Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA (zeige NTRK1 ELISA Kits) and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC (zeige NTRK3 ELISA Kits) was faintly detected
BDNF (zeige BDNF ELISA Kits)-TrkB influences the expression level of components of chemokine (zeige CCL1 ELISA Kits) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF (zeige BDNF ELISA Kits)/TrkB2 system in the adult zebrafish retina.
Study showed that complex relationships exist between BDNF (zeige BDNF ELISA Kits)/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
Data suggest that high expression of TRKB (not TRKA (zeige NTRK1 ELISA Kits) or TRKC (zeige NTRK3 ELISA Kits)) in lung squamous cell carcinoma is correlated with vascular invasion, lymph node metastasis, advanced stage of tumor, and poor prognosis; overall survival of patients with TRKB-high expression is significantly shorter than those with TRKB-low expression; RNA interference against TRKB or BDNF (zeige BDNF ELISA Kits) (TRKB agonist) inhibits cell proliferation of tumor cell line.
Among the adaptations observed following consumption of drugs of abuse or alcohol abuse, BDNF (zeige BDNF ELISA Kits) levels are widely altered in both brain and periphery. Data suggest that BDNF (zeige BDNF ELISA Kits)/TRKB signaling in neurons in specific areas of brain (hippocampus, nucleus accumbens) is altered in protracted withdrawal from drug/alcohol abuse. [REVIEW]
Data suggest that kinase domains of neurotrophin (zeige BDNF ELISA Kits) receptor isoforms, TRKA (zeige NTRK1 ELISA Kits), TRKB, and TRKC (zeige NTRK3 ELISA Kits), exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan-Trk (zeige NTRK1 ELISA Kits) immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
High TRKB expression is associated with Small Cell Lung Cancer.
Co-immunoprecipitation and biochemical fractionation data suggested that p75 (zeige CUX1 ELISA Kits) TM stimulates TrkB phosphorylation at the cell membrane.
High NTRK2 expression is associated with astrocytomas.
overexpression of TrkB, but not of BDNF (zeige BDNF ELISA Kits), is significantly associated with a poor survival outcome for TNBC patients.
In the current work, we provide a global analysis of the physiological consequences of TrkB receptor activation in vitro and discuss the dynamic consequences of TrkB activation in vivo. Finally, we propose a clinically-feasible option for increasing BDNF (zeige BDNF ELISA Kits) expression in the hypothalamus to more readily utilize the oncolytic effects of BDNF (zeige BDNF ELISA Kits).
ShcD binds to active Ret (zeige RET ELISA Kits), TrkA (zeige NTRK1 ELISA Kits), and TrkB neurotrophic factor (zeige NTF3 ELISA Kits) receptors predominantly via its phosphotyrosine-binding (PTB (zeige PTBP1 ELISA Kits)) domain.
The three receptor sets considered (mAChR (zeige CHRM3 ELISA Kits), AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
Signaling through postsynaptic trkB receptors is considered to be an essential part of a cellular mechanism for maintaining the contacts of some, but not all, synaptic contacts onto motoneurons
findings show that BDNF (zeige BDNF ELISA Kits)-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc (zeige SREBF2 ELISA Kits). Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF (zeige BDNF ELISA Kits)-TrkB signaling as a pathologic mechanism during periods of chronic stress.
inhibition of Sig (zeige PICALM ELISA Kits)-1 R prevented cocaine-induced TrkB activation in hippocampal neurons.
After spinal cord injury, astrocyte-specific TrkB knock-out mice showed reduced hyperpathic responses and improved motor coordination.
Results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the brain-derived neurotrophic factor (zeige BDNF ELISA Kits) -ERK1/2 (zeige MAPK1/3 ELISA Kits)-cAMP response element-binding protein (zeige CREB ELISA Kits) pathway through tropomyosin receptor kinase (zeige NTRK1 ELISA Kits) B activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.
Data show that c-Jun NH2-terminal kinase (JNK (zeige MAPK8 ELISA Kits))-interacting protein-3 (JIP3 (zeige MAPK8IP3 ELISA Kits)) participates in the migration of cortical neurons during cortical development by mediating TrkB receptor axonal anterograde transport.
findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR (zeige GRIN1 ELISA Kits)-CaMKII (zeige CAMK2G ELISA Kits)-dependent BDNF (zeige BDNF ELISA Kits) release from stimulated dendritic spines and subsequent TrkB activation on these same spines that is crucial for structural and functional plasticity
Following ethanol administration, phosphorylation of TrkB in the striatum was significantly reduced in wild-type mice.
Results suggest that the therapeutic actions of atypical antidepressant drugs involve various neurocircuits, some of which, but not all, appears to involve BDNF (zeige BDNF ELISA Kits)/TrkB and downstream neuroplastic signaling
These observations provided evidence that brain-derived naeurotrophic factor(BDNF (zeige BDNF ELISA Kits)) and its receptor (BDNF (zeige BDNF ELISA Kits) receptor) secreted by bovine sperm was important in regulation of insulin (zeige INS ELISA Kits) and leptin (zeige LEP ELISA Kits).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf (zeige BDNF ELISA Kits)-Trk-B
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
neurotrophin receptor B xTrkB-alpha
, BDNF/NT-3 growth factors receptor
, neurotrophic tyrosine kinase, receptor, type 2
, BDNF/NT-3 growth factors receptor-like
, neurotrophic tyrosine kinase receptor type 2
, trkB tyrosine kinase
, tyrosine kinase receptor
, BDNF-tropomyosine receptor kinase B
, tropomyosin-related kinase B
, tyrosine kinase receptor B
, neural receptor protein-tyrosine kinase (trkB)
, trkB protein