anti-Maus ROR2 Antikörper für Immunoprecipitation

Recommended ROR2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) Antikörper
  • BDB
  • BDB1
  • NTRKR2
  • Ntrkr2
  • mRor2
  • ROR2
  • bdb
  • bdb1
  • Xror2
  • ntrkr2
  • MGC97773
  • LOC100219935
  • ror2
  • xror2
  • receptor tyrosine kinase like orphan receptor 2
  • receptor tyrosine kinase-like orphan receptor 2
  • receptor tyrosine kinase like orphan receptor 2 L homeolog
  • ROR2
  • Ror2
  • ror2
  • ror2.L
Epitop
AA 900-950
24
20
19
18
8
7
6
5
4
3
3
2
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
153
24
12
4
4
3
2
1
1
1
1
Wirt
Kaninchen
98
55
1
Klonalität
Polyklonal
Konjugat
Dieser ROR2 Antikörper ist unkonjugiert
10
9
8
7
7
5
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
125
63
50
50
11
9
3
2
2
1
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Produktnummer ABIN2747364
$ 485.57
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN222255 IP ELISA WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal
1 ABIN2751315 ELISA IHC IP WB FITC Rabbit IgG AA 900-950 Anmelden zum Anzeigen Polyclonal
1 ABIN5558394 ELISA IHC IP WB Biotin Rabbit Anmelden zum Anzeigen Polyclonal

General

Antigen Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) Antikörper
Epitop AA 900-950
(24), (20), (19), (18), (8), (7), (6), (5), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(153), (24), (12), (4), (4), (3), (2), (1), (1), (1), (1)
Wirt Kaninchen
(98), (55), (1)
Klonalität
Polyklonal
Konjugat Dieser ROR2 Antikörper ist unkonjugiert
(10), (9), (8), (7), (7), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(125), (63), (50), (50), (11), (9), (3), (2), (2), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-ROR2 Antikörper

Target Details ROR2 Anwendungsinformationen Handhabung Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN2751316.
Spezifität The antibody labels a strong band of ROR2 at 113 kDa in ABIN1741697 samples and in other cancer cell lines.
Kreuzreaktivität Maus, Ratte (Rattus)
Kreuzreaktivität (Details) Does not cross react to any other cellular protein.
Produktmerkmale ROR2- selective antibodies were generated against a peptide taken the C-terminal region. The ROR2-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The anti- ROR1-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. The supplier provides ROR2 Western blot positive control samples in ready-to-use SDS-PAGE sample buffer. Limited quantities of antigenic blocking peptide for ROR2 antibody is also available, please inquire before ordering.
Reinigung Affinity Purified
Immunogen Synthetic peptide taken within amino acid region 900-950 on human ROR2 protein.
Isotyp IgG

Target Details ROR2

Produktdetails anti-ROR2 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung ROR2 (ROR2 Antibody Abstract)
Hintergrund The Receptor tyrosine kinase-like Orphan Receptor (ROR) proteins are conserved tyrosine kinase receptors that pattern tissues and organs during embryonic development and in adulthood. ROR family proteins are ligand-dependent transcription factors that are required for skeletal and neuronal development, and modulate cell migration, cell polarity, and convergent extension. RORs act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated by the adapter protein disheveled and the non-receptor tyrosine kinase Src. RORs can either activate or repress Wnt target expression depending on the cellular context and can also modulate signal transduction by sequestering Wnt ligands away from their signaling receptors.The mammalian ROR family of receptor tyrosine kinases consists of two structurally related proteins, ROR1 and ROR2. ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass trans membrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 also interacts with canonical Wnt1 and Wnt3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactylic type B1, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails or the autosomal recessive skeletal disorder, Robinow syndrome which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. ROR2 possesses dual roles in tumorigenesis as a tumor suppressor or activator depending on tumor type. ROR2 expression in primary human Renal Cell Carcinoma (RCC) tumors showed a significant correlation with several Wnt signaling genes, including the classical feedback target gene Axin2.
NCBI Accession NP_004551
UniProt Q01974
Forschungsgebiet Stem Cells, Extracellular Matrix, Tyrosine Kinases
Pathways RTK Signalweg, WNT Signalweg

Anwendungsinformationen

Produktdetails anti-ROR2 Antikörper Target Details ROR2 Handhabung Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Kommentare

Synonyms: neurotrophic tyrosine kinase receptor-related 2/ NTRKR2

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-ROR2 Antikörper Target Details ROR2 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 0.55-0.75 μg/μL
Handhabung Working solutions of antibodies in buffer should be filtered through 0.45 μm filter after every use for long-term storage.
Lagerung -20 °C
Informationen zur Lagerung For long-term storage of keep at -20 °C. We don't recommend storage of very dilute antibody solutions unless they are prepared in specially formulated multi use antibody dilution buffer.