anti-Human MDK Antikörper für Immunohistochemistry (Frozen Sections)

Recommended MDK Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Midkine (Neurite Growth-Promoting Factor 2) (MDK) Antikörper
  • MK-B
  • PTF-alpha-1
  • mdk
  • midkine
  • negf2
  • MK
  • Mek
  • ARAP
  • NEGF2
  • RIHB
  • midkine (neurite growth-promoting factor 2)
  • midkine
  • mdk-b
  • Mdk
  • MDK
Reaktivität
Human
136
47
40
5
3
2
2
2
2
1
1
Wirt
Kaninchen
130
18
Klonalität
Polyklonal
Konjugat
Dieser MDK Antikörper ist unkonjugiert
19
9
5
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
119
66
30
13
11
10
9
7
6
6
1
1
Hersteller
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Produktnummer ABIN115508
$ 478.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN5662050 ICC IHC (fro) IHC (p) ELISA WB Mouse IgG AA 22-143 Anmelden zum Anzeigen

General

Antigen Midkine (Neurite Growth-Promoting Factor 2) (MDK) Antikörper
Reaktivität Human
(136), (47), (40), (5), (3), (2), (2), (2), (2), (1), (1)
Wirt Kaninchen
(130), (18)
Klonalität
Polyklonal
Konjugat Dieser MDK Antikörper ist unkonjugiert
(19), (9), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(119), (66), (30), (13), (11), (10), (9), (7), (6), (6), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-MDK Antikörper

Target Details MDK Anwendungsinformationen Handhabung Referenzen für anti-MDK Antikörper (ABIN115508) Bilder
Sequenz MKHHHHHHHM KKKDKVKKGG PGSECAEWAW GPCTPSSKDC GVGFREGTCG AQTQRIRCRV PCNWKKEFGA DCKYKFENWG ACDGGTGTKV RQGTLKKARY NAQCQETIRV TKPCTPKTKA KAKAKKGKGK D
Spezifität This antibody reacts to Midkine.
Reinigung Immunoaffinity chromatography
Immunogen Recombinant Human Midkine produced in E.Coli

Target Details MDK

Produktdetails anti-MDK Antikörper Anwendungsinformationen Handhabung Referenzen für anti-MDK Antikörper (ABIN115508) Bilder zurück nach oben
Antigen
Andere Bezeichnung Midkine (MDK Antibody Abstract)
Hintergrund Midkine (MK, also called neurite growth promoting factor 2, NEGF-2), a product of a retinoic acid responsive gene, is a secreted 13 kDa protein belonging to the family of heparin binding growth/differentiation factors. MK shares 45 % sequence identity with other member of this family called Pleiotrophin (HB-GAM). Midkine is composed of two domains held together by disulfide linkages. The C-terminally located domain contains two heparin binding sites and is usually responsible for midkine activity. Part of the MK activity is enhanced by dimerization of MK. Midkine has been found in vertebrates from human to zebrafish and is most strongly expresed in midgestation. In the adult MK expression is restricted. In addition to normal development, MK is also involved in the pathogenesis of diseases e.g. inflammatory diseases, human carcinomas such as esophageal, stomach, colon, pancreatic, thyroid, lung, urinary, hepatocellular, neuroblastoma, glioblastoma, Wilm´s tumor etc. High MK levels are associated with poor prognosis in some type of cancer. The increased expresion in many carcinomas indicates that MK can be applied to the diagnosis of malignancy. Midkine is expressed during the reparative stage of bone fractures, also supresses infection of certain viruses including HIV in target cells. Anti-apoptotic and cell protecting activity of midkine makes it to be a promissing in therapy.Synonyms: Amphiregulin-associated protein, MDK, MK, MK1, Midgestation and kidney protein, NEGF2, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein
Gen-ID 4192
NCBI Accession NP_001012333
UniProt P21741
Forschungsgebiet Neurology
Pathways RTK Signalweg, M Phase, Skeletal Muscle Fiber Development

Anwendungsinformationen

Produktdetails anti-MDK Antikörper Target Details MDK Handhabung Referenzen für anti-MDK Antikörper (ABIN115508) Bilder zurück nach oben
Applikationshinweise ELISA. Western Blot. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-MDK Antikörper Target Details MDK Anwendungsinformationen Referenzen für anti-MDK Antikörper (ABIN115508) Bilder zurück nach oben
Rekonstitution Restore with 0.05 mL of deionized water
Konzentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE
Konservierungsmittel Azide free
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months.
Haltbarkeit 6 months

Referenzen für anti-MDK Antikörper (ABIN115508)

Produktdetails anti-MDK Antikörper Target Details MDK Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Hara, Ikeda, Shimada, Nagamine, Sawa, Oda: "[Surgical experience of 6 multiple primary lung cancers]" in: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 61, Issue 3, pp. 183-7, 2008

Allgemeine Veröffentlichungen

Dai, Xu, Yao, Min, Zhao, Xu, Xu, Lu: "Construction of a fusion protein expression vector MK-EGFP and its subcellular localization in different carcinoma cell lines." in: World journal of gastroenterology : WJG, Vol. 12, Issue 47, pp. 7649-53, 2006