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Human ERBB3 Protein expressed in Human Cells - ABIN3216381
Alimandi, Romano, Curia, Muraro, Fedi, Aaronson, Di Fiore, Kraus: Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. in Oncogene 1995
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Mouse (Murine) ERBB3 Protein expressed in Human Cells - ABIN2008508
Wallasch, Weiss, Niederfellner, Jallal, Issing, Ullrich: Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. in The EMBO journal 1995
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Results shows that HER3 mRNA is upregulated in hepatocellular carcinoma associated to chronic HBV infection.
Controlled activation of specific EGFR (zeige EGFR Proteine), HER2 (zeige ERBB2 Proteine) and HER3 homodimers and heterodimers caused oesophageal squamous epithelial cell migration and/or invasion.
Results suggest that APIP (zeige APIP Proteine) stimulates cell proliferation via ERBB3, acting in conjunction with ERBB2 (zeige ERBB2 Proteine), in gastric cancer cells.
Data show that afatinib resistant clones were selectively killed by knock down of ERBB3 + c-MET + c-KIT, but not by the individual or doublet knock down combinations, and the combination of afatinib with the SRC (zeige SRC Proteine) family inhibitor dasatinib killed afatinib resistant H1975 cells in a greater than additive fashion.
results suggest that the combination of a histone deacetylase (zeige HDAC1 Proteine) inhibitor (HDACi) plus an anti-ErbB3 MoAb represents a viable strategy that warrants further evaluation for the treatment of non-small cell lung cancer (NSCLC) patients.
characterized the specific interactome of the epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) family member ERBB2 (zeige ERBB2 Proteine) when in the form of a homodimer or when in the form of a heterodimer with either EGFR (zeige EGFR Proteine) or ERBB3.
observations suggest that Rtn4A counteracts the Nrdp1-mediated degradation of ErbB3 by sequestering the ubiquitin ligase into ER tubules.
Engineered multivalency enhanced affibody-mediated HER3 downregulation in multiple cancer cell types.
Both ERBB2 (zeige ERBB2 Proteine) and ERBB3 are essential for normal proliferation of skin keratinocytes, but in contrast to ERBB3, ERBB2 (zeige ERBB2 Proteine) is essential for migration of human keratinocytes.
Pretreatment with the soluble ErbB3 N418Q mutant suppressed heregulin (zeige NRG1 Proteine) beta1-induced HIF-1alpha (zeige HIF1A Proteine) activation in MCF7 cells.
Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Our results support a role for the hepatocellular ERBB (zeige EGFR Proteine) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (zeige EGFR Proteine)-ERBB3 DKO models, suggesting that EGFR (zeige EGFR Proteine)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (zeige EGFR Proteine) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (zeige SHH Proteine)) stimulate branching morphogenesis (BrM (zeige SMARCA2 Proteine)) and induced synthesis of mRNAs for Ptch1 (zeige PTCH1 Proteine) protein, epidermal growth factor (EGF (zeige EGF Proteine)) and receptors of the ErbB (zeige EGFR Proteine) receptors ErbB1 (zeige EGFR Proteine), ErbB2 (zeige ERBB2 Proteine) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (zeige ERBB4 Proteine) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (zeige AKT1 Proteine) pathway and promoting erbB2 (zeige ERBB2 Proteine)-driven mammary/breast tumorigenesis.
Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (zeige STAT3 Proteine) activation.
ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.
ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.
Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.
Data show that Her8a is a negative regulator of neurogenesis and plays an essential role in generating progenitor pools within rhombomeres 2 and 4--a role resembling that of Her3.
Transcription of her3 is repressed rather than activated by Notch (zeige NOTCH1 Proteine) signalling.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, transcription factor HES-3
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3