Protein Associated with Topoisomerase II Homolog 1 (Yeast) Proteine (PATL1)

Bezeichnung:
Protein Associated with Topoisomerase II Homolog 1 (Yeast) Proteine (PATL1)
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Synonyme:
AV312086, D430024J04, fa11d04, hPat1b, Pat1b, RGD1305514, wu:fa11d04, xPat1b, zgc:158239
alle Proteine anzeigen Gen GeneID UniProt
PATL1 219988 Q86TB9
PATL1 225929 Q3TC46
PATL1 361736 B5DF93

Weitere Synonyme anzeigen

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Human Protein Associated with Topoisomerase II Homolog 1 (Yeast) (PATL1) Interaktionspartner

  1. data indicate that P-body assembly occurs in a step-wise manner, where Rck (zeige DDX6 Proteine) participates in the initial suppression of mRNA translation, whereas Pat1b in a second step triggers P-body assembly and promotes mRNA decapping

  2. The PATL1 as well as DCP1A (zeige DCP1A Proteine), a well-known P-body marker, co-localized with a subset of ALG-2 (zeige PDCD6 Proteine).

  3. Pat1b participates in several RNA-related nuclear processes in addition to its multiple regulatory roles in the cytoplasm

  4. Pat1b represses gene expression by inducing deadenylation of the mRNAs.

  5. hPat1b localizes to P-bodies, while mPat1a-GFP is either found weakly in P-bodies or disperses P-bodies in a dominant-negative fashion.

  6. By tethering Pat1b to a reporter mRNA, the study provides evidence that Pat1b is also functionally linked to both deadenylation and decapping.

  7. Data show that PatL1 is essential for the interaction with mRNA decapping factors (i.e. DCP2 (zeige DCP2 Proteine), EDC4 (zeige EDC4 Proteine) and LSm1 (zeige LSM1 Proteine)-7), whereas the P-rich region and Mid domain have distinct functions in modulating these interactions.

  8. The identification of two human PAT1 genes is described and one of them, PATL1, codes for an open reading frame with similar features as the yeast PAT1.

Protein Associated with Topoisomerase II Homolog 1 (Yeast) (PATL1) Protein Überblick

Protein Überblick

RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly (By similarity).

Alternative names and synonyms associated with Protein Associated with Topoisomerase II Homolog 1 (Yeast) (PATL1)

  • protein associated with topoisomerase II homolog 1 (yeast) (PATL1)
  • protein associated with topoisomerase II homolog 1 (patl1)
  • protein associated with topoisomerase II homolog 1 (yeast) (Patl1)
  • protein associated with topoisomerase II homolog 1 (yeast) (patl1)
  • AV312086 Protein
  • D430024J04 Protein
  • fa11d04 Protein
  • hPat1b Protein
  • Pat1b Protein
  • RGD1305514 Protein
  • wu:fa11d04 Protein
  • xPat1b Protein
  • zgc:158239 Protein

Bezeichner auf Proteinebene für PATL1

protein associated with topoisomerase II homolog 1 (yeast) , protein PAT1 homolog 1 , PAT1-like protein 1 , Protein PAT1 homolog 1 , Protein PAT1 homolog b , protein PAT1 homolog b

GENE ID SPEZIES
466618 Pan troglodytes
537453 Bos taurus
609696 Canis lupus familiaris
699207 Macaca mulatta
100355434 Oryctolagus cuniculus
100407719 Callithrix jacchus
100483301 Ailuropoda melanoleuca
100581759 Nomascus leucogenys
443620 Xenopus laevis
219988 Homo sapiens
225929 Mus musculus
361736 Rattus norvegicus
100173027 Pongo abelii
100009659 Danio rerio
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