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Our findings highlight the influence of UGTT1A4 haplotypes on tamoxifen disposition in Asian breast cancer patients, while genetic variants in UGT2B7 and UGT2B15 (zeige UGT2B15 ELISA Kits) appear to be of minor importance.
Neither AUC0-150min, ktr, CL, nor VD were associated with genetic variants in OCT1 (zeige POU2F1 ELISA Kits), ABCB1 (zeige ABCB1 ELISA Kits), and UGT2B7 (all P>0.05).
This study aimed to analyze the relationship of UGT2B7 and UGT1A4 (zeige UGT1A4 ELISA Kits) polymorphisms with metabolism of valproic acid (VPA) and lamotrigine (LTG (zeige TNFSF14 ELISA Kits)) in epileptic children. UGT2B7 A268G and C802T polymorphisms were demonstrated to affect the serum concentration of VPA (F=3.147, P=0.047; F=22.754, P=0.000). we found that C802T polymorphism exerted strong effects on efficacy of VPA (chi2=9.265, P=0.010).
UGT2B7 contributes to the in-vitro glucuronidation of arctigenin in liver/intestinal microsomes.
Influence of valproic acid concentration and polymorphism of UGT1A4 (zeige UGT1A4 ELISA Kits)*3, UGT2B7 -161C > T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children
Significant differences in mean dose consumption were seen among the genotypic groups of the OPRM1 (zeige OPRM1 ELISA Kits) A118G and UGT2B7 C802T variants. These variants were found to predict codeine consumption in the cohort overall and among Caucasians
aprepitant can alter clearance of drugs primarily eliminated by UGT2B7.
The presence of the SNP 802C>T UGT2B7 (UGT2B7*2/*2) is associated with a worse analgesic response to transdermal buprenorphine in the postoperative period of thoracic surgery.
Results show ticagrelor pharmacokinetics to be influenced by SNPs in UGT2B7 though no detectable effects on efficacy or safety were found
This descriptive study examines correlations between concentrations of tamoxifen's glucuronide metabolites and genotypes UGT1A4 (zeige UGT1A4 ELISA Kits), UGT2B7, UGT2B15 (zeige UGT2B15 ELISA Kits) and UGT2B17 (zeige UGT2B17 ELISA Kits) in 132 patients with estrogen receptor (zeige ESR1 ELISA Kits)-positive breast cancer under treatment with tamoxifen
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.
UDP glycosyltransferase 2 family, polypeptide B28
, UDP glucuronosyltransferase 2 family, polypeptide B7
, UDP-glucuronosyltransferase 2B7
, UDP-glucuronosyltransferase 2B7-like
, 3,4-catechol estrogen specific
, 3,4-catechol estrogen-specific UDPGT
, UDP glucuronosyltransferase 2B7
, UDP-glucuronosyltransferase 2B9
, UDP-glucuronyltransferase, family 2, beta-7
, UDPGT 2B7
, UDP-glucuronosyltransferase 2B8
, UDPGT 2B8