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The absence of deleterious mutations in this large cohort of familial aggregations of hematological malignancies may strengthen the hypothesis that GATA2 mutations are an important predisposing factor, although as a secondary genetic event, required for the development of overt malignant disease
Gata2 regulates a key regulatory network of gene expression for progesterone signaling at the early pregnancy stage.
p38 (zeige CRK ELISA Kits)-dependent mechanism that phosphorylates GATA-2 and increases GATA-2 target gene activation has been demonstrated. This mechanism establishes a growth-promoting chemokine (zeige CCL1 ELISA Kits)/cytokine circuit in acute myeloid leukemia (zeige BCL11A ELISA Kits) cells.
we report a family with a null mutation in GATA2 and Emberger syndrome with variable expressivity and incomplete penetrance. This case emphasizes the need of genetic interactions to produce specific phenotypes in the clinical spectrum of GATA2 deficiency, where no precise genotype-phenotype correlation has been found.
Studied GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers. Seven patients with GATA2 deficiency developed severe EBV disease. Also found GATA2 to be the first gene associated with EBV hydroa vacciniforme-like lymphoma.
GATA2 deficiency is associated with impaired membrane expression and chemotactic dysfunctions of CXCR4 (zeige CXCR4 ELISA Kits).
decline of GATA2 resulting from mutations contributes to the erythroid commitment, differentiation and the development of AEL
the distinct mechanisms by which GATA2 and FOXA1 (zeige FOXA1 ELISA Kits) regulate AR cistrome and suggest that FOXA1 (zeige FOXA1 ELISA Kits) acts upstream of GATA2 and AR in determining hormone-dependent gene expression in prostate cancer.
adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire.
reducing GATA2 expression or inhibition of its transcription activity can relieve the drug resistance of acute myeloid leukemia (zeige BCL11A ELISA Kits) cells and it would be helpful for eliminating the leukemia cells in patients
bcar3 gene is expressed downstream of Gata2 during gastrulation, and is co-expressed with gata2 but is more broadly expressed during later development; its binding partner, bcar1 (zeige BCAR1 ELISA Kits) shows overlapping expression patterns
results are consistent with a model in which GATA2 contributes to inhibition of canonical Wnt (zeige WNT2 ELISA Kits) signaling
these findings, strongly implicate Dlx3 in the regulation of non-neural competence, and show that GATA2 contributes to non-neural competence but is not sufficient to promote it ectopically.
Studies suggest a two-component model for the binding of CBTF (zeige MMP4 ELISA Kits) with gata2 promoter, requiring both a CCAAT and A-form DNA, and the double stranded RNA binding domains (dsRBDs) of CBTF (zeige MMP4 ELISA Kits) component Xilf3 (zeige MMP4 ELISA Kits) must be active for both binding to the promoter.
Gata-2 is a transcriptional target downstream of BMPs within ectodermal cells, while activation of the CaM KIV signaling pathway alters GATA-2 function posttranslationally, by inhibiting its acetylation.
GATA2 and/or GATA3 (zeige GATA3 ELISA Kits) are involved in the regulation of trophoblast-specific gene transcription in bovine trophoblast CT-1 (zeige SLC6A8 ELISA Kits) cells
GATA2 could affect the function of BM-MSCs in vivo, presumably by regulating the expression of extracellular signals.
Results show that GATA2 exerts a pro-inflammatory function in injured kidney collecting duct cells, by upregulating inflammatory cytokine gene expression thereby contributes to disease progression.
Gata2 mRNA levels were almost completely rescued by expression of an erythroid lineage restricted ROSA26-promotor based GATA2 transgene
Gata2 heterozygous deletion confers selective advantage to EVI1 (zeige MECOM ELISA Kits)-expressing leukemia cell expansion in recipient mice
impairment of trophoblast-specific GATA2/GATA3 (zeige GATA3 ELISA Kits) function could lead to early pregnancy failure
both Gata2 and Gata3 (zeige GATA3 ELISA Kits) are redundantly required for differentiation of the serotonergic and glutamatergic neurons of the dorsal raphe
Dynamically and epigenetically coordinated GATA2/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.
High GATA2 expression is associated with leukemia.
results suggest that GATA2 plays an important role in cell-fate specification toward the myeloid vs T-lymphocyte lineage by regulating lineage-specific transcription factors in DC progenitors, thereby contributing to DC differentiation.
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.
GATA binding protein 2
, glutamyl/aspartyl-tRNA(Gln/Asp) amidotransferasesubunit A
, hypothetical protein
, protein GatA2
, GATA2 transcription factor
, endothelial transcription factor GATA-2-like
, endothelial transcription factor GATA-2
, GATA binding factor-2
, GATA-binding factor 2
, transcription factor xGATA-2
, transcription factor NF-E1B
, transcription factor GATA-2
, GATA-binding protein 2
, GATA-bindning protein 2