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Mammalian Monoclonal NLGN3 Primary Antibody für ISt, IHC - ABIN1304858
Proctor, Stotz, Scott, de la Hoz, Poon, Stys, Colicos: Axo-glial communication through neurexin-neuroligin signaling regulates myelination and oligodendrocyte differentiation. in Glia 2015
Show all 4 Pubmed References
Rat (Rattus) Polyclonal NLGN3 Primary Antibody für ELISA, WB - ABIN1742288
Suckow, Comoletti, Waldrop, Mosedale, Egodage, Taylor, Chessler: Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. in Endocrinology 2008
Show all 2 Pubmed References
Human Polyclonal NLGN3 Primary Antibody für ELISA, WB - ABIN256738
Tabuchi, Blundell, Etherton, Hammer, Liu, Powell, Südhof: A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. in Science (New York, N.Y.) 2007
No statistically significant haplotypes have been found associated to autism in the NLGN3 after logistic regression and permutation analysis.
The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust high-grade glioma cell proliferation.
Our data provided a further evidence for the involvement of NLGN3 and NLGN4X (zeige NLGN4X Antikörper) gene in the pathogenesis of autism in Chinese population.
The present study explores, for the first time, the contribution of NLGN3 and NLGN4X (zeige NLGN4X Antikörper) genetic variants in Greek patients with autistic disorder.
Lack of association between NLGN3, NLGN4 (zeige NLGN4X Antikörper), SHANK2 (zeige SHANK2 Antikörper) and SHANK3 (zeige SHANK3 Antikörper) gene variants and autism spectrum disorder in a Chinese population.
Neuroligins are adhesion proteins that bind to beta-neurexin (zeige NRXN1 Antikörper) to form functional synapses.
Data from studies using cross-linking reagents suggest that neuroligins form dimers, including homodimers and, most notably, neuroligin 1 (zeige NLGN1 Antikörper)/3 heteromers; autism-associated neuroligin mutant (neuroligin 3 R471C) forms heterodimers with neuroligin 1 (zeige NLGN1 Antikörper).
study provides initial evidence that a common variant in NLGN3 gene may play a role in the etiology of ASDs among affected males in Chinese Han population.
further characterization of the R451C mutation in NLGN3;role in protein folding
report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 (zeige NLGN4X Antikörper) in siblings with autism-spectrum disorders
The NL3 deletion-mutant mouse was a dramatic reduction of the number of GABAAalpha2-subunit containing GABAA (zeige GABRg1 Antikörper) receptor clusters at the retinal inner plexiform layer.
that neuroligin-3 specifies the properties of excitatory synapses on parvalbumin (zeige PVALB Antikörper)-containing interneurons by a retrograde trans-synaptic mechanism and suggest a molecular pathway whereby neuroligin-3 mutations contribute to neuropsychiatric disorders
Study shows altered mating behavior in the Neuroligin-3(R451C mutation) mouse and has provides new insights into the aggressive phenotype in this model.
Nlgn3 and Nrxn1 (zeige NRXN1 Antikörper) are differentially expressed in cerebral cortex and hippocampus which might be responsible for alternations in synaptic plasticity during aging.
These findings suggest that structural changes in the brain of NL-3 mice are induced by the mutation in the NL-3 gene
Thus our data suggest that perinatal exposure to BPA (zeige DST Antikörper) impairs spatial memory through upregulation of expression of synaptic proteins Nrxn1 (zeige NRXN1 Antikörper) and Nlgn3 and increased dendritic spine density in cerebral cortex and hippocampus of postnatal male mice.
Therefore, we sought to replicate our findings in the neuroligin-3 R451C point mutant knock-in mouse model (NL3R451C) in a different genetic background.
We used MRI to image three genetic mouse models with single mutations implicated in autism: Neuroligin-3 R451C knock-in, Methyl-CpG binding protein-2 (MECP2) 308-truncation and integrin beta3 homozygous knockout.
Results indicate that autism spectrum disorders (ASD (zeige GUSB Antikörper))-associated NL3 mutations commonly disrupt striatal circuits in a subregion-, cell-type-, and synapse-specific fashion and suggest that this disruption may shape repetitive and stereotypic behaviors associated with ASD (zeige GUSB Antikörper).
Neuroligin-3 R704C-mutant induced neurons exhibit a large and selective decrease in AMPA (zeige GRIA3 Antikörper)-type glutamate (zeige GRIN1 Antikörper) receptor-mediated synaptic transmission without changes in NMDA-type glutamate (zeige GRIN1 Antikörper) receptor- or in GABAA (zeige GABRg1 Antikörper) receptor-mediated synaptic transmission.
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
, neuroligin 3 isoform A1A2
, carboxylesterase clade L, member 3
, gliotactin homolog
, neuroligin 3 protein