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Extending the lifespan of normal human cells due to inactivation of STAG2 could promote tumorigenesis by extending the period during which tumor-driving mutations occur.
Loss of STAG2 or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines.
the clinical features of these three cases are remarkably similar to those observed in other well-established cohesinopathies. Herein, we suggest that STAG2 is a dosage-sensitive gene and that heterozygous loss-of-function variants lead to a cohesinopathy.
results indicated that the complete loss of STAG2 expression was predictive for better recurrence-free survival and cancer-specific survival, suggesting its potential value as a prognostic biomarker in bladder cancer
We suggest that increased STAG2 gene copy number and dysregulation of its downstream target genes may be responsible for the specific clinical findings of this syndrome.
Characterization of C-terminal nuclear localization signal of the human SA2 stromalin
Data show a significantly higher stromal antigen 2 (STAG2) mRNA and protein levels in normal bladder cells than bladder cancer cells.
Microduplication of chromosome Xq25 encompassing STAG2 gene in a boy with intellectual disability
STAG2 promotes the correction of kMT (zeige CAMKMT Proteine) attachment errors to ensure faithful chromosome segregation during mitosis.
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 (zeige TP53 Proteine) mutations
Our genetic analysis demonstrates that cohesins containing STAG3 and REC8 (zeige REC8 Proteine) are the main complex required for centromeric cohesion, and RAD21L (zeige RAD21L1 Proteine) cohesins are required for normal clustering of pericentromeric heterochromatin. Furthermore, the STAG3/REC8 (zeige REC8 Proteine) and STAG3/RAD21L (zeige RAD21L1 Proteine) cohesins are the primary cohesins required for axis formation.
our data suggests that STAG3 is required for structural changes of chromosomes that mediate chromosome pairing and synapsis, DNA repair and progression of meiosis.
STAG3 is a strong candidate gene for male infertility
STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin.
STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.
a cohesin complex containing Rad21 and STAG2 cooperates with a STAG3-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis
E2F6 silences SMC1beta and STAG3 in somatic cells
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
stromal antigen 2
, stromal antigen 2, isoform 1
, SCC3 homolog 2
, cohesin subunit SA-2
, nuclear protein SA2
, cohesin subunit XSA2
, stromal antigen 2 homolog
, SCC3 homolog 3
, cohesin subunit SA-3
, stromalin 3