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Mechanistically, BRAF (zeige BRAF Proteine) and RAF1 (zeige RAF1 Proteine) operate independently to balance MAPK (zeige MAPK1 Proteine) signaling: BRAF (zeige BRAF Proteine) promotes ERK (zeige EPHB2 Proteine) activation, while RAF1 (zeige RAF1 Proteine) dims stress kinase activation.
Mass spectrometry based screening for potential interaction partners revealed that BRAF (zeige BRAF Proteine) interacts and phosphorylates PAX3 (zeige PAX3 Proteine).
Using a conditional allele for Braf (zeige BRAF Proteine)(V600E) , a mutation observed in clinical cases of GIST, authors observed that Braf (zeige BRAF Proteine)(V600E) activation was sufficient to drive ICC hyperplasia but not GIST tumorigenesis.
This study detected the BrafV637E mutation by whole-exome analysis in 4/4 hepatic tumors induced by neonatal treatment with diethylnitrosamine (DEN) in male B6C3F1 mice.
a critical threshold for inhibition of MAPK (zeige MAPK1 Proteine) signaling is required to optimally restore expression of thyroid differentiation genes in thyroid cells and in mice with BrafV600E-induced thyroid cancer.
A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability.
these contrasting signatures precisely match those proposed to confer bias toward Hras (zeige HRAS Proteine)(CAA61CTA) versus Braf (zeige BRAF Proteine)(GTG636GAG) mutations in the original tumor sets. Our findings highlight a novel mechanism whereby exposure history acts through strand-biased mutagenesis to specify activation of preferred oncogenes
these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf-dependent p38 MAPK (zeige MAPK14 Proteine) signaling cascade.
BRAF (zeige BRAF Proteine) V600E inhibition stimulates AMP-activated protein kinase (zeige PRKAA2 Proteine)-mediated autophagy in colorectal cancer cells.
these data confirm the existence of a negative feedback pathway by which BRAF (zeige BRAF Proteine) protein stability is regulated by ERK (zeige EPHB2 Proteine).
Overexpression of SNRPE is associated with highly aggressive breast cancers.
Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex
In the SME intron, the position of the branchpoint A residue within the region base paired with U12 differs from that in P120 (zeige HNRNPU Proteine) and XTF.
growth arrest by SmE directly correlates with the reduction of cyclin E (zeige CCNE1 Proteine), CDK2 (zeige CDK2 Proteine), CDC25C (zeige CDC25C Proteine) and CDC2 (zeige CDK1 Proteine) expression, and up-regulation of p27Kip
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5 (By similarity).
sm protein E
, small nuclear ribonucleoprotein E
, small nuclear ribonucleoprotein polypeptide E
, SmE protein