anti-GJB2 (GJB2) Antikörper

Bezeichnung:
anti-Gap Junction Protein, beta 2, 26kDa Antikörper (GJB2)
Auf www.antikoerper-online.de finden Sie aktuell 88 Gap Junction Protein, beta 2, 26kDa (GJB2) Antikörper von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GJB2 Kits (32) und GJB2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 129 GJB2 Produkte verfügbar.
Synonyme:
AI325222, Cnx26, connexin-26, CX26, CXN-26, DFNA3, DFNA3A, DFNB1, DFNB1A, Gjb-2, GJB2, HID, KID, MGC53062, NSRD1, PPK

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anti-Mouse (Murine) GJB2 Antikörper:

anti-Rat (Rattus) GJB2 Antikörper:

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Am meisten referenzierte anti-GJB2 Antikörper

  1. Cow (Bovine) Polyclonal GJB2 Primary Antibody für WB - ABIN2774858 : Ulfig: Expression of connexin 26 in the ganglionic eminence of preterm infants after bleedings. in Neuroscience research 2004 (PubMed)

  2. Mouse (Murine) Polyclonal GJB2 Primary Antibody für ELISA, WB - ABIN190896 : Djalilian, McGaughey, Patel, Seo, Yang, Cheng, Tomic, Sinha, Ishida-Yamamoto, Segre: Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. in The Journal of clinical investigation 2006 (PubMed)

Weitere Antikörper gegen GJB2 Interaktionspartner

Xenopus laevis Gap Junction Protein, beta 2, 26kDa (GJB2) Interaktionspartner

  1. Using reconstituted hemichannels in a liposome-based transport-specific fractionation assay, we confirmed that homomeric Cx26 and Cx32 (zeige GJB1 Antikörper) and heteromeric Cx26/Cx32 (zeige GJB1 Antikörper) are permeable to GSH and other endogenous reductants.

Mouse (Murine) Gap Junction Protein, beta 2, 26kDa (GJB2) Interaktionspartner

  1. The hearing loss and the reduction of active amplification in the Cx26 targeted-deletion mice are progressive and different at high and low frequency regions, first occurring in the high frequency region and then progressively extending to the middle and low frequency regions with mouse age increased.

  2. In connexin knock-outs, Cx26 and Cx30 (zeige GJB6 Antikörper), inner hair cells remained stuck at a prehearing stage of development.

  3. Reduced Cx26 expression in the mature mouse cochlea may increase susceptibility to noise-induced hearing loss .

  4. mir (zeige MLXIP Antikörper)-27a was identified as an apoptotic molecule that participates in Cx26 knockout-induced apoptosis in the cochlear sensory epithelium of mice by downregulating sgk1 (zeige SGK1 Antikörper) expression

  5. Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer.

  6. Cx26-mediated intercellular communication is required for cochlear development and that deficiency of Cx26 can impair miRNA-mediated intercellular genetic communication in the cochlea, which may lead to cochlear developmental disorders

  7. presence of Cx30 (zeige GJB6 Antikörper) in the cochlea does not compensate for Cx26 loss, and the absence of both connexins from vestibular sensory epithelia is no more injurious than the absence of one of them

  8. Reciprocal positive regulation between Cx26 and PI3K/Akt (zeige AKT1 Antikörper) pathway confers acquired gefitinib resistance in non-small-cell lung carcinoma cells by promoting epithelial mesenchymal transition via a gap-junctional communication-independent manner.

  9. The inserting reconstituted gap junction Cx26 liposomes into the oocytes allowed the demonstration of intracellular/extracellular Ca(2 (zeige CA2 Antikörper)+)-regulated hemi-channel activities.

  10. Study used an inducible gene knockout technique to delete Cx26 expression in the cochlea after birth, results suggest that Cx26 deficiency may impair active cochlear amplification leading to late-onset hearing loss

Human Gap Junction Protein, beta 2, 26kDa (GJB2) Interaktionspartner

  1. GJB2 and ERO1LB (zeige ERO1LB Antikörper) are implicated in pancreatic cancer progression and can be used to predict patient survival

  2. Significant proportion of children with unilateral sensori-neural hearing loss may have positive genetic testing while the vast majority of these children present with heterozygous mutations of connexin 26 (GJB2)

  3. WFS1 (zeige WFS1 Antikörper) and GJB2 mutations were identified in eight of 74 cases of Low-Frequency Sensorineural Hearing Loss. Four cases had heterozygous WFS1 (zeige WFS1 Antikörper) mutations; one had a heterozygous WFS1 (zeige WFS1 Antikörper) mutation and a heterozygous GJB2 mutation; and three cases had biallelic GJB2 mutations. Three cases with WFS1 (zeige WFS1 Antikörper) mutations were sporadic; two of them were confirmed to be caused by a de novo mutation based on the genetic analysis of their parents.

  4. results demonstrate that 19.2% patients with nonsyndromic deafness were caused by mutations in three common deafness genes (GJB2, SLC26A4 (zeige SLC26A4 Antikörper) and 12S rRNA) in our northern China patient group

  5. GJB2-related deafness leads to significantly better cochlear implantation outcomes when compared with acquired deafness caused by environmental etiologies. However, GJB2 mutation is not associated with a significantly better prognosis when compared with those whose deafness results from either nonsyndromic hearing loss of unknown origin or other types of genetic mutations in the absence of other neurologic deficits.

  6. expression of Cx26 (also known as GJB2) in HeLa cells specifically enhances cell motility in scrape wounding and sparse culture models.

  7. Results found that the contribution of the GJB2 gene pathogenic variants to hearing impairment in the population of the Sakha Republic was the highest among all of the regions of Asia studied previously suggesting that extensive accumulation of the c.-23+1G>A pathogenic variant in the indigenous Yakut population may indicate the possible selective advantage of the c.-23+1G>A carriers living in the subarctic climate.

  8. Reduced expression of Cx26 and Cx43 (zeige GJA1 Antikörper) is implicated in the pathophysiology of colonic dysmotility in the aganglionic bowel as well as, in the case of Cx26, the ganglionic bowel in Hirschsprung's disease.

  9. These findings suggest that Cx26 mutants that promote cell death or exert transdominant effects on other connexins in keratinocytes will lead to skin diseases and hearing loss

  10. Cx26-Asp50Asn with the second-site mutations identified in the patient displayed no formation of gap junction channel plaques. We argue that the second-site mutations independently inhibit Cx26-Asp50Asn expression in gap junction channels, reverting the dominant negative effect of the p.Asp50Asn mutation

Cow (Bovine) Gap Junction Protein, beta 2, 26kDa (GJB2) Interaktionspartner

  1. intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26, Cx32 (zeige GJB1 Antikörper), and Cx43 (zeige GJA1 Antikörper)

GJB2 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.

Alternative names and synonyms associated with GJB2

  • gap junction protein, beta 2, 26kDa (gjb2) Antikörper
  • gap junction protein, beta 2, 26kDa (GJB2) Antikörper
  • gap junction protein, beta 2 (Gjb2) Antikörper
  • AI325222 Antikörper
  • Cnx26 Antikörper
  • connexin-26 Antikörper
  • CX26 Antikörper
  • CXN-26 Antikörper
  • DFNA3 Antikörper
  • DFNA3A Antikörper
  • DFNB1 Antikörper
  • DFNB1A Antikörper
  • Gjb-2 Antikörper
  • GJB2 Antikörper
  • HID Antikörper
  • KID Antikörper
  • MGC53062 Antikörper
  • NSRD1 Antikörper
  • PPK Antikörper

Bezeichner auf Proteinebene für GJB2

gap junction protein, beta 2, 26kDa , connexin 26 , connexin 29 , gap junction membrane channel protein beta 6 , gap junction protein, beta 2, 26kDa (connexin 26) , connexin-26 , gap junction beta-2 protein , gap junction membrane channel protein beta 2 , gap junction channel protein connexin 26 , connexin26 , gap junction protein beta 2 , connexin 26 protein , cx26

GENE ID SPEZIES
380170 Xenopus laevis
467220 Pan troglodytes
14619 Mus musculus
394266 Rattus norvegicus
100379528 Cavia porcellus
2706 Homo sapiens
403570 Canis lupus familiaris
407154 Bos taurus
443345 Ovis aries
704224 Macaca mulatta
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