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Dysregulation of primary PLC (zeige HSPG2 ELISA Kits) signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review)
The products of PLC (zeige HSPG2 ELISA Kits)-gamma activity mediate the innate immune response by regulating respiratory burst, phagocytosis, cell adhesion, and cell migration. (Review)
1,25(OH)2D3 indirectly modulates the differentiation of Treg/Th17 cells by a ff ;ecting the VDR (zeige CYP27B1 ELISA Kits)/PLC-gamma1/TGF-beta1pathway. These results indicate that administration 1,25(OH)2D3 supplements may be a beneficial treatment for organ transplantation recipients.
These results suggest that immobilized EGF (zeige EGF ELISA Kits) increases collective keratinocyte displacement via an increase in single-cell migration persistence resulting from altered EGFR (zeige EGFR ELISA Kits) trafficking and PLCgamma1 activation.
High PLC (zeige HSPG2 ELISA Kits) gamma expression is associated with breast cancer.
We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (zeige AKT1 ELISA Kits). As well as defining a novel mechanism of Akt (zeige AKT1 ELISA Kits) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (zeige FGFR2 ELISA Kits), Plc11 and Grb2 (zeige GRB2 ELISA Kits) correlate with patient survival
These results indicate that PP1 (zeige PPA1 ELISA Kits) is recruited to the extracellular calcium-dependent E-cadherin (zeige CDH1 ELISA Kits)-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC (zeige HSPG2 ELISA Kits)-g1 activation leading to keratinocyte differentiation.
FGFR1 (zeige FGFR1 ELISA Kits) dimers forms a complex with its effector PLCgamma1.
High PLC gamma1 expression is associated with gastric adenocarcinoma.
Report PLCG1 genetic alterations in angiosarcomas.
our studies demonstrate that PLCgamma1 is important for pre-TCR mediated signal transduction and pre-T cell development.
Knock-down of PLC-gamma-1 induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 (zeige RUNX1 ELISA Kits) and subsequent PU.1 upregulation while subsequent rescue of RUNX1 (zeige RUNX1 ELISA Kits) in sh-PLC-gamma-1-transfected cells strongly inhibited foreign body giant cell formation.
study shows that PLCgamma1 controls osteoclast numbers via a CSF-1 (zeige CSF1 ELISA Kits)-dependent DAG/beta-catenin (zeige CTNNB1 ELISA Kits)/cyclinD1 pathway.
this study shows that PLC-gamma1 contributes to protective activity of LAT (zeige LAT ELISA Kits) activity in vivo
PLCgamma1 signaling is involved in the formation of neuronal processes for functionally faithful brain development. [review]
FGFR1 (zeige FGFR1 ELISA Kits)/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.
platelet activation through GPVI (zeige GP6 ELISA Kits) and alphaIIbbeta3 utilizes PLCgamma2 (zeige PLCG2 ELISA Kits) because PLCgamma1 levels are insufficient to support responsiveness, but that PLCgamma1 can restore responsiveness if expressed at levels normally achieved by PLCgamma2 (zeige PLCG2 ELISA Kits).
foci are polymerized de novo as a result of the T cell receptor (TCR) proximal tyrosine kinase (zeige TYRO3 ELISA Kits) cascade, and facilitate distal signaling events including PLCgamma1 activation and subsequent cytoplasmic calcium ion elevation
The result indicate that LAT (zeige LAT ELISA Kits)-PLCg1 interaction is important for controlling IL-6 (zeige IL6 ELISA Kits) production by T cells and demonstrate a critical role of IL-6 (zeige IL6 ELISA Kits) in the development of the lymphoproliferative syndrome.
low level of LAT (zeige LAT ELISA Kits)-PLC-gamma1 interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
This study is the first to indicate that PLC gamma 1 is expressed in bovine adrenal chromaffin cells and has the potential to be activated.
Tyrosine775 is identified as a new, functionally important phosphorylation site on PLC gamma 1; phosphorylation of both Y775 and Y783 is required for PLC gamma 1 activation as measured by antigen receptor-induced Ca2 (zeige CA2 ELISA Kits)+ flux, NF-AT (zeige NFATC3 ELISA Kits) and AP-1 (zeige JUN ELISA Kits) activation.
PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src (zeige SRC ELISA Kits) homology (SH2C) domain.
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
, Phospholipase C-beta1
, phosphoinositide phospholipase C
, phosphoinositide phospholipase C-beta-1
, phospholipase C-I
, phospholipase C-beta-1
, PLC gamma 1
, phospholipase C-gamma-1b
, phospholipase C, gamma 1
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
, monophosphatidylinositol phosphodiesterase
, phosphatidylinositol phospholipase C
, phosphoinositidase C
, phosphoinositide phospholipase C-gamma-1
, phospholipase C, gamma 1 (formerly subtype 148)
, phospholipase C-148
, phospholipase C-II
, phospholipase C-gamma-1
, triphosphoinositide phosphodiesterase
, cell differentiation and embryonic development