1)
  • syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) (snta1)
  • syntrophin, acidic 1 (Snta1)
  • syntrophin, alpha 1 (SNTA1)
  • syntrophin, alpha 1 (Snta1)
  • AW228934 Protein
  • dJ1187J4.5 Protein
  • LQT12 Protein
  • MGC147484 Protein
  • SNT1 Protein
  • SNTA1 Protein
  • TACIP1 Protein

Bezeichner auf Proteinebene für SNTA1

syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) , 59 kDa dystrophin-associated protein A1 acidic component 1 , alpha-1-syntrophin , alpha1-syntrophin , syntrophin-1 , acidic alpha 1 syntrophin , dystrophin-associated protein A1, 59kDa, acidic component , pro-TGF-alpha cytoplasmic domain-interacting protein 1 , syntrophin, acidic 1 , 59-1 DAP , alpha-syntrophin

GENE ID SPEZIES
458181 Pan troglodytes
496157 Xenopus laevis
709824 Macaca mulatta
780141 Xenopus (Silurana) tropicalis
100597246 Nomascus leucogenys
20648 Mus musculus
6640 Homo sapiens
362242 Rattus norvegicus
485837 Canis lupus familiaris
100151843 Sus scrofa
100009179 Oryctolagus cuniculus
527488 Bos taurus
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