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Colitis significantly downregulates Ephb6 expression in the neurons of the spinal dorsal horn.
T-cell development in EphB6 knockout mice
EphB6 is pivotal in T cell function as shown by its null mutation
Enhanced EphB6 expression was significantly associated with Thyroid Lesions.
EphB6 protein may be used as a new marker for prognosis for tongue squamous cell carcinoma.
EphB6 is a new biomarker for distinguishing high- and low-grade ovarian serous carcinoma, and may be a potential prognostic marker in ovarian serous carcinomas.
EphB6 also interacts with the Hsp90 chaperone (zeige HSP90 ELISA Kits).
These findings implicate EphB6 as a negative regulator of EphA2 (zeige EPHA2 ELISA Kits) oncogenic signaling.
We demonstrate that EphB6 reexpression forces metastatic melanoma cells to deviate from the canonical migration pattern observed in the chick embryo transplant model
Results suggest that erythropoietin (zeige EPO ELISA Kits)-producing hepatocyte (Eph) receptor B6 (EphB6) may represent a useful tissue biomarker for the prediction of survival rate in colorectal cancers (CRCs).
Studies clearly demonstrate an inverse relationship between the levels of phospho-ERK (zeige EPHB2 ELISA Kits) and the abundance of cadherin 17, beta-catenin (zeige CTNNB1 ELISA Kits) and phospho-GSK3beta (zeige GSK3b ELISA Kits) in EPHB6-expressing MDA-MB-231 cells.
Data found significant correlations between ephA2 (zeige EPHA2 ELISA Kits), ephA4 (zeige EPHA4 ELISA Kits), ephA7 (zeige EPHA7 ELISA Kits), ephB4 (zeige EPHB4 ELISA Kits), and ephB6 and overall and/or recurrence-free survival in large microarray datasets.
Our work shows that EphB3 (zeige EPHB3 ELISA Kits) is consistently expressed by malignant T lymphocytes, most frequently in combination with EphB6, and that stimulation with their common ligands strongly suppresses Fas (zeige FAS ELISA Kits)-induced apoptosis in these cells.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.
Chicken embryo kinase 9
, EPH-like kinase 9
, ephrin type-B receptor 5
, ephrin receptor EphB6
, ephrin type-B receptor 6
, EPH receptor B6
, ephrin type-B receptor 6-like
, chicken eph/elk receptor-like protein
, ephrin type A receptor
, tyrosine-protein kinase-defective receptor EPH-6
, human kinase-defective Eph-family receptor protein