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data indicate that P-body assembly occurs in a step-wise manner, where Rck (zeige DDX6 Proteine) participates in the initial suppression of mRNA translation, whereas Pat1b in a second step triggers P-body assembly and promotes mRNA decapping
The PATL1 as well as DCP1A (zeige DCP1A Proteine), a well-known P-body marker, co-localized with a subset of ALG-2 (zeige PDCD6 Proteine).
Pat1b participates in several RNA-related nuclear processes in addition to its multiple regulatory roles in the cytoplasm
Pat1b represses gene expression by inducing deadenylation of the mRNAs.
hPat1b localizes to P-bodies, while mPat1a-GFP is either found weakly in P-bodies or disperses P-bodies in a dominant-negative fashion.
By tethering Pat1b to a reporter mRNA, the study provides evidence that Pat1b is also functionally linked to both deadenylation and decapping.
Data show that PatL1 is essential for the interaction with mRNA decapping factors (i.e. DCP2 (zeige DCP2 Proteine), EDC4 (zeige EDC4 Proteine) and LSm1 (zeige LSM1 Proteine)-7), whereas the P-rich region and Mid domain have distinct functions in modulating these interactions.
The identification of two human PAT1 genes is described and one of them, PATL1, codes for an open reading frame with similar features as the yeast PAT1.
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly (By similarity).
protein associated with topoisomerase II homolog 1 (yeast)
, protein PAT1 homolog 1
, PAT1-like protein 1
, Protein PAT1 homolog 1
, Protein PAT1 homolog b
, protein PAT1 homolog b