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Human Monoclonal PRDM1 Primary Antibody für ChIP, ELISA - ABIN153174
John, Clements, Russell, Garrett-Sinha: Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1. in The Journal of biological chemistry 2008
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Human Monoclonal PRDM1 Primary Antibody für ELISA, ICC - ABIN314189
Liu, Leboeuf, Shi, Li, Wang, Shen, Garcia, Shen, Chen, Janin, Chen, Zhao: Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma. in Blood 2007
Show all 11 Pubmed References
Human Monoclonal PRDM1 Primary Antibody für ELISA, IHC (fro) - ABIN314190
Ohinata, Payer, OCarroll, Ancelin, Ono, Sano, Barton, Obukhanych, Nussenzweig, Tarakhovsky, Saitou, Surani: Blimp1 is a critical determinant of the germ cell lineage in mice. in Nature 2005
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Human Monoclonal PRDM1 Primary Antibody für ICS, IHC (p) - ABIN2688853
Chan, Chiang, Tsai, Su, Chen, Hou, Lin: Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in dendritic cell homeostatic development and function. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Human Monoclonal PRDM1 Primary Antibody für IHC, WB - ABIN2668849
Valer Corellano: [Malignant fibrous histiocytoma of soft tissues: early report of 10 cases]. in Medicina clínica 1991
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Human Monoclonal PRDM1 Primary Antibody für ELISA, WB - ABIN1724737
Ancelin, Lange, Hajkova, Schneider, Bannister, Kouzarides, Surani: Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. in Nature cell biology 2006
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Human Polyclonal PRDM1 Primary Antibody für FM, ELISA - ABIN1001904
Angelin-Duclos, Cattoretti, Lin, Calame: Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. in Journal of immunology (Baltimore, Md. : 1950) 2000
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Human Polyclonal PRDM1 Primary Antibody für IHC, ELISA - ABIN1001905
Martins, Cimmino, Shapiro-Shelef, Szabolcs, Herron, Magnusdottir, Calame: Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. in Nature immunology 2006
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Human Polyclonal PRDM1 Primary Antibody für - ABIN2017609
Oestreich, Mohn, Weinmann: Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. in Nature immunology 2012
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Human Monoclonal PRDM1 Primary Antibody für FACS - ABIN4256285
Joo, Li, Dullaers, Kim, Duluc, Upchurch, Xue, Zurawski, Le Grand, Liu, Kuroda, Zurawski, Oh: C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses. in Immunity 2014
BLIMP1 (PRDM1)expression begins throughout the hypoblast at stage 1 and emerges in single primordial germ cell (PGC (zeige PGC Antikörper)) precursors in the posterior epiblast at stage 2.
The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
Blimp-1 gene is transcribed during prepupal development when the ecdysteroid titer is high, but the expressed mRNA degrades rapidly.
Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.
Expression of the M- and N-cadherins, previously implicated in driving adaxial cell migration, is largely unaffected by loss of Prdm1a function, suggesting that differential cadherin expression is not sufficient for adaxial cell migration
Prdm1a functions as both a transcriptional activator and repressor during neural crest development.
identify sox6 cis (zeige CISH Antikörper)-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner
prdm1a expression is upregulated in the absence of Notch (zeige NOTCH1 Antikörper) function, and inhibiting Notch (zeige NOTCH1 Antikörper) signaling fails to rescue prdm1a mutants
prdm1a Regulates sox10 (zeige SOX10 Antikörper) and islet1 (zeige ISL1 Antikörper) in the development of neural crest and Rohon-Beard sensory neurons.
These results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton.
Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers, encodes the zebrafish homolog of Blimp-1
The transcriptional regulator Blimp-1 plays a role in the inception of Neural Crest progenitor fate through BMP signalling.
prdm1/blimp1 has roles in embryo patterning and organogenesis
prdm1 functions to promote the cell fate specification of both neural crest cells and sensory neurons
HSP70 (zeige HSP70 Antikörper)-Hrd1 (zeige SYVN1 Antikörper) axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants.
SOX2 (zeige SOX2 Antikörper) repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase (zeige MBD2 Antikörper) UTX (zeige KDM6A Antikörper) to the SOX2 (zeige SOX2 Antikörper) promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 (zeige SOX17 Antikörper) has been shown to initiate human PGC (zeige PGC Antikörper) specification, with its target PRDM1 suppressing mesendodermal genes
The interaction between c-Maf (zeige MAF Antikörper) and RORgammat, and Blimp-1.
these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC (zeige ABCB6 Antikörper)-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC (zeige ABCB6 Antikörper)-DLBCL patients.
PRDM1 was identified as a susceptibility gene for systemic sclerosis.
Data indicate that BTG2 (zeige BTG2 Antikörper), MAP3K11 (zeige MAP3K11 Antikörper), RPS6KA1 (zeige RPS6KA1 Antikörper) and PRDM1 as putative targets of microRNA miR (zeige MLXIP Antikörper)-125b.
we identified MIR155HG and TERC to be transcriptionally downregulated by PRDM1 in two PRDM1-null NK-cell lines when it is ectopically expressed. These findings suggest that ZFAS1 and other dysregulated long non-coding RNAs may be involved in natural killer/T-cell lymphoma pathobiology through regulation of cancer-related genes, and loss-of-PRDM1 expression in natural killer/T-cell lymphomas tumorigenesis
identified the Prdm1 gene encoding the B lymphocyte-induced maturation protein 1 as a crucial negative regulator of human TH17 cell differentiation
B cell receptor signaling component, SYK (zeige SYK Antikörper), caused PAX5 (zeige PAX5 Antikörper) tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 promoter by PAX5 (zeige PAX5 Antikörper) was attenuated by this phosphorylation.
Depletion of PRDM1 in lung cancer cells promotes cellular invasion and anoikis resistance in vitro and lung metastasis in vivo.
Blimp1 deficiency resulted in reduced suppressive ability of Tfr (zeige TFRC Antikörper) cells. This study identifies that Tfr (zeige TFRC Antikörper) cells are potent suppressors of immunity and are controlled by Blimp1.
Data show that TLR4 (zeige TLR4 Antikörper)-mediated up-regulation of Blimp-1 led to the down-regulation of NLRP12 (zeige NLRP12 Antikörper) expression in dextran sulfate sodium (DSS (zeige PMP22 Antikörper))-induced colitis.
Results established a molecular mechanism of TNF-a (zeige TNF Antikörper)-induced osteoclasts differentiation, and provided insights into the potential contribution of Blimp1 in the regulation of osteoclastogenesis by TNF-a (zeige TNF Antikörper).
results show that the intersection of three or more transcription factors is required to correctly regulate the spatial and temporal features of Blimp1 enhancer expression
findings show that Prdm1 acts independently of Aire (zeige AIRE Antikörper), a crucial transcription factor implicated in medullary thymic epithelial cells function; data highlight a previously unrecognized role for Prdm1 in regulating thymic epithelial function
Prdm1 repressed expression of the gene encoding cathepsin S (Ctss (zeige CTSS Antikörper)). Prdm1 deficiency in dendritic cells led to loss of appropriate regulation of Ctss (zeige CTSS Antikörper) expression in female mice and thereby modulated antigen presentation and the follicular helper T cell repertoire to contribute to autoimmunity in lupus.
Blimp1 is required to maintain a highly proliferative luminal subset necessary for mammary gland development and homeostasis.
Attenuated leptin-receptor (LEPR (zeige LEPR Antikörper)) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR (zeige LEPR Antikörper) and its downstream signaling through the protein PR/SET domain 1 (PRDM1).
role of Blimp-1 as a critical regulator of CD4 (zeige CD4 Antikörper) dysfunction and links it to the CD8 (zeige CD8A Antikörper) T cell dysfunctionality observed in infected mice.
Contextual ablation of BLIMP-1 and p53 (zeige TP53 Antikörper) led to development of IgM (zeige CD40LG Antikörper)-positive B-cell lymphoma with an aggressive phenotype, supported by c-Myc (zeige MYC Antikörper) up-regulation, and accumulation of somatic mutations, as demonstrated by whole exome sequencing.
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
PR domain containing 1, with ZNF domain
, Blimp-1 protein
, B lymphocyte-induced maturation protein 1
, PR domain zinc finger protein 1
, PR domain-containing 1
, U boot
, B lymphocyte induced maturation protein 1
, PR domain zinc finger protein 1-like
, B-lymphocyte-induced maturation protein 1
, PRDI-binding factor-1
, beta-interferon gene positive-regulatory domain I binding factor
, B lymphocyte induced maturation protein
, PR domain containing 1 with ZNF domain
, PR domain-containing protein 1
, beta-interferon gene positive regulatory domain I-binding factor