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Mouse (Murine) ERBB3 Protein expressed in Human Cells - ABIN2008508
Alimandi, Romano, Curia, Muraro, Fedi, Aaronson, Di Fiore, Kraus: Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. in Oncogene 1995
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Human ERBB3 Protein expressed in Human Cells - ABIN3216381
Wallasch, Weiss, Niederfellner, Jallal, Issing, Ullrich: Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. in The EMBO journal 1995
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Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Both ERBB2 (zeige ERBB2 Proteine) and ERBB3 are essential for normal proliferation of skin keratinocytes, but in contrast to ERBB3, ERBB2 (zeige ERBB2 Proteine) is essential for migration of human keratinocytes.
Pretreatment with the soluble ErbB3 N418Q mutant suppressed heregulin (zeige NRG1 Proteine) beta1-induced HIF-1alpha (zeige HIF1A Proteine) activation in MCF7 cells.
we show that WASF3 (zeige WASF3 Proteine) is present in the HER2 (zeige ERBB2 Proteine) immunocomplex and suppression of WASF3 (zeige WASF3 Proteine) function leads to suppression of invasion even in the presence of HER2 (zeige ERBB2 Proteine) expression.The engagement of WASF3 (zeige WASF3 Proteine) with the HER2 (zeige ERBB2 Proteine)/HER3 complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2 (zeige ERBB2 Proteine)/HER3 activation of JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling.
This study demonstrates novel regulatory circuits involving miR (zeige MLXIP Proteine)-148a-3p/ERBB3/AKT2 (zeige AKT2 Proteine)/c-myc (zeige MYC Proteine) and DNMT1 (zeige DNMT1 Proteine) that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.
HRG (zeige NRG1 Proteine)/HER2 (zeige ERBB2 Proteine)/HER3 signaling promotes AhR (zeige AHR Proteine)-mediated Memo-1 (zeige MEMO1 Proteine) expression and migration in colorectal cancer
Simultaneous suppression of ErbB (zeige EGFR Proteine) kinases and androgen signaling by Celecoxib represents a novel strategy to interrupt the vicious cycle of AR/ErbB (zeige EGFR Proteine) cross-talk with the primary purpose of undermining their resilient signaling in prostate cancer progression.
Targeting both HER2 (zeige ERBB2 Proteine) and HER3 resulted in an improved treatment effects on HER2 (zeige ERBB2 Proteine)-positive gastric cancer.
HER3 is frequently overexpressed in high-grade dysplastic lesions of the gastroesophageal junction and may be a marker of invasive progression
the mechanistic regulation and linkage of the ROR1 (zeige ROR1 Proteine)-HER3 and Hippo-YAP (zeige YAP1 Proteine) pathway in a cancer-specific context
There were significant differences in human epidermal growth factor receptor (zeige EGFR Proteine) 2 and human epidermal growth factor receptor (zeige EGFR Proteine) 3 serum levels between the patients with tissue human epidermal growth factor receptor (zeige EGFR Proteine) 2-positive and tissue human epidermal growth factor receptor (zeige EGFR Proteine) 2-negative ( p = 0.0026, p = 0.000011) tumors, but not in the serum levels of human epidermal growth factor receptor (zeige EGFR Proteine) 4 ( p = 0.054).
Our results support a role for the hepatocellular ERBB (zeige EGFR Proteine) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (zeige EGFR Proteine)-ERBB3 DKO models, suggesting that EGFR (zeige EGFR Proteine)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (zeige EGFR Proteine) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (zeige SHH Proteine)) stimulate branching morphogenesis (BrM (zeige SMARCA2 Proteine)) and induced synthesis of mRNAs for Ptch1 (zeige PTCH1 Proteine) protein, epidermal growth factor (EGF (zeige EGF Proteine)) and receptors of the ErbB (zeige EGFR Proteine) receptors ErbB1 (zeige EGFR Proteine), ErbB2 (zeige ERBB2 Proteine) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (zeige ERBB4 Proteine) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (zeige AKT1 Proteine) pathway and promoting erbB2 (zeige ERBB2 Proteine)-driven mammary/breast tumorigenesis.
Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (zeige STAT3 Proteine) activation.
ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.
ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.
Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase