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Loss of microRNA-dependent regulation of Arpc5, which controls the distribution of germ cell mRNAs between translationally active and inactive pools, results in abnormal round spermatid differentiation and impaired fertility.
GRAIL (zeige RNF128 Proteine) functions via the ubiquitination and degradation of actin cytoskeleton-associated proteins, in particular Arp2 (zeige AICDA Proteine)/3-5 and coronin 1A (zeige CORO1A Proteine)
Levels of ARPC5 expression were significantly higher in invasive cancer cells and gene expression was directly regulated by miR (zeige MLXIP Proteine)-133a.
identified as a substrate of MAPK-activated protein kinase 2(MAPKAPK2 (zeige MAPKAPK2 Proteine)); the ability of MAPKAPK2 (zeige MAPKAPK2 Proteine) to phosphorylate one isoform of p16-Arc suggests a possible mechanism by which the p38 MAPK (zeige MAPK14 Proteine) cascade regulates remodeling of the actin cytoskeleton
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene.
actin-related protein 2/3 complex subunit 5
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
, actin related protein 2/3 complex subunit 5
, actin related protein 2/3 complex, subunit 5, 16kDa
, arp2/3 complex 16 kDa subunit
, Arp2/3 protein complex subunit p16