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Chop was found to exacerbate allergic airway inflammation by enhancing M2 programming in macrophages
Our findings support that CHOP may be an important signaling molecule in the progression of chronic kidney disease
GPR4 (zeige GPR4 ELISA Kits) blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.
CHOP deficiency prevents HFD-induced insulin (zeige INS ELISA Kits) resistance.
Endoplasmic reticulum stress-induced CHOP activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin (zeige LEP ELISA Kits) and IGF1 (zeige IGF1 ELISA Kits).
a significant protein-protein interaction between GR and CHOP, (GR-CHOP heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
The study shows that FXR (zeige NR1H4 ELISA Kits)/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
Ddit3 suppresses the differentiation of ATDC5 cells
Free CNPY2 (zeige CNPY2 ELISA Kits) then engages protein kinase (zeige CDK7 ELISA Kits) R-like endoplasmic reticulum kinase (PERK (zeige EIF2AK3 ELISA Kits)) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response.
SHP (zeige LAMC1 ELISA Kits) and REV-ERBalpha (zeige NR1D1 ELISA Kits) play a critical role in controlling rhythmic CHOP expression in alcoholic fatty liver
asthmatic patients exhibited aberrant Chop expression along with endoplasmic reticulum stress
CHOP negatively regulates Polo-like kinase 2 (zeige PLK2 ELISA Kits) expression via recruiting C/EBPalpha (zeige CEBPA ELISA Kits) to the upstream-promoter in human osteosarcoma cell line during ER stress
VEGF is an important angiogenic signal required for tissue expansion. We show that VEGFA variation giving allele-specific response to transcription factors with overlapping binding sites associate closely with circulating TSH levels. Because CHOP is induced by several types of intracellular stress, this indicates that cellular stress could be involved in the normal or pathophysiological response of the thyroid to TSH
GRP78 (zeige HSPA5 ELISA Kits) inhibition enhances ATF4 (zeige ATF4 ELISA Kits)-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma cells.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK (zeige MAPK8 ELISA Kits), AP-1 (zeige FOSB ELISA Kits), and CHOP may interfere with complete autophagy.
The role of neutrophil elastase (zeige ELANE ELISA Kits) in the activation of unfolded protein response effector molecules via PERK (zeige EIF2AK3 ELISA Kits) and CHOP is reported.
The PERK (zeige EIF2AK3 ELISA Kits)-eIF2alpha (zeige EIF2A ELISA Kits)-ATF4 (zeige ATF4 ELISA Kits)-CHOP signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
CHOP (GADD153) is an inhibitor of Wnt (zeige WNT2 ELISA Kits)/TCF (zeige HNF4A ELISA Kits) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3